Estrogen-regulated PTTG1 promotes breast cancer progression by regulating cyclin kinase expression
The present study aims to investigate the effects of pituitary tumor transforming gene (PTTG) 1 on breast cancer and its underlying mechanism. GEO data set was applied to analyze the relationship between PTTG1 and survival status and the TCGA breast cancer dataset was used to explore its possible ta...
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Published in | Molecular medicine (Cambridge, Mass.) Vol. 26; no. 1; p. 33 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
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09.04.2020
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Abstract | The present study aims to investigate the effects of pituitary tumor transforming gene (PTTG) 1 on breast cancer and its underlying mechanism.
GEO data set was applied to analyze the relationship between PTTG1 and survival status and the TCGA breast cancer dataset was used to explore its possible targets. The stable cell lines including PTTG1 knockdown cells, estrogen receptor (ESR) 1 knockdown cells, and PTTG1 overexpression cells were constructed. MTT was used to determine cell viabilities. Propidium iodide (PI) staining and flow cytometry were used to analyze the cell cycle. Quantitative polymerase chain reaction (qPCR) was employed to determine the mRNA expressions. Points mutations and luciferase reporter assays were used to determine the binding sites of estrogen.
PTTG1 was associated with poor survival rates in breast cancer. In vitro study demonstrated that PTTG1 affected cell viabilities of MCF7 and T47D cells. Besides, PTTG1 affected cell cycle arrest of breast cancer cells. Overexpression of PTTG1 led to more breast cancer cells distributed in S phase. The levels of PTTG1 were associated with estrogen and further results showed that the levels of PTTG1 were positively correlated to tamoxifen resistance. Two genes including CCNA2 and CCNB2 were identified to be possible targets of PTTG1.
Estrogen-regulated PTTG1 promotes the development of breast cancer cells by the regulation of the cell cycle. |
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AbstractList | BACKGROUNDThe present study aims to investigate the effects of pituitary tumor transforming gene (PTTG) 1 on breast cancer and its underlying mechanism.METHODSGEO data set was applied to analyze the relationship between PTTG1 and survival status and the TCGA breast cancer dataset was used to explore its possible targets. The stable cell lines including PTTG1 knockdown cells, estrogen receptor (ESR) 1 knockdown cells, and PTTG1 overexpression cells were constructed. MTT was used to determine cell viabilities. Propidium iodide (PI) staining and flow cytometry were used to analyze the cell cycle. Quantitative polymerase chain reaction (qPCR) was employed to determine the mRNA expressions. Points mutations and luciferase reporter assays were used to determine the binding sites of estrogen.RESULTSPTTG1 was associated with poor survival rates in breast cancer. In vitro study demonstrated that PTTG1 affected cell viabilities of MCF7 and T47D cells. Besides, PTTG1 affected cell cycle arrest of breast cancer cells. Overexpression of PTTG1 led to more breast cancer cells distributed in S phase. The levels of PTTG1 were associated with estrogen and further results showed that the levels of PTTG1 were positively correlated to tamoxifen resistance. Two genes including CCNA2 and CCNB2 were identified to be possible targets of PTTG1.CONCLUSIONEstrogen-regulated PTTG1 promotes the development of breast cancer cells by the regulation of the cell cycle. Background The present study aims to investigate the effects of pituitary tumor transforming gene (PTTG) 1 on breast cancer and its underlying mechanism. Methods GEO data set was applied to analyze the relationship between PTTG1 and survival status and the TCGA breast cancer dataset was used to explore its possible targets. The stable cell lines including PTTG1 knockdown cells, estrogen receptor (ESR) 1 knockdown cells, and PTTG1 overexpression cells were constructed. MTT was used to determine cell viabilities. Propidium iodide (PI) staining and flow cytometry were used to analyze the cell cycle. Quantitative polymerase chain reaction (qPCR) was employed to determine the mRNA expressions. Points mutations and luciferase reporter assays were used to determine the binding sites of estrogen. Results PTTG1 was associated with poor survival rates in breast cancer. In vitro study demonstrated that PTTG1 affected cell viabilities of MCF7 and T47D cells. Besides, PTTG1 affected cell cycle arrest of breast cancer cells. Overexpression of PTTG1 led to more breast cancer cells distributed in S phase. The levels of PTTG1 were associated with estrogen and further results showed that the levels of PTTG1 were positively correlated to tamoxifen resistance. Two genes including CCNA2 and CCNB2 were identified to be possible targets of PTTG1. Conclusion Estrogen-regulated PTTG1 promotes the development of breast cancer cells by the regulation of the cell cycle. The present study aims to investigate the effects of pituitary tumor transforming gene (PTTG) 1 on breast cancer and its underlying mechanism. GEO data set was applied to analyze the relationship between PTTG1 and survival status and the TCGA breast cancer dataset was used to explore its possible targets. The stable cell lines including PTTG1 knockdown cells, estrogen receptor (ESR) 1 knockdown cells, and PTTG1 overexpression cells were constructed. MTT was used to determine cell viabilities. Propidium iodide (PI) staining and flow cytometry were used to analyze the cell cycle. Quantitative polymerase chain reaction (qPCR) was employed to determine the mRNA expressions. Points mutations and luciferase reporter assays were used to determine the binding sites of estrogen. PTTG1 was associated with poor survival rates in breast cancer. In vitro study demonstrated that PTTG1 affected cell viabilities of MCF7 and T47D cells. Besides, PTTG1 affected cell cycle arrest of breast cancer