A Single Crossing-Over Event in Voltage-Sensitive Na+ Channel Genes May Cause Critical Failure of Dengue Mosquito Control by Insecticides

• Published in: PLoS neglected tropical diseases Vol. 8; no. 8; p. e3085
• Main Authors: Hirata, Koichi, Komagata, Osamu, Itokawa, Kentaro, Yamamoto, Atsushi, Tomita, Takashi, Kasai, Shinji
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 28.08.2014; Public Library of Science (PLoS)
• Subjects: Aedes - genetics; Aedes aegypti; Amino Acid Substitution - genetics; Amino acids; Animals; Biology and Life Sciences; Dengue - prevention & control; Dengue - transmission; Experiments; Female; Fever; Genes; Haplotypes; Infectious diseases; Insect control; Insecticide Resistance - genetics; Insecticides; Insects; Medicine and Health Sciences; Mosquito Control; Mosquitoes; Mutation; Sodium Channels - genetics; Studies; Tropical diseases; Xenopus; Southeast Asia

The voltage-sensitive sodium (Na+) channel (Vssc) is the target site of pyrethroid insecticides. Pest insects develop resistance to this class of insecticide by acquisition of one or multiple amino acid substitution(s) in this channel. In Southeast Asia, two major Vssc types confer pyrethroid resist...