Identification and functional analysis of the SARS-COV-2 nucleocapsid protein

• Published in: BMC microbiology Vol. 21; no. 1; pp. 58 - 10
• Main Authors: Gao, Tianyi, Gao, Yingdong, Liu, Xiangxiang, Nie, Zhenlin, Sun, Huilin, Lin, Kang, Peng, Hongxin, Wang, Shukui
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 22.02.2021; BioMed Central; BMC
• Subjects: Amino Acid Sequence; Amino acids; Biological properties; Cell cycle; Coils; Coronaviridae; Coronaviruses; COVID-19; COVID-19 - genetics; COVID-19 - immunology; COVID-19 - virology; Epidemics; Flow cytometry; Functional analysis; Genome, Viral - genetics; Genomes; HCT116 Cells; Heat resistance; Humans; Hydrophobicity; Identification and classification; Kinases; Localization; Mass spectrometry; Mass spectroscopy; Middle East respiratory syndrome; Molecular Sequence Data; N protein; Nucleic acids; Nucleocapsid protein (N protein); Nucleocapsid Proteins - chemistry; Nucleocapsid Proteins - genetics; Nucleocapsid Proteins - metabolism; Nucleocapsids; Phosphorylation; Physicochemical properties; Physiological aspects; Protein kinase; Protein structure; Proteins; Random coil; Reproducibility of Results; S phase; SARS-COV-2; SARS-CoV-2 - genetics; SARS-CoV-2 - metabolism; SARS-CoV-2 - pathogenicity; Severe acute respiratory syndrome coronavirus 2; Structure; Target recognition; Tertiary structure; Therapeutic targets; Vaccines; Viral diseases; Viral proteins; Viral Vaccines - therapeutic use; Viruses; China; Phosphorylation; Structure; SARS-COV-2; Nucleocapsid protein (N protein)

A severe form of pneumonia, named coronavirus disease 2019 (COVID-19) by the World Health Organization is widespread on the whole world. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was proved to be the main agent of COVID-19. In the present study, we conducted an in depth analys...