RNA sequencing identifies transcriptional changes in the rabbit larynx in response to low humidity challenge

• Published in: BMC genomics Vol. 21; no. 1; pp. 888 - 13
• Main Authors: Bailey, Taylor W., dos Santos, Andrea Pires, do Nascimento, Naila Cannes, Xie, Shaojun, Thimmapuram, Jyothi, Sivasankar, M. Preeti, Cox, Abigail
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 11.12.2020; BioMed Central; BMC
• Subjects: Airway; Analysis; Animal model; Animals; Annotations; Cations; Cellular stress response; Chloride ions; Dehydration; Dehydration (Physiology); Diagnosis; Dysphonia; Gene expression; Gene Expression Profiling; Gene sequencing; Genes; Genetic aspects; Genomics; Health aspects; Human subjects; Humidity; In vivo; In vivo methods and tests; Inflammation; Inflammatory response; Ion channels; Ion flux; Larynx; Macrophages; Male; Matrix metalloproteinase; Matrix metalloproteinases; Metalloproteinase; Muscle function; Peptide mapping; Physiological aspects; Physiology; Principal components analysis; Protein folding; Proteins; Rabbits; Ribonucleic acid; Risk factors; RNA; RNA sequencing; RNA-Seq; Sequence Analysis, RNA; Statistical analysis; Testing; Transcription; Vocal Cords; Vocal folds; Vocal organs; Voice; Voice disorders; United States; United States > US; Animal model; In vivo; Dehydration; RNA-Seq; Vocal folds; Airway

Voice disorders are a worldwide problem impacting human health, particularly for occupational voice users. Avoidance of surface dehydration is commonly prescribed as a protective factor against the development of dysphonia. The available literature inconclusively supports this practice and a biologi...