DNA methylation, histone acetylation and methylation of epigenetic modifications as a therapeutic approach for cancers

• Published in: Cancer letters Vol. 373; no. 2; pp. 185 - 192
• Main Authors: Yen, Ching-Yu, Huang, Hurng-Wern, Shu, Chih-Wen, Hou, Ming-Feng, Yuan, Shyng-Shiou F., Wang, Hui-Ru, Chang, Yung-Ting, Farooqi, Ammad Ahmad, Tang, Jen-Yang, Chang, Hsueh-Wei
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 10.04.2016; Elsevier Limited
• Subjects: Acetylation; Animals; Autophagy; Breast cancer; Cancer therapies; Carbohydrate Metabolism; Chromatin; DNA Methylation; Epigenesis, Genetic; Epigenetic modification; Glycolysis - drug effects; Hematology, Oncology and Palliative Medicine; Histone; Histones - metabolism; Humans; Methylation; Mutation; Neoplasms - drug therapy; Neoplasms - genetics; Neoplasms - metabolism; Neoplasms - pathology; Oxidative Stress; Sugar metabolism; Sugar metabolism; Acetylation; Methylation; Histone; Epigenetic modification

•This review summarizes the roles of epigenetic modification.•Epigenetic modification connects gene regulation, cancer, sugar metabolism, ROS, carcinogenesis, and therapeutic targets.•We discuss the combined treatment of epigenetic regulator and cancer therapy.•We highlight ongoing efforts in the ep...