Why are depressed patients inflamed? A reflection on 20 years of research on depression, glucocorticoid resistance and inflammation

• Published in: European neuropsychopharmacology Vol. 27; no. 6; pp. 554 - 559
• Main Author: Pariante, Carmine M.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.06.2017
• Subjects: Anti-Inflammatory Agents - metabolism; Anti-Inflammatory Agents - therapeutic use; Antidepressants; Biomedical Research - trends; Childhood trauma; Depression - drug therapy; Depression - metabolism; Depression - psychology; Glucocorticoid receptor; Glucocorticoids - metabolism; Glucocorticoids - therapeutic use; HPA; Humans; Hydrocortisone - metabolism; Hypothalamo-Hypophyseal System - metabolism; Immunopsychiatry; Inflammation - drug therapy; Inflammation - metabolism; Inflammation - psychology; Inflammation Mediators - metabolism; Internal Medicine; Metabolism, Inborn Errors - drug therapy; Metabolism, Inborn Errors - metabolism; Metabolism, Inborn Errors - psychology; mRNA; Pituitary-Adrenal System - metabolism; Psychiatry; Psychoneuroimmunology; Receptors, Glucocorticoid - deficiency; Receptors, Glucocorticoid - metabolism; Time Factors; Immunopsychiatry; Antidepressants; Glucocorticoid receptor; HPA; mRNA; Psychoneuroimmunology; Childhood trauma

Studies over the last 20 years have demonstrated that increased inflammation and hyperactivity of the hypothalamic–pituitary–adrenal (HPA) axis are two of the most consistent biological findings in major depression and are often associated: but the molecular and clinical mechanisms underlying these...