Autophagy blockade synergistically enhances nanosonosensitizer-enabled sonodynamic cancer nanotherapeutics

• Published in: Journal of nanobiotechnology Vol. 19; no. 1; pp. 112 - 15
• Main Authors: Zhou, Liqiang, Huo, Minfeng, Qian, Xiaoqin, Ding, Li, Yu, Luodan, Feng, Wei, Cui, Xinwu, Chen, Yu
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 20.04.2021; BioMed Central; BMC
• Subjects: Animal models; Animals; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Apoptosis; Apoptosis - drug effects; Apoptosis - radiation effects; Autophagy; Autophagy (Cytology); Autophagy - drug effects; Autophagy inhibition; Biotechnology; Cancer; Cancer therapies; Care and treatment; Cell culture; Cell Line, Tumor; Cell survival; Combinatorial analysis; Female; Health aspects; Humans; Kinases; MAP kinase; MCF-7 Cells; Mice; Mice, Inbred BALB C; Mice, Nude; Nanoliposomes; Nanoparticles; Nanoparticles - chemistry; Nanoparticles - therapeutic use; Neoplasms - therapy; Oxidation resistance; Oxidative stress; Phagocytosis; Polyethylene glycol; Proteins; Protoporphyrin; Protoporphyrin IX; Protoporphyrins - pharmacology; Radiation; Radiation-Sensitizing Agents; Signal transduction; Signaling; Sonication - methods; Sonodynamic therapy; Survival; Synergistic effect; Transcriptome; Tumor therapy; Tumors; Ultrasonic imaging; Ultrasonic Therapy - methods; Ultrasonics in medicine; Ultrasound; China; United States > US; Nanoliposomes; Autophagy; Tumor therapy; Autophagy inhibition; Sonodynamic therapy

Ultrasound-triggered sonodynamic therapy (SDT) represents an emerging therapeutic modality for cancer treatment based on its specific feature of noninvasiveness, high tissue-penetrating depth and desirable therapeutic efficacy, but the SDT-induced pro-survival cancer-cell autophagy would significant...