Three-dimensional culture and clinical drug responses of a highly metastatic human ovarian cancer HO-8910PM cells in nanofibrous microenvironments of three hydrogel biomaterials

• Published in: Journal of nanobiotechnology Vol. 18; no. 1; pp. 90 - 19
• Main Authors: Song, Hong, Cai, Guo-hui, Liang, Jian, Ao, Di-shu, Wang, Huan, Yang, Ze-hong
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 11.06.2020; BioMed Central; BMC
• Subjects: 3D cell culture; Amino acids; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Biocompatible Materials - chemistry; Biological products; Biomaterials; Biomedical materials; Cancer; Cancer metastasis; Cancer therapies; Cell adhesion & migration; Cell culture; Cell Culture Techniques - methods; Cell growth; Cell growth pattern; Cell Line, Tumor; Cell proliferation; Cell Proliferation - drug effects; Chemoresistance; Chemosensitivity; Cisplatin; Collagen; Collagen (type I); Cytology; Drug resistance; Drug screening; E-cadherin; Female; Growth patterns; HO-8910PM cells; Humans; Hydrogel; Hydrogels; Hydrogels - chemistry; Immunohistochemistry; In vivo methods and tests; Integrins; Metastases; Metastasis; Microenvironments; Morphology; Multicellular tumor spheroids; N-Cadherin; Nanofiber; Nanofibers; Nanofibers - chemistry; Ovarian cancer; Ovarian Neoplasms - metabolism; Paclitaxel; Peptides; Protein expression; Scaffolds; Spheroids; Stem cells; Three dimensional models; Tumor Microenvironment - drug effects; Western blotting; United States > US; China; Chemosensitivity; Cell growth pattern; 3D cell culture; Nanofiber; HO-8910PM cells; Hydrogel

Ovarian cancer is a highly aggressive malignant disease in gynecologic cancer. It is an urgent task to develop three-dimensional (3D) cell models in vitro and dissect the cell progression-related drug resistance mechanisms in vivo. In the present study, RADA16-I peptide has the reticulated nanofiber...