Musashi-1 promotes cancer stem cell properties of glioblastoma cells via upregulation of YTHDF1

• Published in: Cancer cell international Vol. 20; no. 1; p. 597
• Main Authors: Yarmishyn, Aliaksandr A, Yang, Yi-Ping, Lu, Kai-Hsi, Chen, Yi-Chen, Chien, Yueh, Chou, Shih-Jie, Tsai, Ping-Hsing, Ma, Hsin-I, Chien, Chian-Shiu, Chen, Ming-Teh, Wang, Mong-Lien
• Format: Journal Article
• Language: English
• Published: England BioMed Central 14.12.2020; BMC
• Subjects: Antibodies; Brain cancer; Brain tumors; Cancer progression; Cellulose acetate; Chemoresistance; Chemotherapy; DNA microarrays; Epigenetics; Gene expression; Glioblastoma; Glioblastoma cells; Glioma; Malignancy; Medical prognosis; Morbidity; Musashi protein; Musashi-1; N6-methyladenosine; Phenotypes; Primary Research; Proteins; Reagents; Ribonucleic acid; RNA; RNA modification; Stem cells; Tumors; Up-regulation; YTHDF1; United States > US; Chicago Illinois; Cancer progression; YTHDF1; Musashi-1; Glioblastoma

Glioblastoma (GBM) is the most lethal brain tumor characterized by high morbidity and limited treatment options. Tumor malignancy is usually associated with the epigenetic marks, which coordinate gene expression to ascertain relevant phenotypes. One of such marks is m6A modification of RNA, whose fu...