Increased levels of microparticles originating from endothelial cells, platelets and erythrocytes in subjects with metabolic syndrome: Relationship with oxidative stress

• Published in: Nutrition, metabolism, and cardiovascular diseases Vol. 21; no. 9; pp. 665 - 671
• Main Authors: Helal, O., Defoort, C., Robert, S., Marin, C., Lesavre, N., Lopez-Miranda, J., Risérus, U., Basu, S., Lovegrove, J., McMonagle, J., Roche, H.M., Dignat-George, F., Lairon, D.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2011; Elsevier
• Subjects: 8-Iso-prostaglandin F 2 α; 8-Iso-prostaglandin F alpha; Adult; Aged; Biomarkers; Biomarkers - blood; blood; blood glucose; Blood Platelets; Blood Platelets - metabolism; Blood Platelets - pathology; blood pressure; Cardiology and cardiovascular system; Cardiovascular; Case-Control Studies; Cell-Derived Microparticles; Cell-Derived Microparticles - metabolism; Cell-Derived Microparticles - pathology; correlation; endothelial cells; Endothelial Cells - metabolism; Endothelial Cells - pathology; Endothelial microparticles; erythrocytes; Erythrocytes - metabolism; Erythrocytes microparticles; Female; Flow Cytometry; glutathione; Glutathione peroxydase; granulocytes; Human health and pathology; Humans; hyperlipidemia; Interleukin-6; Interleukin-6 - blood; Life Sciences; Linear Models; Male; Metabolic syndrome; Metabolic Syndrome - blood; Metabolic Syndrome - pathology; metabolism; Middle Aged; multivariate analysis; Oxidative Stress; pathogenesis; pathology; Platelets microparticles; risk; risk assessment; Tumor Necrosis Factor-alpha; Tumor Necrosis Factor-alpha - blood; Vascular Cell Adhesion Molecule-1; Vascular Cell Adhesion Molecule-1 - blood; waist; Platelets microparticles; MP; PNMP; EMP; Metabolic syndrome; LMP; Glutathione peroxydase; 8-Iso-prostaglandin F 2 α; ErMP; PMP; MetS; TMP; Endothelial microparticles; Erythrocytes microparticles; microparticles; total microparticles for AnnexinV positive microparticles; polymorphonuclear microparticles for granulocytes microparticles; leukocyte microparticles; PLATELETS MICROPARTICLES; METABOLIC SYNDROME; ERYTHROCYTES MICROPARTICLES; 8-ISOPROSTAGLANDIN; CYTOMETRIE EN FLUX; ENDOTHELIAL MICROPARTICLES; GLUTATHIONE PEROXYDASE

The Metabolic Syndrome (MetS) is associated with increased cardiovascular risk. Circulating microparticles (MP) are involved in the pathogenesis of atherothrombotic disorders and are raised in individual with CVD. We measured their level and cellular origin in subjects with MetS and analyzed their a...