Advances in aptamer screening and aptasensors' detection of heavy metal ions

Heavy metal pollution has become more and more serious with industrial development and resource exploitation. Because heavy metal ions are difficult to be biodegraded, they accumulate in the human body and cause serious threat to human health. However, the conventional methods to detect heavy metal...

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Published inJournal of nanobiotechnology Vol. 19; no. 1; p. 166
Main Authors Guo, Wenfei, Zhang, Chuanxiang, Ma, Tingting, Liu, Xueying, Chen, Zhu, Li, Song, Deng, Yan
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 01.06.2021
BioMed Central
BMC
Subjects
Antibodies
Aptamer
Aptamers
Aptamers, Nucleotide - isolation & purification
Aptasensor
Binding sites
Bioaccumulation
Biosensing Techniques - methods
Biosensors
Chromatography
Construction methods
Copper
Deoxyribonucleic acid
Design and construction
Detection
DNA
Environmental aspects
Environmental health
Enzymes
Exploitation
Forecasts and trends
Graphene
Health aspects
Health risks
Heavy metals
Heavy metals ion
Humans
Identification and classification
Industrial development
Ions
Ions - isolation & purification
Metal detectors
Metal ions
Metals, Heavy - isolation & purification
Methods
Molecular weight
Nucleic acid aptamers
Pollution detection
Pore size
Resource exploitation
Review
Scientific imaging
Screening
SELEX
SELEX Aptamer Technique - methods
Sensors
China
Heavy metals ion
Screening
Aptamer
Detection
Aptasensor
SELEX
Online AccessGet full text

