The basic characteristics of extracellular vesicles and their potential application in bone sarcomas

Bone sarcomas are rare cancers accompanied by metastatic disease, mainly including osteosarcoma, Ewing sarcoma and chondrosarcoma. Extracellular vesicles (EVs) are membrane vesicles released by cells in the extracellular matrix, which carry important signal molecules, can stably and widely present i...

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Published inJournal of nanobiotechnology Vol. 19; no. 1; pp. 277 - 12
Main Author Li, Shenglong
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 17.09.2021
BioMed Central
BMC
Subjects
Angiogenesis
Apoptosis
Biological activity
Biomarkers
Biomarkers - metabolism
Biomedical materials
Biosynthesis
Body fluids
Bone cancer
Bone Neoplasms - diagnosis
Bone Neoplasms - pathology
Bone sarcomas
Bone tumors
Breast milk
Cancer diagnosis
Cancer therapy
Care and treatment
Cell interaction
Cell interactions
Cell organelles
Chemotherapy
Chondrosarcoma
Collagen Type VI - metabolism
Communication
Deoxyribonucleic acid
Development and progression
Diagnosis
DNA
Endothelial cells
Ewing's sarcoma
Ewings sarcoma
Extracellular matrix
Extracellular vesicles
Extracellular Vesicles - genetics
Extracellular Vesicles - metabolism
Fibroblasts
Flow cytometry
Health aspects
Heat shock proteins
Humans
Immune system
Invasion and metastasis
Lipids
Medical prognosis
Membrane vesicles
Mesenchyme
Metabolites
Metastases
Metastasis
Microenvironments
MicroRNAs - metabolism
Microscopy
miRNA
mRNA
Osteoclasts
Osteosarcoma
Osteosarcoma - diagnosis
Osteosarcoma - pathology
Physiological aspects
Physiology
Prognosis
Review
Ribonucleic acid
RNA
Saliva
Sarcoma
Scalp
Spinal cord
Stem cells
Teenagers
Tumor Microenvironment
Tumors
Vesicles
China
Extracellular vesicles
Cancer diagnosis
Bone sarcomas
Cancer therapy
Invasion and metastasis
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Abstract Bone sarcomas are rare cancers accompanied by metastatic disease, mainly including osteosarcoma, Ewing sarcoma and chondrosarcoma. Extracellular vesicles (EVs) are membrane vesicles released by cells in the extracellular matrix, which carry important signal molecules, can stably and widely present in various body fluids, such as plasma, saliva and scalp fluid, spinal cord, breast milk, and urine liquid. EVs can transport almost all types of biologically active molecules (DNA, mRNA, microRNA (miRNA), proteins, metabolites, and even pharmacological compounds). In this review, we summarized the basic biological characteristics of EVs and focused on their application in bone sarcomas. EVs can be use as biomarker vehicles for diagnosis and prognosis in bone sarcomas. The role of EVs in bone sarcoma has been analyzed point-by-point. In the microenvironment of bone sarcoma, bone sarcoma cells, mesenchymal stem cells, immune cells, fibroblasts, osteoclasts, osteoblasts, and endothelial cells coexist and interact with each other. EVs play an important role in the communication between cells. Based on multiple functions in bone sarcoma, this review provides new ideas for the discovery of new therapeutic targets and new diagnostic analysis.
AbstractList Bone sarcomas are rare cancers accompanied by metastatic disease, mainly including osteosarcoma, Ewing sarcoma and chondrosarcoma. Extracellular vesicles (EVs) are membrane vesicles released by cells in the extracellular matrix, which carry important signal molecules, can stably and widely present in various body fluids, such as plasma, saliva and scalp fluid, spinal cord, breast milk, and urine liquid. EVs can transport almost all types of biologically active molecules (DNA, mRNA, microRNA (miRNA), proteins, metabolites, and even pharmacological compounds). In this review, we summarized the basic biological characteristics of EVs and focused on their application in bone sarcomas. EVs can be use as biomarker vehicles for diagnosis and prognosis in bone sarcomas. The role of EVs in bone sarcoma has been analyzed point-by-point. In the microenvironment of bone sarcoma, bone sarcoma cells, mesenchymal stem cells, immune cells, fibroblasts, osteoclasts, osteoblasts, and endothelial cells coexist and interact with each other. EVs play an important role in the communication between cells. Based on multiple functions in bone sarcoma, this review provides new ideas for the discovery of new therapeutic targets and new diagnostic analysis.
