Linker histone variant H1t is closely associated with repressed repeat-element chromatin domains in pachytene spermatocytes
H1t is the major linker histone variant in pachytene spermatocytes, where it constitutes 50-60% of total H1. This linker histone variant was previously reported to localize in the nucleolar rDNA element in mouse spermatocytes. Our main aim was to determine the extra-nucleolar localization of this li...
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Published in | Epigenetics & chromatin Vol. 13; no. 1; p. 9 |
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Language | English |
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04.03.2020
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Abstract | H1t is the major linker histone variant in pachytene spermatocytes, where it constitutes 50-60% of total H1. This linker histone variant was previously reported to localize in the nucleolar rDNA element in mouse spermatocytes. Our main aim was to determine the extra-nucleolar localization of this linker histone variant in pachytene spermatocytes.
We generated H1t-specific antibodies in rabbits and validated its specificity by multiple assays like ELISA, western blot, etc. Genome-wide occupancy studies, as determined by ChIP-sequencing in P20 mouse testicular cells revealed that H1t did not closely associate with active gene promoters and open chromatin regions. Annotation of H1t-bound genomic regions revealed that H1t is depleted from DSB hotspots and TSS, but are predominantly associated with retrotransposable repeat elements like LINE and LTR in pachytene spermatocytes. These chromatin domains are repressed based on co-association of H1t observed with methylated CpGs and repressive histone marks like H3K9me3 and H4K20me3 in vivo. Mass spectrometric analysis of proteins associated with H1t-containing oligonucleosomes identified piRNA-PIWI pathway proteins, repeat repression-associated proteins and heterochromatin proteins confirming the association with repressed repeat-element genomic regions. We validated the interaction of key proteins with H1t-containing oligonucleosomes by use of ChIP-western blot assays. On the other hand, we observe majority of H1t peaks to be associated with the intergenic spacer of the rDNA element, also in association with SINE elements of the rDNA element. Thus, we have identified the genomic and chromatin features of both nucleolar and extranucleolar localization patterns of linker histone H1t in the context of pachytene spermatocytes.
H1t-containing repeat-element LINE and LTR chromatin domains are associated with repressive marks like methylated CpGs, histone modifications H3K9me3 and H4K20me3, and heterochromatin proteins like HP1β, Trim28, PIWIL1, etc. Apart from localization of H1t at the rDNA element, we demonstrate the extranucleolar association of this linker histone variant at repeat-associated chromatin domains in pachytene spermatocytes. We hypothesize that H1t might induce local chromatin relaxation to recruit heterochromatin and repeat repression-associated protein factors necessary for TE (transposable element) repression, the final biological effect being formation of closed chromatin repressed structures. |
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AbstractList | BACKGROUNDH1t is the major linker histone variant in pachytene spermatocytes, where it constitutes 50-60% of total H1. This linker histone variant was previously reported to localize in the nucleolar rDNA element in mouse spermatocytes. Our main aim was to determine the extra-nucleolar localization of this linker histone variant in pachytene spermatocytes. RESULTSWe generated H1t-specific antibodies in rabbits and validated its specificity by multiple assays like ELISA, western blot, etc. Genome-wide occupancy studies, as determined by ChIP-sequencing in P20 mouse testicular cells revealed that H1t did not closely associate with active gene promoters and open chromatin regions. Annotation of H1t-bound genomic regions revealed that H1t is depleted from DSB hotspots and TSS, but are predominantly associated with retrotransposable repeat elements like LINE and LTR in pachytene spermatocytes. These chromatin domains are repressed based on co-association of H1t observed with methylated CpGs and repressive histone marks like H3K9me3 and H4K20me3 in vivo. Mass spectrometric analysis of proteins associated with H1t-containing oligonucleosomes identified piRNA-PIWI pathway proteins, repeat repression-associated proteins and heterochromatin proteins confirming the association with repressed repeat-element genomic regions. We validated the interaction of key proteins with H1t-containing oligonucleosomes by use of ChIP-western blot assays. On the other hand, we observe majority of H1t peaks to be associated with the intergenic spacer of the rDNA element, also in association with SINE elements of the rDNA element. Thus, we have identified the genomic and chromatin features of both nucleolar and extranucleolar localization patterns