Retrotransposon-Induced Heterochromatin Spreading in the Mouse Revealed by Insertional Polymorphisms

• Published in: PLoS genetics Vol. 7; no. 9; pp. e1002301 - 14
• Main Authors: Rebollo, Rita, Karimi, Mohammad M., Bilenky, Misha, Gagnier, Liane, Miceli-Royer, Katharine, Zhang, Ying, Goyal, Preeti, Keane, Thomas M., Jones, Steven, Hirst, Martin, Lorincz, Matthew C., Mager, Dixie L.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.09.2011; Public Library of Science (PLoS)
• Subjects: Animals; Biology; Cell Line; Chromatin Immunoprecipitation; Deoxyribonucleic acid; DNA; DNA methylation; Embryonic Stem Cells - cytology; Epigenesis, Genetic - genetics; Gene Expression Regulation; Gene Silencing; Genetics; Glycosyltransferases - genetics; Glycosyltransferases - metabolism; Heterochromatin - genetics; Heterochromatin - metabolism; Life Sciences; Long Interspersed Nucleotide Elements - genetics; Medical research; Mice; Mutagenesis, Insertional - genetics; Polymorphism, Genetic; Proteins; Retroelements - genetics; Stem cells; chromatin Immunoprecipitation; gene expression regulation; glycosyltransferases; long interspersed nucleotide elements; cell Line; epigenesis; embryonic Stem Cells; gene silencing; animals; mice; heterochromatin

The "arms race" relationship between transposable elements (TEs) and their host has promoted a series of epigenetic silencing mechanisms directed against TEs. Retrotransposons, a class of TEs, are often located in repressed regions and are thought to induce heterochromatin formation and sp...