LncRNA weighted gene co-expression network analysis reveals novel biomarkers related to prostate cancer metastasis

• Published in: BMC medical genomics Vol. 15; no. 1; p. 256
• Main Authors: Liu, Miao, Chen, Man-Yun, Huang, Jia-Meng, Liu, Qian, Wang, Lin, Liu, Rong, Yang, Nian, Huang, Wei-Hua, Zhang, Wei
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 13.12.2022; BioMed Central; BMC
• Subjects: Analysis; Antigens; Biological markers; Biomarkers; Biomarkers, Tumor - genetics; Cancer therapies; Cell migration; Cluster analysis; Datasets; Development and progression; DNA microarrays; DNA probes; Gene expression; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Genetic aspects; Genomes; Humans; lncRNA; Male; Metastases; Metastasis; Neoplasm Recurrence, Local - genetics; Non-coding RNA; Prognosis; Prostate cancer; Prostatic Neoplasms - genetics; Regression analysis; Risk factors; RNA, Long Noncoding - genetics; Systems biology; Therapeutic targets; WGCNA; China; lncRNA; Metastasis; Systems biology; Prostate cancer; WGCNA

Most prostate cancer patients die from metastasis and lack accurate efficacious biomarkers to monitor the disease behavior, optimize treatment and assess prognosis. Herein, we aimed to identify meaningful lncRNA biomarkers associated with prostate cancer metastatic progression. By repurposing microa...