The LOX-1 receptor ectopically expressed in the liver alleviates atherosclerosis by clearing Ox-LDL from the circulation

• Published in: Molecular medicine (Cambridge, Mass.) Vol. 28; no. 1; pp. 26 - 15
• Main Authors: Wang, Zhiwen, Chen, Juan, Zeng, Zhuanglin, Zhang, Qing, Du, Gaohui, Guo, Xiaopeng, Wei, Yumiao
• Format: Journal Article
• Language: English
• Published: England BioMed Central 02.03.2022; BMC
• Subjects: AAV8; Animals; Atherosclerosis; Atherosclerosis - metabolism; Cardiovascular disease; Cholesterol; Endothelial Cells - metabolism; Glycoproteins; Intervention; Lipids; Lipoproteins, LDL - metabolism; Liver; Liver - metabolism; Low density lipoprotein; LOX-1; Metabolism; Mice; Ox-LDL; Oxidation; Physiology; Plaque, Atherosclerotic - metabolism; Plaque, Atherosclerotic - pathology; Scavenger Receptors, Class E - genetics; Scavenger Receptors, Class E - metabolism; Vascular Cell Adhesion Molecule-1 - metabolism; Veins & arteries; AAV8; LOX-1; Liver; Atherosclerosis; Ox-LDL

Oxidized Low-Density-Lipoprotein (Ox-LDL) is the core factor in the development of atherosclerosis. However, there are few therapies aimed at eliminating Ox-LDL. Here in this study, we investigate whether the ectopically expression of the lectin-like oxidized low density lipoprotein receptor (LOX-1)...