Magnetic resonance monitoring of focused ultrasound/magnetic nanoparticle targeting delivery of therapeutic agents to the brain
The superparamagnetic properties of magnetic nanoparticles (MNPs) allow them to be guided by an externally positioned magnet and also provide contrast for MRI. However, their therapeutic use in treating CNS pathologies in vivo is limited by insufficient local accumulation and retention resulting fro...
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| Published in | Proceedings of the National Academy of Sciences - PNAS Vol. 107; no. 34; pp. 15205 - 15210 |
|---|---|
| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
National Academy of Sciences
24.08.2010
National Acad Sciences |
| Subjects | |
| Online Access | Get full text |
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| Abstract | The superparamagnetic properties of magnetic nanoparticles (MNPs) allow them to be guided by an externally positioned magnet and also provide contrast for MRI. However, their therapeutic use in treating CNS pathologies in vivo is limited by insufficient local accumulation and retention resulting from their inability to traverse biological barriers. The combined use of focused ultrasound and magnetic targeting synergistically delivers therapeutic MNPs across the blood–brain barrier to enter the brain both passively and actively. Therapeutic MNPs were characterized and evaluated both in vitro and in vivo, and MRI was used to monitor and quantify their distribution in vivo. The technique could be used in normal brains or in those with tumors, and significantly increased the deposition of therapeutic MNPs in brains with intact or compromised blood–brain barriers. Synergistic targeting and image monitoring are powerful techniques for the delivery of macromolecular chemotherapeutic agents into the CNS under the guidance of MRI. |
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| AbstractList | The superparamagnetic properties of magnetic nanoparticles (MNPs) allow them to be guided by an externally positioned magnet and also provide contrast for MRI. However, their therapeutic use in treating CNS pathologies in vivo is limited by insufficient local accumulation and retention resulting from their inability to traverse biological barriers. The combined use of focused ultrasound and magnetic targeting synergistically delivers therapeutic MNPs across the blood–brain barrier to enter the brain both passively and actively. Therapeutic MNPs were characterized and evaluated both in vitro and in vivo, and MRI was used to monitor and quantify their distribution in vivo. The technique could be used in normal brains or in those with tumors, and significantly increased the deposition of therapeutic MNPs in brains with intact or compromised blood–brain barriers. Synergistic targeting and image monitoring are powerful techniques for the delivery of macromolecular chemotherapeutic agents into the CNS under the guidance of MRI. The superparamagnetic properties of magnetic nanoparticles (MNPs) allow them to be guided by an externally positioned magnet and also provide contrast for MRI. However, their therapeutic use in treating CNS pathologies in vivo is limited by insufficient local accumulation and retention resulting from their inability to traverse biological barriers. The combined use of focused ultrasound and magnetic targeting synergistically delivers therapeutic MNPs across the blood-brain barrier to enter the brain both passively and actively. Therapeutic MNPs were characterized and evaluated both in vitro and in vivo, and MRI was used to monitor and quantify their distribution in vivo. The technique could be used in normal brains or in those with tumors, and significantly increased the deposition of therapeutic MNPs in brains with intact or compromised blood-brain barriers. Synergistic targeting and image monitoring are powerful techniques for the delivery of macromolecular chemotherapeutic agents into the CNS under the guidance of MRI.The superparamagnetic properties of magnetic nanoparticles (MNPs) allow them to be guided by an externally positioned magnet and also provide contrast for MRI. However, their therapeutic use in treating CNS pathologies in vivo is limited by insufficient local accumulation and retention resulting from their inability to traverse biological barriers. The combined use of focused ultrasound and magnetic targeting synergistically delivers therapeutic MNPs across the blood-brain barrier to enter the brain both passively and actively. Therapeutic MNPs were characterized and evaluated both in vitro and in vivo, and MRI was used to monitor and quantify their distribution in vivo. The technique could be