of linker histone H1t in the context of pachytene spermatocytes. CONCLUSIONSH1t-containing repeat-element LINE and LTR chromatin domains are associated with repressive marks like methylated CpGs, histone modifications H3K9me3 and H4K20me3, and heterochromatin proteins like HP1β, Trim28, PIWIL1, etc. Apart from localization of H1t at the rDNA element, we demonstrate the extranucleolar association of this linker histone variant at repeat-associated chromatin domains in pachytene spermatocytes. We hypothesize that H1t might induce local chromatin relaxation to recruit heterochromatin and repeat repression-associated protein factors necessary for TE (transposable element) repression, the final biological effect being formation of closed chromatin repressed structures. Background H1t is the major linker histone variant in pachytene spermatocytes, where it constitutes 50-60% of total H1. This linker histone variant was previously reported to localize in the nucleolar rDNA element in mouse spermatocytes. Our main aim was to determine the extra-nucleolar localization of this linker histone variant in pachytene spermatocytes. Results We generated H1t-specific antibodies in rabbits and validated its specificity by multiple assays like ELISA, western blot, etc. Genome-wide occupancy studies, as determined by ChIP-sequencing in P20 mouse testicular cells revealed that H1t did not closely associate with active gene promoters and open chromatin regions. Annotation of H1t-bound genomic regions revealed that H1t is depleted from DSB hotspots and TSS, but are predominantly associated with retrotransposable repeat elements like LINE and LTR in pachytene spermatocytes. These chromatin domains are repressed based on co-association of H1t observed with methylated CpGs and repressive histone marks like H3K9me3 and H4K20me3 in vivo. Mass spectrometric analysis of proteins associated with H1t-containing oligonucleosomes identified piRNA-PIWI pathway proteins, repeat repression-associated proteins and heterochromatin proteins confirming the association with repressed repeat-element genomic regions. We validated the interaction of key proteins with H1t-containing oligonucleosomes by use of ChIP-western blot assays. On the other hand, we observe majority of H1t peaks to be associated with the intergenic spacer of the rDNA element, also in association with SINE elements of the rDNA element. Thus, we have identified the genomic and chromatin features of both nucleolar and extranucleolar localization patterns of linker histone H1t in the context of pachytene spermatocytes. Conclusions H1t-containing repeat-element LINE and LTR chromatin domains are associated with repressive marks like methylated CpGs, histone modifications H3K9me3 and H4K20me3, and heterochromatin proteins like HP1[beta], Trim28, PIWIL1, etc. Apart from localization of H1t at the rDNA element, we demonstrate the extranucleolar association of this linker histone variant at repeat-associated chromatin domains in pachytene spermatocytes. We hypothesize that H1t might induce local chromatin relaxation to recruit heterochromatin and repeat repression-associated protein factors necessary for TE (transposable element) repression, the final biological effect being formation of closed chromatin repressed structures. Keywords: Linker histones, H1t, LTR, LINE, Histone variants, Mammalian spermatogenesis H1t is the major linker histone variant in pachytene spermatocytes, where it constitutes 50-60% of total H1. This linker histone variant was previously reported to localize in the nucleolar rDNA element in mouse spermatocytes. Our main aim was to determine the extra-nucleolar localization of this linker histone variant in pachytene spermatocytes. We generated H1t-specific antibodies in rabbits and validated its specificity by multiple assays like ELISA, western blot, etc. Genome-wide occupancy studies, as determined by ChIP-sequencing in P20 mouse testicular cells revealed that H1t did not closely associate with active gene promoters and open chromatin regions. Annotation of H1t-bound genomic regions revealed that H1t is depleted from DSB hotspots and TSS, but are predominantly associated with retrotransposable repeat elements like LINE and LTR in pachytene spermatocytes. These chromatin domains are repressed based on co-association of H1t observed with methylated CpGs and repressive histone marks like H3K9me3 and H4K20me3 in vivo. Mass spectrometric analysis of proteins associated with H1t-containing oligonucleosomes identified piRNA-PIWI pathway proteins, repeat repression-associated proteins and heterochromatin proteins confirming the association with repressed repeat-element genomic regions. We validated the interaction of key proteins with H1t-containing oligonucleosomes by use of ChIP-western blot assays. On the other hand, we observe majority of H1t peaks to be associated with the intergenic spacer of the rDNA element, also in association with SINE elements of the rDNA element. Thus, we have identified the genomic and chromatin