Absence of an embryonic stem cell DNA methylation signature in human cancer

• Published in: BMC cancer Vol. 19; no. 1; pp. 711 - 12
• Main Authors: Zhang, Ze, Wiencke, John K., Koestler, Devin C., Salas, Lucas A., Christensen, Brock C., Kelsey, Karl T.
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 19.07.2019; BioMed Central; BMC
• Subjects: Adult; Algorithms; Analysis; Biological markers; Biomarkers; Cancer; Cancer Epigenomics; Cancer genetics; Cancer research; Cell differentiation; Cell Plasticity; Cellular Reprogramming - genetics; CpG Islands; DNA; DNA methylation; DNA Methylation - genetics; Embryonic stem cells; Epigenesis, Genetic; Female; Gene expression; Genetic Heterogeneity; Genetic Loci; Genomes; Genomics; Human embryonic stem cells; Human Embryonic Stem Cells - metabolism; Humans; Linear Models; Male; Methylation; Neoplasms - genetics; Neoplasms - pathology; Neoplastic Stem Cells - metabolism; Pregnancy; Regression analysis; Statistics, Nonparametric; Stem cells; Transcriptome; Tumors; Human embryonic stem cells; Biomarkers; DNA methylation; Cancer Epigenomics; Cell differentiation

Differentiated cells that arise from stem cells in early development contain DNA methylation features that provide a memory trace of their fetal cell origin (FCO). The FCO signature was developed to estimate the proportion of cells in a mixture of cell types that are of fetal origin and are reminisc...