NEDD8 promotes radioresistance via triggering autophagy formation and serves as a novel prognostic marker in oral squamous cell carcinoma

• Published in: Cancer cell international Vol. 23; no. 1; pp. 41 - 14
• Main Authors: Yuan, Tsu-Zong, Lin, Hui-Yu, Kuei, Chia-Hao, Lin, Che-Hsuan, Lee, Hsun-Hua, Lee, Hsin-Lun, Lu, Hsiao-Wei, Su, Chia-Yi, Chiu, Hui-Wen, Lin, Yuan-Feng
• Format: Journal Article
• Language: English
• Published: England BioMed Central 08.03.2023; BMC
• Subjects: AKT protein; Autophagy; Biobanks; Biomarkers; Gene expression; Gene set enrichment analysis; Genomes; Infections; Medical prognosis; Oral cancer; Oral carcinoma; Oral squamous cell carcinoma; Patients; Radiation therapy; Radioresistance; Radiosensitivity; Software; Squamous cell carcinoma; Statistical significance; TOR protein; Tumors

Radiotherapy is the first-line regimen for treating oral squamous cell carcinoma (OSCC) in current clinics. However, the development of therapeutic resistance impacts the anticancer efficacy of irradiation in a subpopulation of OSCC patients. As a result, discovering a valuable biomarker to predict...