features of both nucleolar and extranucleolar localization patterns of linker histone H1t in the context of pachytene spermatocytes. H1t-containing repeat-element LINE and LTR chromatin domains are associated with repressive marks like methylated CpGs, histone modifications H3K9me3 and H4K20me3, and heterochromatin proteins like HP1β, Trim28, PIWIL1, etc. Apart from localization of H1t at the rDNA element, we demonstrate the extranucleolar association of this linker histone variant at repeat-associated chromatin domains in pachytene spermatocytes. We hypothesize that H1t might induce local chromatin relaxation to recruit heterochromatin and repeat repression-associated protein factors necessary for TE (transposable element) repression, the final biological effect being formation of closed chromatin repressed structures. Abstract Background H1t is the major linker histone variant in pachytene spermatocytes, where it constitutes 50–60% of total H1. This linker histone variant was previously reported to localize in the nucleolar rDNA element in mouse spermatocytes. Our main aim was to determine the extra-nucleolar localization of this linker histone variant in pachytene spermatocytes. Results We generated H1t-specific antibodies in rabbits and validated its specificity by multiple assays like ELISA, western blot, etc. Genome-wide occupancy studies, as determined by ChIP-sequencing in P20 mouse testicular cells revealed that H1t did not closely associate with active gene promoters and open chromatin regions. Annotation of H1t-bound genomic regions revealed that H1t is depleted from DSB hotspots and TSS, but are predominantly associated with retrotransposable repeat elements like LINE and LTR in pachytene spermatocytes. These chromatin domains are repressed based on co-association of H1t observed with methylated CpGs and repressive histone marks like H3K9me3 and H4K20me3 in vivo. Mass spectrometric analysis of proteins associated with H1t-containing oligonucleosomes identified piRNA–PIWI pathway proteins, repeat repression-associated proteins and heterochromatin proteins confirming the association with repressed repeat-element genomic regions. We validated the interaction of key proteins with H1t-containing oligonucleosomes by use of ChIP-western blot assays. On the other hand, we observe majority of H1t peaks to be associated with the intergenic spacer of the rDNA element, also in association with SINE elements of the rDNA element. Thus, we have identified the genomic and chromatin features of both nucleolar and extranucleolar localization patterns of linker histone H1t in the context of pachytene spermatocytes. Conclusions H1t-containing repeat-element LINE and LTR chromatin domains are associated with repressive marks like methylated CpGs, histone modifications H3K9me3 and H4K20me3, and heterochromatin proteins like HP1β, Trim28, PIWIL1, etc. Apart from localization of H1t at the rDNA element, we demonstrate the extranucleolar association of this linker histone variant at repeat-associated chromatin domains in pachytene spermatocytes. We hypothesize that H1t might induce local chromatin relaxation to recruit heterochromatin and repeat repression-associated protein factors necessary for TE (transposable element) repression, the final biological effect being formation of closed chromatin repressed structures. Background H1t is the major linker histone variant in pachytene spermatocytes, where it constitutes 50–60% of total H1. This linker histone variant was previously reported to localize in the nucleolar rDNA element in mouse spermatocytes. Our main aim was to determine the extra-nucleolar localization of this linker histone variant in pachytene spermatocytes. Results We generated H1t-specific antibodies in rabbits and validated its specificity by multiple assays like ELISA, western blot, etc. Genome-wide occupancy studies, as determined by ChIP-sequencing in P20 mouse testicular cells revealed that H1t did not closely associate with active gene promoters and open chromatin regions. Annotation of H1t-bound genomic regions revealed that H1t is depleted from DSB hotspots and TSS, but are predominantly associated with retrotransposable repeat elements like LINE and LTR in pachytene spermatocytes. These chromatin domains are repressed based on co-association of H1t observed with methylated CpGs and repressive histone marks like H3K9me3 and H4K20me3 in vivo. Mass spectrometric analysis of proteins associated with H1t-containing oligonucleosomes identified piRNA–PIWI pathway proteins, repeat repression-associated proteins and heterochromatin proteins confirming the association with repressed repeat-element genomic regions. We validated the interaction of key proteins with H1t-containing oligonucleosomes by use of ChIP-western blot assays. On the other hand, we observe majority of H1t peaks to be associated with the intergenic spacer of the rDNA element, also in association with SINE elements of the rDNA element. Thus, we have identified the genomic and chromatin features