Characterization of fosfomycin resistance and molecular epidemiology among carbapenem-resistant Klebsiella pneumoniae strains from two tertiary hospitals in China

• Published in: BMC microbiology Vol. 21; no. 1; pp. 109 - 8
• Main Authors: Wang, Haichen, Min, Changhang, Li, Jun, Yu, Ting, Hu, Yongmei, Dou, Qingya, Zou, Mingxiang
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 11.04.2021; BioMed Central; BMC
• Subjects: Amino acids; Antibiotics; Bacterial infections; Binding sites; Biosynthesis; Carbapenem resistance; Conjugation; Drug resistance in microorganisms; Drug therapy; E coli; Enzymes; Epidemiology; fosA3; Fosfomycin; Genes; Genetic aspects; Genomic analysis; Identification and classification; Infections; Klebsiella; Klebsiella infections; Klebsiella pneumoniae; Molecular modelling; Multidrug resistance; Physiological aspects; Plasmids; Statistics; Strains (organisms); China; Carbapenem resistance; fosA3; Klebsiella pneumoniae; Fosfomycin

Fosfomycin has been proven to be a vital choice to treat infection caused by multidrug resistance bacteria, especially carbapenem-resistant Klebsiella pneumoniae (CRKP). However, fosfomycin resistant cases has been reported gradually. In this study, we reported the fosfomycin-resistant rate in CRKP...