used in normal brains or in those with tumors, and significantly increased the deposition of therapeutic MNPs in brains with intact or compromised blood-brain barriers. Synergistic targeting and image monitoring are powerful techniques for the delivery of macromolecular chemotherapeutic agents into the CNS under the guidance of MRI. The superparamagnetic properties of magnetic nanoparticles (MNPs) allow them to be guided by an externally positioned magnet and also provide contrast for MRI. However, their therapeutic use in treating CNS pathologies in vivo is limited by insufficient local accumulation and retention resulting from their inability to traverse biological barriers. The combined use of focused ultrasound and magnetic targeting synergistically delivers therapeutic MNPs across the blood-brain barrier to enter the brain both passively and actively. Therapeutic MNPs were characterized and evaluated both in vitro and in vivo, and MRI was used to monitor and quantify their distribution in vivo. The technique could be used in normal brains or in those with tumors, and significantly increased the deposition of therapeutic MNPs in brains with intact or compromised blood-brain barriers. Synergistic targeting and image monitoring are powerful techniques for the delivery of macromolecular chemotherapeutic agents into the CNS under the guidance of MRI. [PUBLICATION ABSTRACT] |
| Author | Yang, Hung-Wei Wang, Jiun-Jie Yen, Tzu-Chen Tseng, I-Chou Chen, Pin-Yuan Wu, Jia-Shin Wei, Kuo-Chen Weissleider, Ralph Huang, Chiung-Yin Liu, Hao-Li Hua, Mu-Yi Chu, Po-Chun |
| Author_xml | – sequence: 1 givenname: Hao-Li surname: Liu fullname: Liu, Hao-Li – sequence: 2 givenname: Mu-Yi surname: Hua fullname: Hua, Mu-Yi – sequence: 3 givenname: Hung-Wei surname: Yang fullname: Yang, Hung-Wei – sequence: 4 givenname: Chiung-Yin surname: Huang fullname: Huang, Chiung-Yin – sequence: 5 givenname: Po-Chun surname: Chu fullname: Chu, Po-Chun – sequence: 6 givenname: Jia-Shin surname: Wu fullname: Wu, Jia-Shin – sequence: 7 givenname: I-Chou surname: Tseng fullname: Tseng, I-Chou – sequence: 8 givenname: Jiun-Jie surname: Wang fullname: Wang, Jiun-Jie – sequence: 9 givenname: Tzu-Chen surname: Yen fullname: Yen, Tzu-Chen – sequence: 10 givenname: Pin-Yuan surname: Chen fullname: Chen, Pin-Yuan – sequence: 11 givenname: Kuo-Chen surname: Wei fullname: Wei, Kuo-Chen – sequence: 12 givenname: Ralph surname: Weissleider fullname: Weissleider, Ralph |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/20696897$$D View this record in MEDLINE/PubMed |
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| Issue | 34 |
| Language | English |
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| Notes | SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 14 ObjectType-Article-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 Edited by Ralph Weissleider, Harvard Medical School, Boston, MA, and accepted by the Editorial Board July 13, 2010 (received for review March 16, 2010) 1H.-L.L., M.-Y.H., and H.-W.Y. contributed equally to this work. Author contributions: H.-L.L., M.-Y.H., H.-W.Y., P.-Y.C., and K.-C.W. designed research; H.-L.L., M.-Y.H., H.-W.Y., C.-Y.H., P.-C.C., J.-S.W., I.-C.T., J.-J.W., T.-C.Y., and P.-Y.C. performed research; H.-L.L., M.-Y.H., and H.-W.Y. contributed new reagents/analytic tools; H.-L.L., M.-Y.H., H.-W.Y., C.-Y.H., P.-C.C., J.-S.W., I.-C.T., J.-J.W., T.-C.Y., P.-Y.C., and K.-C.W. analyzed data; and H.-L.L., M.-Y.H., H.-W.Y., and K.-C.W. wrote the paper. 2P.-Y.C. and K.-C.W. contributed equally to this work. |
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| SubjectTerms | Animals Antibiotics, Antineoplastic - administration & dosage Antibiotics, Antineoplastic - therapeutic use Biological Sciences Blood brain barrier Brain Brain neoplasms Brain Neoplasms - blood supply Brain Neoplasms - drug therapy Brain Neoplasms - ultrastructure Central nervous system Chemotherapy Contrast Media Drug Delivery Systems - methods drug therapy Epirubicin - administration & dosage Epirubicin - therapeutic use Imaging Macromolecules Magnetic fields magnetic materials magnetic properties Magnetic Resonance Imaging Magnetics Magnetism Magnets Medical treatment Metal Nanoparticles - administration & dosage Metal Nanoparticles - therapeutic use Metal Nanoparticles - ultrastructure Microscopy, Electron, Transmission monitoring N.M.R Nanoparticles neoplasms NMR Nuclear magnetic resonance Pathology Rats Rats, Sprague-Dawley Tumors Ultrasonic Therapy ultrasonics Ultrasound |
| Title | Magnetic resonance monitoring of focused ultrasound/magnetic nanoparticle targeting delivery of therapeutic agents to the brain |
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