of both nucleolar and extranucleolar localization patterns of linker histone H1t in the context of pachytene spermatocytes. Conclusions H1t-containing repeat-element LINE and LTR chromatin domains are associated with repressive marks like methylated CpGs, histone modifications H3K9me3 and H4K20me3, and heterochromatin proteins like HP1β, Trim28, PIWIL1, etc. Apart from localization of H1t at the rDNA element, we demonstrate the extranucleolar association of this linker histone variant at repeat-associated chromatin domains in pachytene spermatocytes. We hypothesize that H1t might induce local chromatin relaxation to recruit heterochromatin and repeat repression-associated protein factors necessary for TE (transposable element) repression, the final biological effect being formation of closed chromatin repressed structures. H1t is the major linker histone variant in pachytene spermatocytes, where it constitutes 50-60% of total H1. This linker histone variant was previously reported to localize in the nucleolar rDNA element in mouse spermatocytes. Our main aim was to determine the extra-nucleolar localization of this linker histone variant in pachytene spermatocytes. We generated H1t-specific antibodies in rabbits and validated its specificity by multiple assays like ELISA, western blot, etc. Genome-wide occupancy studies, as determined by ChIP-sequencing in P20 mouse testicular cells revealed that H1t did not closely associate with active gene promoters and open chromatin regions. Annotation of H1t-bound genomic regions revealed that H1t is depleted from DSB hotspots and TSS, but are predominantly associated with retrotransposable repeat elements like LINE and LTR in pachytene spermatocytes. These chromatin domains are repressed based on co-association of H1t observed with methylated CpGs and repressive histone marks like H3K9me3 and H4K20me3 in vivo. Mass spectrometric analysis of proteins associated with H1t-containing oligonucleosomes identified piRNA-PIWI pathway proteins, repeat repression-associated proteins and heterochromatin proteins confirming the association with repressed repeat-element genomic regions. We validated the interaction of key proteins with H1t-containing oligonucleosomes by use of ChIP-western blot assays. On the other hand, we observe majority of H1t peaks to be associated with the intergenic spacer of the rDNA element, also in association with SINE elements of the rDNA element. Thus, we have identified the genomic and chromatin features of both nucleolar and extranucleolar localization patterns of linker histone H1t in the context of pachytene spermatocytes. H1t-containing repeat-element LINE and LTR chromatin domains are associated with repressive marks like methylated CpGs, histone modifications H3K9me3 and H4K20me3, and heterochromatin proteins like HP1[beta], Trim28, PIWIL1, etc. Apart from localization of H1t at the rDNA element, we demonstrate the extranucleolar association of this linker histone variant at repeat-associated chromatin domains in pachytene spermatocytes. We hypothesize that H1t might induce local chromatin relaxation to recruit heterochromatin and repeat repression-associated protein factors necessary for TE (transposable element) repression, the final biological effect being formation of closed chromatin repressed structures. Abstract Background H1t is the major linker histone variant in pachytene spermatocytes, where it constitutes 50–60% of total H1. This linker histone variant was previously reported to localize in the nucleolar rDNA element in mouse spermatocytes. Our main aim was to determine the extra-nucleolar localization of this linker histone variant in pachytene spermatocytes. Results We generated H1t-specific antibodies in rabbits and validated its specificity by multiple assays like ELISA, western blot, etc. Genome-wide occupancy studies, as determined by ChIP-sequencing in P20 mouse testicular cells revealed that H1t did not closely associate with active gene promoters and open chromatin regions. Annotation of H1t-bound genomic regions revealed that H1t is depleted from DSB hotspots and TSS, but are predominantly associated with retrotransposable repeat elements like LINE and LTR in pachytene spermatocytes. These chromatin domains are repressed based on co-association of H1t observed with methylated CpGs and repressive histone marks like H3K9me3 and H4K20me3 in vivo. Mass spectrometric analysis of proteins associated with H1t-containing oligonucleosomes identified piRNA–PIWI pathway proteins, repeat repression-associated proteins and heterochromatin proteins confirming the association with repressed repeat-element genomic regions. We validated the interaction of key proteins with H1t-containing oligonucleosomes by use of ChIP-western blot assays. On the other hand, we observe majority of H1t peaks to be associated with the intergenic spacer of the rDNA element, also in association with SINE elements of the rDNA element. Thus, we have identified the genomic and chromatin features of both nucleolar