Dual Endothelin Receptor Blockade Acutely Improves Insulin Sensitivity in Obese Patients With Insulin Resistance and Coronary Artery Disease

• Published in: Diabetes care Vol. 30; no. 3; pp. 591 - 596
• Main Authors: Ahlborg, Gunvor, Shemyakin, Alexey, Böhm, Felix, Gonon, Adrian, Pernow, John
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.03.2007
• Subjects: Antihypertensive Agents - therapeutic use; Biological and medical sciences; Blood Glucose - metabolism; Blood Pressure - drug effects; Cardiovascular disease; Coronary Disease - blood; Coronary Disease - complications; Coronary Disease - physiopathology; Diabetes; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - drug therapy; Diabetes Mellitus, Type 2 - physiopathology; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Endothelin Receptor Antagonists; Glucose Clamp Technique; Glucose Intolerance - blood; Glucose Intolerance - physiopathology; Heart Rate - drug effects; Humans; Insulin; Insulin - blood; Insulin - pharmacology; Insulin Resistance; Medical sciences; Medicin och hälsovetenskap; Metabolic diseases; Middle Aged; Obesity; Obesity - complications; Obesity - physiopathology; Oligopeptides - therapeutic use; Peptides, Cyclic - therapeutic use; Piperidines - therapeutic use; Studies; Endocrinopathy; Human; Obesity; Pancreatic hormone; Endothelin; Nutrition disorder; Cardiovascular disease; Coronary heart disease; Insulin; Target tissue resistance; Sensitivity; Insulin resistance; Nutritional status; Biological receptor

OBJECTIVE:--Endothelin (ET)-1 is a vasoconstrictor and proinflammatory peptide that may inhibit glucose uptake. The objective of the study was to investigate if ET (selective ETA and dual ETA+ETB) receptor blockade improves insulin sensitivity in patients with insulin resistance and coronary artery...