Efficient generation of transgene-free human induced pluripotent stem cells (iPSCs) by temperature-sensitive Sendai virus vectors
After the first report of induced pluripotent stem cells (iPSCs), considerable efforts have been made to develop more efficient methods for generating iPSCs without foreign gene insertions. Here we show that Sendai virus vector, an RNA virus vector that carries no risk of integrating into the host g...
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| Published in | Proceedings of the National Academy of Sciences - PNAS Vol. 108; no. 34; pp. 14234 - 14239 |
|---|---|
| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
National Academy of Sciences
23.08.2011
National Acad Sciences |
| Subjects | |
| Online Access | Get full text |
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| Abstract | After the first report of induced pluripotent stem cells (iPSCs), considerable efforts have been made to develop more efficient methods for generating iPSCs without foreign gene insertions. Here we show that Sendai virus vector, an RNA virus vector that carries no risk of integrating into the host genome, is a practical solution for the efficient generation of safer iPSCs. We improved the Sendai virus vectors by introducing temperature-sensitive mutations so that the vectors could be easily removed at nonpermissive temperatures. Using these vectors enabled the efficient production of viral/factor-free iPSCs from both human fibroblasts and CD34+ cord blood cells. Temperature-shift treatment was more effective in eliminating remaining viral vector-related genes. The resulting iPSCs expressed human embryonic stem cell markers and exhibited pluripotency. We suggest that generation of transgene-free iPSCs from cord blood cells should be an important step in providing allogeneic iPSC-derived therapy in the future. |
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| AbstractList | After the first report of induced pluripotent stem cells (iPSCs), considerable efforts have been made to develop more efficient methods for generating iPSCs without foreign gene insertions. Here we show that Sendai virus vector, an RNA virus vector that carries no risk of integrating into the host genome, is a practical solution for the efficient generation of safer iPSCs. We improved the Sendai virus vectors by introducing temperature-sensitive mutations so that the vectors could be easily removed at nonpermissive temperatures. Using these vectors enabled the efficient production of viral/factor-free iPSCs from both human fibroblasts and CD34 + cord blood cells. Temperature-shift treatment was more effective in eliminating remaining viral vector-related genes. The resulting iPSCs expressed human embryonic stem cell markers and exhibited pluripotency. We suggest that generation of transgene-free iPSCs from cord blood cells should be an important step in providing allogeneic iPSC-derived therapy in the future. After the first report of induced pluripotent stem cells (iPSCs), considerable efforts have been made to develop more efficient methods for generating iPSCs without foreign gene insertions. Here we show that Sendai virus vector, an RNA virus vector that carries no risk of integrating into the host genome, is a practical solution for the efficient generation of safer iPSCs. We improved the Sendai virus vectors by introducing temperature-sensitive mutations so that the vectors could be easily removed at nonpermissive temperatures. Using these vectors enabled the efficient production of viral/factor-free iPSCs from both human fibroblasts and CD34(+) cord blood cells. Temperature-shift treatment was more effective in eliminating remaining viral vector-related genes. The resulting iPSCs expressed human embryonic stem cell markers and exhibited pluripotency. We suggest that generation of transgene-free iPSCs from cord blood cells should be an important step in providing allogeneic iPSC-derived therapy in the future.After the first report of induced pluripotent stem cells (iPSCs), considerable efforts have been made to develop more efficient methods for generating iPSCs without foreign gene insertions. Here we show that Sendai virus vector, an RNA virus vector that carries no risk of integrating into the host genome, is a practical solution for the efficient generation of safer iPSCs. We improved the Sendai virus vectors by introducing temperature-sensitive mutations so that the vectors could be easily removed at nonpermissive temperatures. Using these vectors enabled the efficient production of viral/factor-free iPSCs from both human fibroblasts and CD34(+) cord blood cells. Temperature-shift treatment was more effective in eliminating remaining viral vector-related genes. The resulting iPSCs expressed human embryonic stem cell markers and exhibited pluripotency. We suggest that generation of transgene-free iPSCs from cord blood cells should be an