and extranucleolar localization patterns of linker histone H1t in the context of pachytene spermatocytes. Conclusions H1t-containing repeat-element LINE and LTR chromatin domains are associated with repressive marks like methylated CpGs, histone modifications H3K9me3 and H4K20me3, and heterochromatin proteins like HP1β, Trim28, PIWIL1, etc. Apart from localization of H1t at the rDNA element, we demonstrate the extranucleolar association of this linker histone variant at repeat-associated chromatin domains in pachytene spermatocytes. We hypothesize that H1t might induce local chromatin relaxation to recruit heterochromatin and repeat repression-associated protein factors necessary for TE (transposable element) repression, the final biological effect being formation of closed chromatin repressed structures. |
ArticleNumber | 9 |
Audience | Academic |
Author | Rao, Manchanahalli R Satyanarayana Mahadevan, Iyer Aditya Kumar, Sanjeev |
Author_xml | – sequence: 1 givenname: Iyer Aditya surname: Mahadevan fullname: Mahadevan, Iyer Aditya organization: Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, India – sequence: 2 givenname: Sanjeev surname: Kumar fullname: Kumar, Sanjeev organization: BioCOS Life Sciences Private Limited, SAAMI Building, 851/A, AECS Layout, B-Block, Singasandra Hosur Road, Bangalore, India – sequence: 3 givenname: Manchanahalli R Satyanarayana orcidid: 0000-0003-0201-9437 surname: Rao fullname: Rao, Manchanahalli R Satyanarayana email: mrsrao@jncasr.ac.in organization: Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, India. mrsrao@jncasr.ac.in |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32131873$$D View this record in MEDLINE/PubMed |
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CitedBy_id | crossref_primary_10_3390_genes12101562 crossref_primary_10_1007_s00412_023_00803_9 crossref_primary_10_1007_s11356_023_25874_0 crossref_primary_10_1016_j_bbrc_2020_05_119 crossref_primary_10_1186_s12885_023_11426_9 crossref_primary_10_1016_j_jid_2021_04_002 crossref_primary_10_1242_dev_196477 crossref_primary_10_3389_fcell_2021_674203 crossref_primary_10_1186_s13072_020_00376_2 crossref_primary_10_1242_jcs_244749 |
Cites_doi | 10.1074/jbc.M400070200 10.1101/gad.220095.113 10.1093/nar/gkg481 10.1016/j.molcel.2016.06.008 10.1002/j.1460-2075.1989.tb03440.x 10.1016/j.cell.2018.05.043 10.1534/g3.113.009290 10.1371/journal.pgen.1000889 10.1095/biolreprod64.2.425 10.1038/nature10672 10.1016/j.cell.2013.02.001 10.1111/j.1365-2443.2009.01342.x 10.1128/MCB.20.6.2122-2128.2000 10.1038/ncb2113 10.1007/BF02484408 10.1016/0014-4827(82)90162-8 10.1111/j.1432-1033.2004.04266.x 10.1016/S0092-8674(01)00542-6 10.1016/0012-1606(84)90009-5 10.1038/nprot.2007.202 10.1023/A:1018445520117 10.1016/j.devcel.2014.05.024 10.1080/15592294.2016.1159369 10.1038/nrg3454 10.1038/nature02886 10.1007/s004410050986 10.1021/bi00048a025 10.1146/annurev-genom-091212-153515 10.1371/journal.pgen.1000635 10.1186/s13072-016-0072-6 10.1002/prot.10204 10.1016/bs.mie.2016.09.031 10.1016/0378-1119(91)90284-I 10.1016/j.febslet.2006.09.061 10.1016/S0888-7543(03)00199-X 10.1091/mbc.e10-06-0508 10.1093/nar/gkl198 10.1016/j.cell.2005.10.028 10.1016/j.celrep.2015.07.060 10.1016/j.devcel.2009.10.012 10.1101/802173 10.1016/j.ceb.2013.10.002 10.1093/nar/gkx1052 10.1038/emboj.2013.121 10.1021/bi961617p 10.1093/nar/gkt863 10.1038/bjc.1963.24 10.1002/(SICI)1097-4644(20000101)76:1<20::AID-JCB3>3.0.CO;2-Y 10.1038/sj.emboj.7601513 10.1111/j.1432-1033.1977.tb11639.x 10.1111/j.1432-1033.1977.tb11975.x 10.1021/bi00618a030 10.1038/nsmb.1615 10.15252/embr.201947952 10.1016/j.devcel.2014.05.023 10.1016/j.bbagrm.2015.09.009 10.1101/gad.240895.114 10.1038/nrm3965 10.1095/biolreprod.110.087361 10.1006/bbrc.1994.1005 10.1111/j.1432-1033.1975.tb02327.x 10.1101/gad.244350.114 10.1186/1471-2164-15-284 10.1016/j.ceb.2005.02.006 10.1186/s13072-018-0214-0 10.1038/s41467-019-12455-4 10.1093/biolre/iox150 10.1371/journal.pone.0178821 10.1038/nmeth.1923 10.1038/nrg2008 10.1016/S0378-1119(02)01201-5 10.1093/molehr/4.10.939 10.1101/gad.257840.114 10.1016/j.molcel.2019.10.011 10.1016/j.celrep.2013.05.003 10.1016/0378-1119(93)90332-W 10.1016/j.cell.2015.02.040 10.1093/bioinformatics/btr167 10.1016/0005-2795(79)90159-4 |
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Keywords | Linker histones H1t LTR Mammalian spermatogenesis Histone variants LINE |
Language | English |
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PublicationTitle | Epigenetics & chromatin |