cells. Overexpression of PTTG1 led to more breast cancer cells distributed in S phase. The levels of PTTG1 were associated with estrogen and further results showed that the levels of PTTG1 were positively correlated to tamoxifen resistance. Two genes including CCNA2 and CCNB2 were identified to be possible targets of PTTG1. Estrogen-regulated PTTG1 promotes the development of breast cancer cells by the regulation of the cell cycle. Abstract Background The present study aims to investigate the effects of pituitary tumor transforming gene (PTTG) 1 on breast cancer and its underlying mechanism. Methods GEO data set was applied to analyze the relationship between PTTG1 and survival status and the TCGA breast cancer dataset was used to explore its possible targets. The stable cell lines including PTTG1 knockdown cells, estrogen receptor (ESR) 1 knockdown cells, and PTTG1 overexpression cells were constructed. MTT was used to determine cell viabilities. Propidium iodide (PI) staining and flow cytometry were used to analyze the cell cycle. Quantitative polymerase chain reaction (qPCR) was employed to determine the mRNA expressions. Points mutations and luciferase reporter assays were used to determine the binding sites of estrogen. Results PTTG1 was associated with poor survival rates in breast cancer. In vitro study demonstrated that PTTG1 affected cell viabilities of MCF7 and T47D cells. Besides, PTTG1 affected cell cycle arrest of breast cancer cells. Overexpression of PTTG1 led to more breast cancer cells distributed in S phase. The levels of PTTG1 were associated with estrogen and further results showed that the levels of PTTG1 were positively correlated to tamoxifen resistance. Two genes including CCNA2 and CCNB2 were identified to be possible targets of PTTG1 . Conclusion Estrogen-regulated PTTG1 promotes the development of breast cancer cells by the regulation of the cell cycle. Abstract Background The present study aims to investigate the effects of pituitary tumor transforming gene (PTTG) 1 on breast cancer and its underlying mechanism. Methods GEO data set was applied to analyze the relationship between PTTG1 and survival status and the TCGA breast cancer dataset was used to explore its possible targets. The stable cell lines including PTTG1 knockdown cells, estrogen receptor (ESR) 1 knockdown cells, and PTTG1 overexpression cells were constructed. MTT was used to determine cell viabilities. Propidium iodide (PI) staining and flow cytometry were used to analyze the cell cycle. Quantitative polymerase chain reaction (qPCR) was employed to determine the mRNA expressions. Points mutations and luciferase reporter assays were used to determine the binding sites of estrogen. Results PTTG1 was associated with poor survival rates in breast cancer. In vitro study demonstrated that PTTG1 affected cell viabilities of MCF7 and T47D cells. Besides, PTTG1 affected cell cycle arrest of breast cancer cells. Overexpression of PTTG1 led to more breast cancer cells distributed in S phase. The levels of PTTG1 were associated with estrogen and further results showed that the levels of PTTG1 were positively correlated to tamoxifen resistance. Two genes including CCNA2 and CCNB2 were identified to be possible targets of PTTG1. Conclusion Estrogen-regulated PTTG1 promotes the development of breast cancer cells by the regulation of the cell cycle. |
ArticleNumber | 33 |
Author | Bao, Chunhua Zou, Yan Jia, Xiaofeng Hong, Weiwei Meng, Chunhui |
Author_xml | – sequence: 1 givenname: Chunhui surname: Meng fullname: Meng, Chunhui organization: Department of General Surgery, Heze Municipal Hospital, Caozhou Road, Heze, 274000, Shandong, China – sequence: 2 givenname: Yan surname: Zou fullname: Zou, Yan organization: Department of General Surgery, Heze Municipal Hospital, Caozhou Road, Heze, 274000, Shandong, China – sequence: 3 givenname: Weiwei surname: Hong fullname: Hong, Weiwei organization: Department of General Surgery, Heze Municipal Hospital, Caozhou Road, Heze, 274000, Shandong, China – sequence: 4 givenname: Chunhua surname: Bao fullname: Bao, Chunhua organization: Department of Oncology, Heze Municipal Hospital, Caozhou Road, Heze, 274000, Shandong, China – sequence: 5 givenname: Xiaofeng surname: Jia fullname: Jia, Xiaofeng email: jiaxiaofeng198478@163.com organization: Department of Oncology, Heze Municipal Hospital, Caozhou Road, Heze, 274000, Shandong, China. jiaxiaofeng198478@163.com |
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Keywords | CCNA2 CCNB2 Breast cancer PTTG1 Estrogen |
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Snippet | The present study aims to investigate the effects of pituitary tumor transforming gene (PTTG) 1 on breast cancer and its underlying mechanism.
GEO data set was... Abstract Background The present study aims to investigate the effects of pituitary tumor transforming gene (PTTG) 1 on breast cancer and its underlying... Background The present study aims to investigate the effects of pituitary tumor transforming gene (PTTG) 1 on breast cancer and its underlying mechanism.... BACKGROUNDThe present study aims to investigate the effects of pituitary tumor transforming gene (PTTG) 1 on breast cancer and its underlying... Abstract Background The present study aims to investigate the effects of pituitary tumor transforming gene (PTTG) 1 on breast cancer and its underlying... |
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StartPage | 33 |
SubjectTerms | Binding sites Breast cancer CCNA2 CCNB2 Cell cycle Cell growth Estrogen Estrogens Flow cytometry Genes Hormone replacement therapy Kinases Metastasis Mutation Plasmids PTTG1 Tumorigenesis |
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Title | Estrogen-regulated PTTG1 promotes breast cancer progression by regulating cyclin kinase expression |
URI | https://www.ncbi.nlm.nih.gov/pubmed/32272902 https://www.proquest.com/docview/2546938301/abstract/ https://search.proquest.com/docview/2388822270 https://pubmed.ncbi.nlm.nih.gov/PMC7146910 https://doaj.org/article/416b63eab97f4c16a0272187400382f2 |
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