important step in providing allogeneic iPSC-derived therapy in the future. After the first report of induced pluripotent stem cells (iPSCs), considerable efforts have been made to develop more efficient methods for generating iPSCs without foreign gene insertions. Here we show that Sendai virus vector, an RNA virus vector that carries no risk of integrating into the host genome, is a practical solution for the efficient generation of safer iPSCs. We improved the Sendai virus vectors by introducing temperature-sensitive mutations so that the vectors could be easily removed at nonpermissive temperatures. Using these vectors enabled the efficient production of viral/factor-free iPSCs from both human fibroblasts and CD34+ cord blood cells. Temperature-shift treatment was more effective in eliminating remaining viral vector-related genes. The resulting iPSCs expressed human embryonic stem cell markers and exhibited pluripotency. We suggest that generation of transgene-free iPSCs from cord blood cells should be an important step in providing allogeneic iPSC-derived therapy in the future. [PUBLICATION ABSTRACT] After the first report of induced pluripotent stem cells (iPSCs), considerable efforts have been made to develop more efficient methods for generating iPSCs without foreign gene insertions. Here we show that Sendai virus vector, an RNA virus vector that carries no risk of integrating into the host genome, is a practical solution for the efficient generation of safer iPSCs. We improved the Sendai virus vectors by introducing temperature-sensitive mutations so that the vectors could be easily removed at nonpermissive temperatures. Using these vectors enabled the efficient production of viral/factor-free iPSCs from both human fibroblasts and CD34 + cord blood cells. Temperature-shift treatment was more effective in eliminating remaining viral vector-related genes. The resulting iPSCs expressed human embryonic stem cell markers and exhibited pluripotency. We suggest that generation of transgene-free iPSCs from cord blood cells should be an important step in providing allogeneic iPSC-derived therapy in the future. |
| Author | Ban, Hiroshi Nishishita, Naoki Inoue, Makoto Saeki, Koichi Hasegawa, Mamoru Fusaki, Noemi Takada, Nozomi Tabata, Toshiaki Nishikawa, Shin-Ichi Kawamata, Shin Shikamura, Masayuki |
| Author_xml | – sequence: 1 givenname: Hiroshi surname: Ban fullname: Ban, Hiroshi – sequence: 2 givenname: Naoki surname: Nishishita fullname: Nishishita, Naoki – sequence: 3 givenname: Noemi surname: Fusaki fullname: Fusaki, Noemi – sequence: 4 givenname: Toshiaki surname: Tabata fullname: Tabata, Toshiaki – sequence: 5 givenname: Koichi surname: Saeki fullname: Saeki, Koichi – sequence: 6 givenname: Masayuki surname: Shikamura fullname: Shikamura, Masayuki – sequence: 7 givenname: Nozomi surname: Takada fullname: Takada, Nozomi – sequence: 8 givenname: Makoto surname: Inoue fullname: Inoue, Makoto – sequence: 9 givenname: Mamoru surname: Hasegawa fullname: Hasegawa, Mamoru – sequence: 10 givenname: Shin surname: Kawamata fullname: Kawamata, Shin – sequence: 11 givenname: Shin-Ichi surname: Nishikawa fullname: Nishikawa, Shin-Ichi |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/21821793$$D View this record in MEDLINE/PubMed |
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| Snippet | After the first report of induced pluripotent stem cells (iPSCs), considerable efforts have been made to develop more efficient methods for generating iPSCs... |
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| StartPage | 14234 |
| SubjectTerms | Animals Biological Sciences Biomarkers - metabolism Blood cells CD34 antigen Cell Differentiation Cord blood Embryo cells Embryonic Stem Cells - cytology Embryonic Stem Cells - metabolism Epigenesis, Genetic Feeder cells Fetal Blood - cytology Fibroblasts Fibroblasts - metabolism genes Genetic vectors Genetic Vectors - genetics Genomes Germ Layers - cytology Germ Layers - metabolism Hematopoietic stem cells Humans Induced pluripotent stem cells Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - metabolism Inhibitory postsynaptic potentials Insertion Mice Murine respirovirus Mutation Pluripotent stem cells Ribonucleic acid risk RNA RNA viruses Sendai virus Sendai virus - genetics Stem cells Temperature Temperature effects Transgenes - genetics Vectors Viruses |
| Title | Efficient generation of transgene-free human induced pluripotent stem cells (iPSCs) by temperature-sensitive Sendai virus vectors |
| URI | https://www.jstor.org/stable/27979490 http://www.pnas.org/content/108/34/14234.abstract https://www.ncbi.nlm.nih.gov/pubmed/21821793 https://www.proquest.com/docview/885352220 https://www.proquest.com/docview/1446266110 https://www.proquest.com/docview/885908881 https://www.proquest.com/docview/904484038 https://pubmed.ncbi.nlm.nih.gov/PMC3161531 |
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