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References | WA Bickmore (335_CR57) 2013; 152 I Nagamori (335_CR26) 2015; 12 AH Peters (335_CR42) 2005; 17 L Ma (335_CR28) 2009; 5 J Dekker (335_CR59) 2013; 14 J Dong (335_CR47) 2019; 10 TL Bailey (335_CR80) 2006; 34 Y Fan (335_CR51) 2005; 123 WA Bickmore (335_CR58) 2013; 14 DA Fantz (335_CR18) 2001; 64 MM Bharath (335_CR23) 2002; 49 S van Koningsbruggen (335_CR64) 2010; 21 B Drabent (335_CR22) 1991; 103 M Guthmann (335_CR46) 2019; 20 B Samans (335_CR67) 2014; 30 M Reuter (335_CR44) 2011; 480 MM Bharath (335_CR1) 2003; 31 RW Lennox (335_CR9) 1984; 103 E Montellier (335_CR72) 2013; 27 N Zamudio (335_CR50) 2015; 29 MR Faraone-Mennella (335_CR69) 1999; 76 PG Hartman (335_CR4) 1977; 77 M Suzuki (335_CR21) 1989; 8 AK Ghosh (335_CR55) 1993; 125 J Choi (335_CR52) 2020; 77 JR Khadake (335_CR19) 1995; 34 HW Rattle (335_CR6) 1977; 81 SI Grewal (335_CR40) 2007; 8 AH Peters (335_CR76) 1997; 5 M Shoji (335_CR27) 2009; 17 K Steger (335_CR10) 1998; 4 JP Saxe (335_CR45) 2013; 32 YW Iwasaki (335_CR53) 2016; 63 BR Carone (335_CR66) 2014; 30 GE Zentner (335_CR54) 2014; 4 J Hu (335_CR32) 2018; 98 J Govin (335_CR15) 2004; 271 S Maezawa (335_CR35) 2018; 46 K Kojima (335_CR29) 2009; 14 Q Lin (335_CR16) 2000; 20 LR Bucci (335_CR13) 1982; 140 AH Peters (335_CR41) 2001; 107 RT Simpson (335_CR2) 1978; 17 A Nemeth (335_CR63) 2010; 6 T Sexton (335_CR62) 2015; 160 N Gupta (335_CR74) 2017; 586 MJ Hendzel (335_CR8) 2004; 279 S Ramesh (335_CR25) 2006; 580 D Shechter (335_CR75) 2007; 2 F De Lucia (335_CR20) 1994; 198 R Cong (335_CR56) 2014; 42 LJ Luense (335_CR71) 2016; 9 JR Khadake (335_CR24) 1997; 36 FJ Aviles (335_CR5) 1979; 578 M Reuter (335_CR30) 2009; 16 JY Lu (335_CR49) 2019 ML Meyer-Ficca (335_CR70) 2011; 84 LN Mishra (335_CR68) 2018; 11 AS Belmont (335_CR60) 2014; 26 S Dillinger (335_CR65) 2017; 12 B Langmead (335_CR78) 2012; 9 D Bourc’his (335_CR36) 2004; 431 A Roque (335_CR7) 2016; 1859 IA Mahadevan (335_CR81) 2019; 12 F Krueger (335_CR79) 2011; 27 SR Grimes (335_CR14) 2003; 304 R Tani (335_CR31) 2016; 11 D Pezic (335_CR38) 2014; 28 M Percharde (335_CR48) 2018; 174 L Shen (335_CR34) 2014; 15 K Delaval (335_CR39) 2007; 26 M Tardat (335_CR77) 2010; 12 D Burston (335_CR73) 1963; 17 A Molaro (335_CR37) 2014; 28 A Izzo (335_CR33) 2013; 3 B Drabent (335_CR11) 1996; 106 P Grozdanov (335_CR43) 2003; 82 EM Bradbury (335_CR3) 1975; 57 B Drabent (335_CR12) 1998; 291 B Drabent (335_CR17) 2003; 103 A Pombo (335_CR61) 2015; 16 |
References_xml | – volume: 279 start-page: 20028 issue: 19 year: 2004 ident: 335_CR8 publication-title: J Biol Chem doi: 10.1074/jbc.M400070200 contributor: fullname: MJ Hendzel – volume: 27 start-page: 1680 issue: 15 year: 2013 ident: 335_CR72 publication-title: Genes Dev doi: 10.1101/gad.220095.113 contributor: fullname: E Montellier – volume: 31 start-page: 4264 issue: 14 year: 2003 ident: 335_CR1 publication-title: Nucleic Acids Res doi: 10.1093/nar/gkg481 contributor: fullname: MM Bharath – volume: 103 start-page: 307 issue: 3–4 year: 2003 ident: 335_CR17 publication-title: Cytogenet Genome Res. contributor: fullname: B Drabent – volume: 63 start-page: 408 issue: 3 year: 2016 ident: 335_CR53 publication-title: Mol Cell doi: 10.1016/j.molcel.2016.06.008 contributor: fullname: YW Iwasaki – volume: 8 start-page: 797 issue: 3 year: 1989 ident: 335_CR21 publication-title: EMBO J doi: 10.1002/j.1460-2075.1989.tb03440.x contributor: fullname: M Suzuki – volume: 174 start-page: 391 issue: 2 year: 2018 ident: 335_CR48 publication-title: Cell doi: 10.1016/j.cell.2018.05.043 contributor: fullname: M Percharde – volume: 4 start-page: 243 issue: 2 year: 2014 ident: 335_CR54 publication-title: G3. doi: 10.1534/g3.113.009290 contributor: fullname: GE Zentner – volume: 6 start-page: e1000889 issue: 3 year: 2010 ident: 335_CR63 publication-title: PLoS Genet doi: 10.1371/journal.pgen.1000889 contributor: fullname: A Nemeth – volume: 64 start-page: 425 issue: 2 year: 2001 ident: 335_CR18 publication-title: Biol Reprod doi: 10.1095/biolreprod64.2.425 contributor: fullname: DA Fantz – volume: 480 start-page: 264 issue: 7376 year: 2011 ident: 335_CR44 publication-title: Nature doi: 10.1038/nature10672 contributor: fullname: M Reuter – volume: 152 start-page: 1270 issue: 6 year: 2013 ident: 335_CR57 publication-title: Cell doi: 10.1016/j.cell.2013.02.001 contributor: fullname: WA Bickmore – volume: 14 start-page: 1155 issue: 10 year: 2009 ident: 335_CR29 publication-title: Genes Cells doi: 10.1111/j.1365-2443.2009.01342.x contributor: fullname: K Kojima – volume: 20 start-page: 2122 issue: 6 year: 2000 ident: 335_CR16 publication-title: Mol Cell Biol doi: 10.1128/MCB.20.6.2122-2128.2000 contributor: fullname: Q Lin – volume: 12 start-page: 1086 issue: 11 year: 2010 ident: 335_CR77 publication-title: Nat Cell Biol doi: 10.1038/ncb2113 contributor: fullname: M Tardat – volume: 106 start-page: 247 issue: 2 year: 1996 ident: 335_CR11 publication-title: Histochem Cell Biol doi: 10.1007/BF02484408 contributor: fullname: B Drabent – volume: 140 start-page: 111 issue: 1 year: 1982 ident: 335_CR13 publication-title: Exp Cell Res doi: 10.1016/0014-4827(82)90162-8 contributor: fullname: LR Bucci – volume: 271 start-page: 3459 issue: 17 year: 2004 ident: 335_CR15 publication-title: Eur J Biochem doi: 10.1111/j.1432-1033.2004.04266.x contributor: fullname: J Govin – volume: 107 start-page: 323 issue: 3 year: 2001 ident: 335_CR41 publication-title: Cell doi: 10.1016/S0092-8674(01)00542-6 contributor: fullname: AH Peters – volume: 103 start-page: 80 issue: 1 year: 1984 ident: 335_CR9 publication-title: