Association of SMAD7 genetic markers and haplotypes with colorectal cancer risk

• Published in: BMC medical genomics Vol. 15; no. 1; p. 8
• Main Authors: Alidoust, Maryam, Hamzehzadeh, Leila, Khorshid Shamshiri, Asma, Afzaljavan, Fahimeh, Kerachian, Mohammad Amin, Fanipakdel, Azar, Aledavood, Seyed Amir, Allahyari, Abolghasem, Bari, Alireza, Moosanen Mozaffari, Hooman, Goshayeshi, Ladan, Pasdar, Alireza
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 11.01.2022; BioMed Central; BMC
• Subjects: Age; Analysis; Association study; Cancer; Care and treatment; Case-Control Studies; Colonoscopy; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - epidemiology; Colorectal Neoplasms - genetics; Developing countries; Diagnosis; Disease; Etiology; Genetic diversity; Genetic factors; Genetic Markers; Genetic polymorphisms; Genetic Predisposition to Disease; Genomes; Genotype; GWAS; Haplotypes; Humans; Identification and classification; LDCs; Polymorphism, Single Nucleotide; Polymorphisms; Population genetics; Precision medicine; Risk Factors; Single-nucleotide polymorphism; SMAD7; Smad7 protein; Smad7 Protein - genetics; Smad7 Protein - metabolism; Transforming growth factors; Iran; United States > US; Association study; GWAS; Polymorphisms; Colorectal cancer; SMAD7

Colorectal cancer (CRC) is one of the common cancers with a high mortality rate worldwide. In Iran, there has been a trend of increased incidence of colorectal cancer in the last three decades that necessitates the early diagnosis. Genetic factors have an influential role in its etiology along with...