Bone sarcomas are rare cancers accompanied by metastatic disease, mainly including osteosarcoma, Ewing sarcoma and chondrosarcoma. Extracellular vesicles (EVs) are membrane vesicles released by cells in the extracellular matrix, which carry important signal molecules, can stably and widely present in various body fluids, such as plasma, saliva and scalp fluid, spinal cord, breast milk, and urine liquid. EVs can transport almost all types of biologically active molecules (DNA, mRNA, microRNA (miRNA), proteins, metabolites, and even pharmacological compounds). In this review, we summarized the basic biological characteristics of EVs and focused on their application in bone sarcomas. EVs can be use as biomarker vehicles for diagnosis and prognosis in bone sarcomas. The role of EVs in bone sarcoma has been analyzed point-by-point. In the microenvironment of bone sarcoma, bone sarcoma cells, mesenchymal stem cells, immune cells, fibroblasts, osteoclasts, osteoblasts, and endothelial cells coexist and interact with each other. EVs play an important role in the communication between cells. Based on multiple functions in bone sarcoma, this review provides new ideas for the discovery of new therapeutic targets and new diagnostic analysis.Bone sarcomas are rare cancers accompanied by metastatic disease, mainly including osteosarcoma, Ewing sarcoma and chondrosarcoma. Extracellular vesicles (EVs) are membrane vesicles released by cells in the extracellular matrix, which carry important signal molecules, can stably and widely present in various body fluids, such as plasma, saliva and scalp fluid, spinal cord, breast milk, and urine liquid. EVs can transport almost all types of biologically active molecules (DNA, mRNA, microRNA (miRNA), proteins, metabolites, and even pharmacological compounds). In this review, we summarized the basic biological characteristics of EVs and focused on their application in bone sarcomas. EVs can be use as biomarker vehicles for diagnosis and prognosis in bone sarcomas. The role of EVs in bone sarcoma has been analyzed point-by-point. In the microenvironment of bone sarcoma, bone sarcoma cells, mesenchymal stem cells, immune cells, fibroblasts, osteoclasts, osteoblasts, and endothelial cells coexist and interact with each other. EVs play an important role in the communication between cells. Based on multiple functions in bone sarcoma, this review provides new ideas for the discovery of new therapeutic targets and new diagnostic analysis.
Bone sarcomas are rare cancers accompanied by metastatic disease, mainly including osteosarcoma, Ewing sarcoma and chondrosarcoma. Extracellular vesicles (EVs) are membrane vesicles released by cells in the extracellular matrix, which carry important signal molecules, can stably and widely present in various body fluids, such as plasma, saliva and scalp fluid, spinal cord, breast milk, and urine liquid. EVs can transport almost all types of biologically active molecules (DNA, mRNA, microRNA (miRNA), proteins, metabolites, and even pharmacological compounds). In this review, we summarized the basic biological characteristics of EVs and focused on their application in bone sarcomas. EVs can be use as biomarker vehicles for diagnosis and prognosis in bone sarcomas. The role of EVs in bone sarcoma has been analyzed point-by-point. In the microenvironment of bone sarcoma, bone sarcoma cells, mesenchymal stem cells, immune cells, fibroblasts, osteoclasts, osteoblasts, and endothelial cells coexist and interact with each other. EVs play an important role in the communication between cells. Based on multiple functions in bone sarcoma, this review provides new ideas for the discovery of new therapeutic targets and new diagnostic analysis. Keywords: Extracellular vesicles, Bone sarcomas, Cancer diagnosis, Cancer therapy, Invasion and metastasis
Highlights New role of EVs in cell–cell communication in bone sarcoma. New clinical practicality and future application prospects of EVs. EVs can be use as biomarker vehicles for diagnosis and prognosis in bone sarcomas. Bone sarcomas cells derived EVs may influence angiogenesis, osteoclastogenesis, immunomodulation, drug resistance, invasion, and migration processes.