Dev Biol. doi: 10.1016/0012-1606(84)90009-5 contributor: fullname: RW Lennox – volume: 2 start-page: 1445 issue: 6 year: 2007 ident: 335_CR75 publication-title: Nat Protoc doi: 10.1038/nprot.2007.202 contributor: fullname: D Shechter – volume: 5 start-page: 66 issue: 1 year: 1997 ident: 335_CR76 publication-title: Chromosome Res doi: 10.1023/A:1018445520117 contributor: fullname: AH Peters – volume: 30 start-page: 11 issue: 1 year: 2014 ident: 335_CR66 publication-title: Dev Cell doi: 10.1016/j.devcel.2014.05.024 contributor: fullname: BR Carone – volume: 11 start-page: 288 issue: 4 year: 2016 ident: 335_CR31 publication-title: Epigenetics. doi: 10.1080/15592294.2016.1159369 contributor: fullname: R Tani – volume: 14 start-page: 390 issue: 6 year: 2013 ident: 335_CR59 publication-title: Nat Rev Genet doi: 10.1038/nrg3454 contributor: fullname: J Dekker – volume: 431 start-page: 96 issue: 7004 year: 2004 ident: 335_CR36 publication-title: Nature doi: 10.1038/nature02886 contributor: fullname: D Bourc’his – volume: 291 start-page: 127 issue: 1 year: 1998 ident: 335_CR12 publication-title: Cell Tissue Res doi: 10.1007/s004410050986 contributor: fullname: B Drabent – volume: 34 start-page: 15792 issue: 48 year: 1995 ident: 335_CR19 publication-title: Biochemistry doi: 10.1021/bi00048a025 contributor: fullname: JR Khadake – volume: 14 start-page: 67 year: 2013 ident: 335_CR58 publication-title: Annu Rev Genomics Hum Genet doi: 10.1146/annurev-genom-091212-153515 contributor: fullname: WA Bickmore – volume: 5 start-page: e1000635 issue: 9 year: 2009 ident: 335_CR28 publication-title: PLoS Genet doi: 10.1371/journal.pgen.1000635 contributor: fullname: L Ma – volume: 9 start-page: 24 year: 2016 ident: 335_CR71 publication-title: Epigenet Chromat. doi: 10.1186/s13072-016-0072-6 contributor: fullname: LJ Luense – volume: 49 start-page: 71 issue: 1 year: 2002 ident: 335_CR23 publication-title: Proteins. doi: 10.1002/prot.10204 contributor: fullname: MM Bharath – volume: 586 start-page: 115 year: 2017 ident: 335_CR74 publication-title: Methods Enzymol doi: 10.1016/bs.mie.2016.09.031 contributor: fullname: N Gupta – volume: 103 start-page: 263 issue: 2 year: 1991 ident: 335_CR22 publication-title: Gene doi: 10.1016/0378-1119(91)90284-I contributor: fullname: B Drabent – volume: 580 start-page: 5999 issue: 25 year: 2006 ident: 335_CR25 publication-title: FEBS Lett doi: 10.1016/j.febslet.2006.09.061 contributor: fullname: S Ramesh – volume: 82 start-page: 637 issue: 6 year: 2003 ident: 335_CR43 publication-title: Genomics doi: 10.1016/S0888-7543(03)00199-X contributor: fullname: P Grozdanov – volume: 21 start-page: 3735 issue: 21 year: 2010 ident: 335_CR64 publication-title: Mol Biol Cell doi: 10.1091/mbc.e10-06-0508 contributor: fullname: S van Koningsbruggen – volume: 34 start-page: W369 issue: Web Server issu year: 2006 ident: 335_CR80 publication-title: Nucleic Acids Res doi: 10.1093/nar/gkl198 contributor: fullname: TL Bailey – volume: 123 start-page: 1199 issue: 7 year: 2005 ident: 335_CR51 publication-title: Cell doi: 10.1016/j.cell.2005.10.028 contributor: fullname: Y Fan – volume: 12 start-page: 1541 issue: 10 year: 2015 ident: 335_CR26 publication-title: Cell Rep. doi: 10.1016/j.celrep.2015.07.060 contributor: fullname: I Nagamori – volume: 17 start-page: 775 issue: 6 year: 2009 ident: 335_CR27 publication-title: Dev Cell doi: 10.1016/j.devcel.2009.10.012 contributor: fullname: M Shoji – year: 2019 ident: 335_CR49 publication-title: BioRxiv. doi: 10.1101/802173 contributor: fullname: JY Lu – volume: 26 start-page: 69 year: 2014 ident: 335_CR60 publication-title: Curr Opin Cell Biol doi: 10.1016/j.ceb.2013.10.002 contributor: fullname: AS Belmont – volume: 46 start-page: 593 issue: 2 year: 2018 ident: 335_CR35 publication-title: Nucleic Acids Res doi: 10.1093/nar/gkx1052 contributor: fullname: S Maezawa – volume: 32 start-page: 1869 issue: 13 year: 2013 ident: 335_CR45 publication-title: EMBO J doi: 10.1038/emboj.2013.121 contributor: fullname: JP Saxe – volume: 36 start-page: 1041 issue: 5 year: 1997 ident: 335_CR24 publication-title: Biochemistry doi: 10.1021/bi961617p contributor: fullname: JR Khadake – volume: 42 start-page: 181 issue: 1 year: 2014 ident: 335_CR56 publication-title: Nucleic Acids Res doi: 10.1093/nar/gkt863 contributor: fullname: R Cong – volume: 17 start-page: 162 year: 1963 ident: 335_CR73 publication-title: Br J Cancer doi: 10.1038/bjc.1963.24 contributor: fullname: D Burston – volume: 76 start-page: 20 issue: 1 year: 1999 ident: 335_CR69 publication-title: J Cell Biochem doi: 10.1002/(SICI)1097-4644(20000101)76:1<20::AID-JCB3>3.0.CO;2-Y contributor: fullname: MR Faraone-Mennella – volume: 26 start-page: 720 issue: 3 year: 2007 ident: 335_CR39 publication-title: EMBO J doi: 10.1038/sj.emboj.7601513 contributor: fullname: K Delaval – volume: 77 start-page: 45 issue: 1 year: 1977 ident: 335_CR4 publication-title: Eur J Biochem doi: 10.1111/j.1432-1033.1977.tb11639.x contributor: fullname: PG Hartman – volume: 81 start-page: 499 issue: 3 