Association between serum 25-hydroxyvitamin D and global DNA methylation in visceral adipose tissue from colorectal cancer patients

• Published in: BMC cancer Vol. 19; no. 1; pp. 93 - 7
• Main Authors: Castellano-Castillo, Daniel, Morcillo, Sonsoles, Crujeiras, Ana B., Sánchez-Alcoholado, Lidia, Clemente-Postigo, Mercedes, Torres, Esperanza, Tinahones, Francisco José, Macias-Gonzalez, Manuel
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 21.01.2019; BioMed Central; BMC
• Subjects: Adipose tissues; Aged; Care and treatment; Colorectal cancer; Colorectal Neoplasms - blood; Colorectal Neoplasms - genetics; Development and progression; DNA Methylation; Enzyme-Linked Immunosorbent Assay; Epigenetic; Female; Global DNA methylation; Humans; Intra-Abdominal Fat - metabolism; Long Interspersed Nucleotide Elements - genetics; Male; Middle Aged; Multivariate Analysis; Obesity; Obesity - blood; Obesity - genetics; Risk factors; Sequence Analysis, DNA; Vitamin D; Vitamin D - analogs & derivatives; Vitamin D - blood; Obesity; Epigenetic; Vitamin D; Global DNA methylation; Colorectal cancer

Visceral adipose tissue (VAT) has been identified as the essential fat depot for pathogenetic theories that associateobesity and colon cancer. LINE-1 hypomethylation has been mostly detected in tumor colon tissue, but less is known about the epigenetic pattern in surrounding tissues. The aim was to...