Analysing the meta-interaction between pathways by gene set topological impact analysis

• Published in: BMC genomics Vol. 21; no. 1; pp. 748 - 12
• Main Authors: Yan, Shen, Chi, Xu, Chang, Xiao, Tian, Mengliang
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 27.10.2020; BioMed Central; BMC
• Subjects: Algorithm development; Algorithms; Cellular signal transduction; Computational Biology; Crosstalk; Enrichment; Functional module; Gene expression; Gene Expression Profiling; Gene Regulatory Networks; Genetic aspects; Genetic research; Genomics; Genotypes; Health aspects; Impact analysis; Influence; Methodology; Modules; Signal Transduction; Topological pathway analysis; Topology; Transcriptome; China; Functional module; Algorithm development; Topological pathway analysis

Pathway analysis is widely applied in transcriptome analysis. Given certain transcriptomic changes, current pathway analysis tools tend to search for the most impacted pathways, which provides insight into underlying biological mechanisms. Further refining of the enriched pathways and extracting fun...