year: 1977 ident: 335_CR6 publication-title: Eur J Biochem doi: 10.1111/j.1432-1033.1977.tb11975.x contributor: fullname: HW Rattle – volume: 17 start-page: 5524 issue: 25 year: 1978 ident: 335_CR2 publication-title: Biochemistry doi: 10.1021/bi00618a030 contributor: fullname: RT Simpson – volume: 16 start-page: 639 issue: 6 year: 2009 ident: 335_CR30 publication-title: Nat Struct Mol Biol doi: 10.1038/nsmb.1615 contributor: fullname: M Reuter – volume: 20 start-page: e47952 year: 2019 ident: 335_CR46 publication-title: EMBO Rep doi: 10.15252/embr.201947952 contributor: fullname: M Guthmann – volume: 30 start-page: 23 issue: 1 year: 2014 ident: 335_CR67 publication-title: Dev Cell doi: 10.1016/j.devcel.2014.05.023 contributor: fullname: B Samans – volume: 1859 start-page: 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issue: 14 year: 2014 ident: 335_CR37 publication-title: Genes Dev doi: 10.1101/gad.244350.114 contributor: fullname: A Molaro – volume: 15 start-page: 284 year: 2014 ident: 335_CR34 publication-title: BMC Genomics. doi: 10.1186/1471-2164-15-284 contributor: fullname: L Shen – volume: 17 start-page: 230 issue: 2 year: 2005 ident: 335_CR42 publication-title: Curr Opin Cell Biol doi: 10.1016/j.ceb.2005.02.006 contributor: fullname: AH Peters – volume: 11 start-page: 1 year: 2018 ident: 335_CR68 publication-title: Epigenet Chromat. doi: 10.1186/s13072-018-0214-0 contributor: fullname: LN Mishra – volume: 12 start-page: 53 issue: 1 year: 2019 ident: 335_CR81 publication-title: EpigenetChromat. contributor: fullname: IA Mahadevan – volume: 10 start-page: 4705 issue: 1 year: 2019 ident: 335_CR47 publication-title: Nat Commun. doi: 10.1038/s41467-019-12455-4 contributor: fullname: J Dong – volume: 98 start-page: 102 issue: 1 year: 2018 ident: 335_CR32 publication-title: Biol Reprod doi: 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start-page: 310 issue: 2 year: 2020 ident: 335_CR52 publication-title: Mol Cell. doi: 10.1016/j.molcel.2019.10.011 contributor: fullname: J Choi – volume: 3 start-page: 2142 issue: 6 year: 2013 ident: 335_CR33 publication-title: Cell Rep. doi: 10.1016/j.celrep.2013.05.003 contributor: fullname: A Izzo – volume: 125 start-page: 217 issue: 2 year: 1993 ident: 335_CR55 publication-title: Gene doi: 10.1016/0378-1119(93)90332-W contributor: fullname: AK Ghosh – volume: 160 start-page: 1049 issue: 6 year: 2015 ident: 335_CR62 publication-title: Cell doi: 10.1016/j.cell.2015.02.040 contributor: fullname: T Sexton – volume: 27 start-page: 1571 issue: 11 year: 2011 ident: 335_CR79 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btr167 contributor: fullname: F Krueger – volume: 578 start-page: 290 issue: 2 year: 1979 ident: 335_CR5 publication-title: Biochim Biophys Acta doi: 10.1016/0005-2795(79)90159-4 contributor: fullname: FJ Aviles |
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Snippet | H1t is the major linker histone variant in pachytene spermatocytes, where it constitutes 50-60% of total H1. This linker histone variant was previously... Abstract Background H1t is the major linker histone variant in pachytene spermatocytes, where it constitutes 50–60% of total H1. This linker histone variant... Background H1t is the major linker histone variant in pachytene spermatocytes, where it constitutes 50-60% of total H1. This linker histone variant was... Background H1t is the major linker histone variant in pachytene spermatocytes, where it constitutes 50–60% of total H1. This linker histone variant was... BACKGROUNDH1t is the major linker histone variant in pachytene spermatocytes, where it constitutes 50-60% of total H1. This linker histone variant was... Abstract Background H1t is the major linker histone variant in pachytene spermatocytes, where it constitutes 50–60% of total H1. This linker histone variant... |
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SubjectTerms | Analysis Animals Antibodies Antigens Binding sites Chromatin Competition CpG Islands Deoxyribonucleic acid DNA DNA binding proteins DNA methylation Enzyme-linked immunosorbent assay Genes Genetic aspects Genomes Genomics H1t Histone Code Histone variants Histones Histones - chemistry Histones - genetics Immunoglobulins LINE Linker histones Localization Long Interspersed Nucleotide Elements LTR Male Mammalian spermatogenesis Mass spectrometry Mice Nucleosomes - chemistry Nucleosomes - genetics Occupancy Pachytene Pachytene Stage Proteins Scientific imaging Spermatocytes Spermatocytes - metabolism Spermatogenesis Stem cells Terminal Repeat Sequences Transposons |
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Title | Linker histone variant H1t is closely associated with repressed repeat-element chromatin domains in pachytene spermatocytes |
URI | https://www.ncbi.nlm.nih.gov/pubmed/32131873 https://www.proquest.com/docview/2378858635 https://search.proquest.com/docview/2371853711 https://pubmed.ncbi.nlm.nih.gov/PMC7057672 https://doaj.org/article/c699e373b4354077b7b1846b97c83761 |
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