The role of host defences in Covid 19 and treatments thereof

• Published in: Molecular medicine (Cambridge, Mass.) Vol. 26; no. 1; pp. 90 - 15
• Main Author: Dattilo, Maurizio
• Format: Journal Article
• Language: English
• Published: England BioMed Central 29.09.2020; BMC
• Subjects: Asymptomatic; Carbon monoxide; Carbon Monoxide - metabolism; Coronavirus Infections - complications; Coronavirus Infections - immunology; Coronavirus Infections - metabolism; Coronavirus Infections - therapy; COVID-19; Disease; Enzymes; Genetic Predisposition to Disease; Heme Oxygenase (Decyclizing) - metabolism; Heme oxygenase 1; Heme Oxygenase-1 - genetics; Heme Oxygenase-1 - metabolism; Homocysteine; Humans; Hydrogen sulfide; Hydrogen Sulfide - metabolism; Infections; Pandemics; Pneumonia, Viral - complications; Pneumonia, Viral - immunology; Pneumonia, Viral - metabolism; Pneumonia, Viral - therapy; Proteins; Review; Risk Factors; SARS-Cov-2; Severe acute respiratory syndrome coronavirus 2; Viral infections; Viruses; Covid 19; Hydrogen sulfide; Heme oxygenase 1; SARS-Cov-2; Carbon monoxide

Hydrogen sulfide (H 2 S) is a natural defence against the infections from enveloped RNA viruses and is likely involved also in Covid 19. It was already shown to inhibit growth and pathogenic mechanisms of a variety of enveloped RNA viruses and it was now found that circulating H 2 S is higher in Cov...