Colonization resistance is dispensable for segregation of oral and gut microbiota

• Published in: BMC medical genomics Vol. 16; no. 1; pp. 31 - 7
• Main Authors: Rashidi, Armin, Koyama, Motoko, Dey, Neelendu, McLean, Jeffrey S., Hill, Geoffrey R.
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 22.02.2023; BioMed Central; BMC
• Subjects: Anti-Bacterial Agents - therapeutic use; Antibiotics; Bacteria; Chemotherapy; Colon; Colon cancer; Colonic Neoplasms; Colonization; Colonization resistance; Colorectal cancer; Dental plaque; Feces; Feces - microbiology; Gastrointestinal Microbiome; Gut microbiota; Health aspects; Humans; Inflammatory Bowel Diseases; Intestinal microflora; Intestine; Intestines; Leukemia; Medical research; Medicine, Experimental; Microbiology; Microbiota; Microbiota (Symbiotic organisms); Microorganisms; Mouth; Oral microbiota; Physiological aspects; Risk factors; Stem cell transplantation; Stem cells; Success; Transplants & implants; United States; Gut microbiota; Colonization resistance; Oral microbiota

The oral and colonic microbiota are distinct in healthy individuals. However, this distinction is diminished in common diseases such as colon cancer and inflammatory bowel disease, suggesting a potential pathogenic role for oral bacteria when ectopically colonized in the gut. A key mechanism for the...