IP-10 and MCP-1 as biomarkers associated with disease severity of COVID-19

• Published in: Molecular medicine (Cambridge, Mass.) Vol. 26; no. 1; pp. 97 - 12
• Main Authors: Chen, Yu, Wang, Jinglan, Liu, Chenxi, Su, Longxiang, Zhang, Dong, Fan, Junping, Yang, Yanli, Xiao, Meng, Xie, Jing, Xu, Yingchun, Li, Yongzhe, Zhang, Shuyang
• Format: Journal Article
• Language: English
• Published: England BioMed Central 29.10.2020; BMC
• Subjects: Adaptor Proteins, Signal Transducing - blood; Aged; Betacoronavirus - pathogenicity; Biomarkers; Biomarkers - blood; Blood platelets; Chemokine CCL2 - blood; Chemokine CXCL10 - blood; Chemokines; Coronavirus Infections - complications; Coronavirus Infections - diagnosis; Coronavirus Infections - mortality; Coronavirus Infections - virology; Coronaviruses; Correlation analysis; COVID-19; Critical Illness; Critically ill patients; Cytokine Release Syndrome - complications; Cytokine Release Syndrome - diagnosis; Cytokine Release Syndrome - mortality; Cytokine Release Syndrome - virology; Cytokines; Disease transmission; Disseminated Intravascular Coagulation - complications; Disseminated Intravascular Coagulation - diagnosis; Disseminated Intravascular Coagulation - mortality; Disseminated Intravascular Coagulation - virology; Enzymes; Female; Hospitals; Humans; Hypertension; Infections; IP-10; Male; MCP-1; Medical laboratories; Middle Aged; Pandemics; Patients; Pneumonia; Pneumonia, Viral - complications; Pneumonia, Viral - diagnosis; Pneumonia, Viral - mortality; Pneumonia, Viral - virology; Prognosis; Proteins; Pulmonary Embolism - complications; Pulmonary Embolism - diagnosis; Pulmonary Embolism - mortality; Pulmonary Embolism - virology; Respiratory Insufficiency - complications; Respiratory Insufficiency - diagnosis; Respiratory Insufficiency - mortality; Respiratory Insufficiency - virology; Retrospective Studies; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Severity of Illness Index; Statistical analysis; Survival Analysis; Thromboembolism; Thrombosis; United States > US; China; COVID-19; MCP-1; IP-10; Critically ill patients

COVID-19 is a viral respiratory disease caused by the severe acute respiratory syndrome-Coronavirus type 2 (SARS-CoV-2). Patients with this disease may be more prone to venous or arterial thrombosis because of the activation of many factors involved in it, including inflammation, platelet activation...