Magnetic resonance monitoring of focused ultrasound/magnetic nanoparticle targeting delivery of therapeutic agents to the brain

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 107; no. 34; pp. 15205 - 15210
• Main Authors: Liu, Hao-Li, Hua, Mu-Yi, Yang, Hung-Wei, Huang, Chiung-Yin, Chu, Po-Chun, Wu, Jia-Shin, Tseng, I-Chou, Wang, Jiun-Jie, Yen, Tzu-Chen, Chen, Pin-Yuan, Wei, Kuo-Chen, Weissleider, Ralph
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 24.08.2010; National Acad Sciences
• Subjects: Animals; Antibiotics, Antineoplastic - administration & dosage; Antibiotics, Antineoplastic - therapeutic use; Biological Sciences; Blood brain barrier; Brain; Brain neoplasms; Brain Neoplasms - blood supply; Brain Neoplasms - drug therapy; Brain Neoplasms - ultrastructure; Central nervous system; Chemotherapy; Contrast Media; Drug Delivery Systems - methods; drug therapy; Epirubicin - administration & dosage; Epirubicin - therapeutic use; Imaging; Macromolecules; Magnetic fields; magnetic materials; magnetic properties; Magnetic Resonance Imaging; Magnetics; Magnetism; Magnets; Medical treatment; Metal Nanoparticles - administration & dosage; Metal Nanoparticles - therapeutic use; Metal Nanoparticles - ultrastructure; Microscopy, Electron, Transmission; monitoring; N.M.R; Nanoparticles; neoplasms; NMR; Nuclear magnetic resonance; Pathology; Rats; Rats, Sprague-Dawley; Tumors; Ultrasonic Therapy; ultrasonics; Ultrasound

The superparamagnetic properties of magnetic nanoparticles (MNPs) allow them to be guided by an externally positioned magnet and also provide contrast for MRI. However, their therapeutic use in treating CNS pathologies in vivo is limited by insufficient local accumulation and retention resulting fro...