Bone-targeted erythrocyte-cancer hybrid membrane-camouflaged nanoparticles for enhancing photothermal and hypoxia-activated chemotherapy of bone invasion by OSCC

• Published in: Journal of nanobiotechnology Vol. 19; no. 1; pp. 342 - 26
• Main Authors: Chen, Hongying, Deng, Jiang, Yao, Xintong, He, Yungang, Li, Hanyue, Jian, Zhixiang, Tang, Yi, Zhang, Xiaoqing, Zhang, Jingqing, Dai, Hongwei
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 26.10.2021; BioMed Central; BMC
• Subjects: Animals; Biomimetic Materials - chemistry; Biomimetic Materials - pharmacology; Biomimetic nanoparticle; Biomimetics; Bone and Bones - metabolism; Bone cancer; Bone targeting; Bone tumors; Bones; Cancer; Cancer therapies; Cell Hypoxia - drug effects; Cell Line, Tumor; Cell Survival - drug effects; Chemotherapy; Complications; Confocal microscopy; Core-shell structure; Design and construction; Drug delivery; Drug delivery systems; Drug Delivery Systems - methods; Drug therapy; Drugs; Erythrocyte Membrane - chemistry; Erythrocyte Membrane - metabolism; Erythrocytes; Female; Flow cytometry; Fractures; Growth inhibition; Head & neck cancer; Head and neck carcinoma; Head and Neck Neoplasms - metabolism; Health aspects; Homing-targeting; Humans; Hybrid membrane; Hydroxyapatite; Hypoxia; Jaw; Ligands; Membranes; Metastasis; Mice; Mice, Nude; Microscopy; Morphology; Nanoparticles; Nanoparticles - chemistry; Oral cancer; Oral carcinoma; Oral squamous cell carcinoma; Organs; Pain; Permeability; Pharmaceutical research; Photochemotherapy - methods; Photothermal Therapy - methods; Proteins; Quality of life; Squamous cell carcinoma; Stem cells; Technology application; Theranostic Nanomedicine; Transmission electron microscopy; Tumors; Vehicles; China; Biomimetic nanoparticle; Drug delivery; Bone targeting; Homing-targeting; Hybrid membrane

Jaw bones are the most common organs to be invaded by oral malignancies, such as oral squamous cell carcinoma (OSCC), because of their special anatomical relationship. Various serious complications, such as pathological fractures and bone pain can significantly decrease the quality of life or even s...