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Abstract Heavy metal pollution has become more and more serious with industrial development and resource exploitation. Because heavy metal ions are difficult to be biodegraded, they accumulate in the human body and cause serious threat to human health. However, the conventional methods to detect heavy metal ions are more strictly to the requirements by detection equipment, sample pretreatment, experimental environment, etc. Aptasensor has the advantages of strong specificity, high sensitivity and simple preparation to detect small molecules, which provides a new direction platform in the detection of heavy metal ions. This paper reviews the selection of aptamers as target for heavy metal ions since the 21th century and aptasensors application for detection of heavy metal ions that were reported in the past five years. Firstly, the selection methods for aptamers with high specificity and high affinity are introduced. Construction methods and research progress on sensor based aptamers as recognition element are also introduced systematically. Finally, the challenges and future opportunities of aptasensors in detecting heavy metal ions are discussed.
AbstractList Heavy metal pollution has become more and more serious with industrial development and resource exploitation. Because heavy metal ions are difficult to be biodegraded, they accumulate in the human body and cause serious threat to human health. However, the conventional methods to detect heavy metal ions are more strictly to the requirements by detection equipment, sample pretreatment, experimental environment, etc. Aptasensor has the advantages of strong specificity, high sensitivity and simple preparation to detect small molecules, which provides a new direction platform in the detection of heavy metal ions. This paper reviews the selection of aptamers as target for heavy metal ions since the 21th century and aptasensors application for detection of heavy metal ions that were reported in the past five years. Firstly, the selection methods for aptamers with high specificity and high affinity are introduced. Construction methods and research progress on sensor based aptamers as recognition element are also introduced systematically. Finally, the challenges and future opportunities of aptasensors in detecting heavy metal ions are discussed.
Abstract Heavy metal pollution has become more and more serious with industrial development and resource exploitation. Because heavy metal ions are difficult to be biodegraded, they accumulate in the human body and cause serious threat to human health. However, the conventional methods to detect heavy metal ions are more strictly to the requirements by detection equipment, sample pretreatment, experimental environment, etc. Aptasensor has the advantages of strong specificity, high sensitivity and simple preparation to detect small molecules, which provides a new direction platform in the detection of heavy metal ions. This paper reviews the selection of aptamers as target for heavy metal ions since the 21th century and aptasensors application for detection of heavy metal ions that were reported in the past five years. Firstly, the selection methods for aptamers with high specificity and high affinity are introduced. Construction methods and research progress on sensor based aptamers as recognition element are also introduced systematically. Finally, the challenges and future opportunities of aptasensors in detecting heavy metal ions are discussed.
Abstract Heavy metal pollution has become more and more serious with industrial development and resource exploitation. Because heavy metal ions are difficult to be biodegraded, they accumulate in the human body and cause serious threat to human health. However, the conventional methods to detect heavy metal ions are more strictly to the requirements by detection equipment, sample pretreatment, experimental environment, etc. Aptasensor has the advantages of strong specificity, high sensitivity and simple preparation to detect small molecules, which provides a new direction platform in the detection of heavy metal ions. This paper reviews the selection of aptamers as target for heavy metal ions since the 21th century and aptasensors application for detection of heavy metal ions that were reported in the past five years. Firstly, the selection methods for aptamers with high specificity and high affinity are introduced. Construction methods and research progress on sensor based aptamers as recognition element are also introduced systematically. Finally, the challenges and future opportunities of aptasensors in detecting heavy metal ions are discussed.
Heavy metal pollution has become more and more serious with industrial development and resource exploitation. Because heavy metal ions are difficult to be biodegraded, they accumulate in the human body and cause serious threat to human health. However, the conventional methods to detect heavy metal ions are more strictly to the requirements by detection equipment, sample pretreatment, experimental environment, etc. Aptasensor has the advantages of strong specificity, high sensitivity and simple preparation to detect small molecules, which provides a new direction platform in the detection of heavy metal ions. This paper reviews the selection of aptamers as target for heavy metal ions since the 21th century and aptasensors application for detection of heavy metal ions that were reported in the past five years. Firstly, the selection methods for aptamers with high specificity and high affinity are introduced. Construction methods and research progress on sensor based aptamers as recognition element are also introduced systematically. Finally, the challenges and future opportunities of aptasensors in detecting heavy metal ions are discussed. Keywords: Aptamer, Screening, SELEX, Aptasensor, Heavy metals ion, Detection
ArticleNumber 166
Audience Academic
Author Zhang, Chuanxiang
Li, Song
Guo, Wenfei
Liu, Xueying
Deng, Yan
Chen, Zhu
Ma, Tingting
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  organization: Hunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of Technology, Zhuzhou, 412007, China
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  organization: Hunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of Technology, Zhuzhou, 412007, China
– sequence: 5
  givenname: Zhu
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  organization: Hunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of Technology, Zhuzhou, 412007, China
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  organization: Hunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of Technology, Zhuzhou, 412007, China. solisong@163.com
– sequence: 7
  givenname: Yan
  surname: Deng
  fullname: Deng, Yan
  email: hndengyan@126.com
  organization: Hunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of Technology, Zhuzhou, 412007, China. hndengyan@126.com
BackLink https://www.ncbi.nlm.nih.gov/pubmed/34074287$$D View this record in MEDLINE/PubMed
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Issue 1
Keywords Heavy metals ion
Screening
Aptamer
Detection
Aptasensor
SELEX
Language English
License Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
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Snippet Heavy metal pollution has become more and more serious with industrial development and resource exploitation. Because heavy metal ions are difficult to be...
Abstract Heavy metal pollution has become more and more serious with industrial development and resource exploitation. Because heavy metal ions are difficult...
Abstract Heavy metal pollution has become more and more serious with industrial development and resource exploitation. Because heavy metal ions are difficult...
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SubjectTerms Antibodies
Aptamer
Aptamers
Aptamers, Nucleotide - isolation & purification
Aptasensor
Binding sites
Bioaccumulation
Biosensing Techniques - methods
Biosensors
Chromatography
Construction methods
Copper
Deoxyribonucleic acid
Design and construction
Detection
DNA
Environmental aspects
Environmental health
Enzymes
Exploitation
Forecasts and trends
Graphene
Health aspects
Health risks
Heavy metals
Heavy metals ion
Humans
Identification and classification
Industrial development
Ions
Ions - isolation & purification
Metal detectors
Metal ions
Metals, Heavy - isolation & purification
Methods
Molecular weight
Nucleic acid aptamers
Pollution detection
Pore size
Resource exploitation
Review
Scientific imaging
Screening
SELEX
SELEX Aptamer Technique - methods
Sensors
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Title Advances in aptamer screening and aptasensors' detection of heavy metal ions
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