A hSCARB2-transgenic mouse model for Coxsackievirus A16 pathogenesis

• Published in: Virology journal Vol. 18; no. 1; p. 84
• Main Authors: Chen, Yanli, Li, Heng, Yang, Jinxi, Zheng, Huiwen, Guo, Lei, Li, Weiyu, Yang, Zening, Song, Jie, Liu, Longding
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 21.04.2021; BioMed Central; BMC
• Subjects: Alveoli; Analysis; Animal models; Animals; Antigens; Antigens, Viral; Brain stem; Capillaries; Coxsackievirus; Coxsackievirus A16 (CA16); Coxsackievirus Infections; Coxsackieviruses; Disease Models, Animal; Enterovirus; Foot and mouth disease (HFMD); Hand; Hand-foot-and-mouth disease; Health aspects; Host range; Host-virus relationships; Human scavenger receptor class B; IL-1β; Immune response; Infections; Inflammation; Interleukin 18; Interleukin 6; Laboratory animals; Lymphocytes; Medical research; member 2 (hSCARB2); Mice; Mice, Transgenic; Mucosa; Neurological diseases; Pathogenesis; Pathogenicity; Pathology; Respiratory and neurological pathology; Rodents; Scavenger receptors; Transgenic animals; Transgenic mice; Tropism; Virulence (Microbiology); Virus Replication; Virus research; Viruses; γ-Interferon; China; United States > US; Respiratory and neurological pathology; Foot and mouth disease (HFMD); Coxsackievirus A16 (CA16); Human scavenger receptor class B; Hand; member 2 (hSCARB2)

Coxsackievirus A16 (CA16) is one of the neurotropic pathogen that has been associated with severe neurological forms of hand, foot, and mouth disease (HFMD), but its pathogenesis is not yet clear. The limited host range of CA16 make the establishment of a suitable animal model that can recapitulate...