Molecular mechanisms of epithelial–mesenchymal transition

• Published in: Nature reviews. Molecular cell biology Vol. 15; no. 3; pp. 178 - 196
• Main Authors: Lamouille, Samy, Xu, Jian, Derynck, Rik
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.03.2014; Nature Publishing Group
• Subjects: 631/136/2128; 631/337/572/2102; 631/80/86; Biochemistry; Cancer; Cancer Research; Cell Biology; Cell differentiation; Cell Movement; Cellular control mechanisms; Cytoskeleton - physiology; Developmental Biology; Epithelial-Mesenchymal Transition - genetics; Epithelial-Mesenchymal Transition - physiology; Epithelium; Gene expression; Gene Expression Regulation, Developmental; Genotype & phenotype; Growth factors; Humans; Life Sciences; MicroRNAs; Models, Biological; Mutation; Physiological aspects; Physiological research; Proteins; review-article; RNA - genetics; Signal Transduction; Stem Cells; Transcription factors; Transcription Factors - metabolism; Tumors; Wound healing; United States > US; San Francisco California; California

Key Points The epithelial–mesenchymal transition (EMT) process results in the downregulation of epithelial, and activation of mesenchymal, cell characteristics and behaviour. This transdifferentiation process is initially reversible, with mesenchymal–epithelial transition (MET) enabling reversion to...