Bone sarcomas are rare cancers accompanied by metastatic disease, mainly including osteosarcoma, Ewing sarcoma and chondrosarcoma. Extracellular vesicles (EVs) are membrane vesicles released by cells in the extracellular matrix, which carry important signal molecules, can stably and widely present in various body fluids, such as plasma, saliva and scalp fluid, spinal cord, breast milk, and urine liquid. EVs can transport almost all types of biologically active molecules (DNA, mRNA, microRNA (miRNA), proteins, metabolites, and even pharmacological compounds). In this review, we summarized the basic biological characteristics of EVs and focused on their application in bone sarcomas. EVs can be use as biomarker vehicles for diagnosis and prognosis in bone sarcomas. The role of EVs in bone sarcoma has been analyzed point-by-point. In the microenvironment of bone sarcoma, bone sarcoma cells, mesenchymal stem cells, immune cells, fibroblasts, osteoclasts, osteoblasts, and endothelial cells coexist and interact with each other. EVs play an important role in the communication between cells. Based on multiple functions in bone sarcoma, this review provides new ideas for the discovery of new therapeutic targets and new diagnostic analysis. New role of EVs in cell–cell communication in bone sarcoma. New clinical practicality and future application prospects of EVs. EVs can be use as biomarker vehicles for diagnosis and prognosis in bone sarcomas. Bone sarcomas cells derived EVs may influence angiogenesis, osteoclastogenesis, immunomodulation, drug resistance, invasion, and migration processes.
ArticleNumber 277
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Author Li, Shenglong
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Issue 1
Keywords Extracellular vesicles
Cancer diagnosis
Bone sarcomas
Cancer therapy
Invasion and metastasis
Language English
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  year: 2020
  ident: 1028_CR79
  publication-title: Onco Targets Ther
  doi: 10.2147/OTT.S282053
– volume: 10
  start-page: e12033
  issue: 1
  year: 2020
  ident: 1028_CR31
  publication-title: J Extracell Vesicles
  doi: 10.1002/jev2.12033
– volume: 10
  start-page: 471
  issue: 7
  year: 2019
  ident: 1028_CR69
  publication-title: Cell Death Dis
  doi: 10.1038/s41419-019-1675-1
– volume: 12
  start-page: 3019
  issue: 10
  year: 2020
  ident: 1028_CR90
  publication-title: Cancers (Basel)
  doi: 10.3390/cancers12103019
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Snippet Bone sarcomas are rare cancers accompanied by metastatic disease, mainly including osteosarcoma, Ewing sarcoma and chondrosarcoma. Extracellular vesicles (EVs)...
Highlights New role of EVs in cell–cell communication in bone sarcoma. New clinical practicality and future application prospects of EVs. EVs can be use as...
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SubjectTerms Angiogenesis
Apoptosis
Biological activity
Biomarkers
Biomarkers - metabolism
Biomedical materials
Biosynthesis
Body fluids
Bone cancer
Bone Neoplasms - diagnosis
Bone Neoplasms - pathology
Bone sarcomas
Bone tumors
Breast milk
Cancer diagnosis
Cancer therapy
Care and treatment
Cell interaction
Cell interactions
Cell organelles
Chemotherapy
Chondrosarcoma
Collagen Type VI - metabolism
Communication
Deoxyribonucleic acid
Development and progression
Diagnosis
DNA
Endothelial cells
Ewing's sarcoma
Ewings sarcoma
Extracellular matrix
Extracellular vesicles
Extracellular Vesicles - genetics
Extracellular Vesicles - metabolism
Fibroblasts
Flow cytometry
Health aspects
Heat shock proteins
Humans
Immune system
Invasion and metastasis
Lipids
Medical prognosis
Membrane vesicles
Mesenchyme
Metabolites
Metastases
Metastasis
Microenvironments
MicroRNAs - metabolism
Microscopy
miRNA
mRNA
Osteoclasts
Osteosarcoma
Osteosarcoma - diagnosis
Osteosarcoma - pathology
Physiological aspects
Physiology
Prognosis
Review
Ribonucleic acid
RNA
Saliva
Sarcoma
Scalp
Spinal cord
Stem cells
Teenagers
Tumor Microenvironment
Tumors
Vesicles
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Title The basic characteristics of extracellular vesicles and their potential application in bone sarcomas
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Volume 19
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