Contribution of genetic and epigenetic changes to escape from X-chromosome inactivation

• Published in: Epigenetics & chromatin Vol. 14; no. 1; pp. 30 - 22
• Main Authors: Balaton, Bradley P., Brown, Carolyn J.
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 29.06.2021; BioMed Central; BMC
• Subjects: Animals; Cancer; Chromatin; Comparative analysis; CpG Islands; Datasets; Deoxyribonucleic acid; DNA; DNA Methylation; Epigenesis, Genetic; Epigenetic inheritance; Epigenetics; Gene polymorphism; Gene silencing; Genes; Genetic polymorphisms; Genomes; H3K27me3; H3K4me3; Histone marks; Histones; Males; Methylation; RNA polymerase; X Chromosome - genetics; X Chromosome Inactivation; X chromosomes; Escape; Inactivation status; H3K4me3; H3K9me3; DNA methylation; Epigenetics; X-chromosome inactivation; H3K27me3; Histone marks

X-chromosome inactivation (XCI) is the epigenetic inactivation of one of two X chromosomes in XX eutherian mammals. The inactive X chromosome is the result of multiple silencing pathways that act in concert to deposit chromatin changes, including DNA methylation and histone modifications. Yet over 1...