Resting-state functional MRI in depression unmasks increased connectivity between networks via the dorsal nexus

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 107; no. 24; pp. 11020 - 11025
• Main Authors: Sheline, Yvette I., Price, Joseph L., Yan, Zhizi, Mintun, Mark A., Raichle, Marcus E.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 15.06.2010; National Acad Sciences
• Subjects: A priori knowledge; Adult; Affect - physiology; Behavioral neuroscience; Biological Sciences; Brain; Case-Control Studies; cognition; Cognition - physiology; Connected regions; Connectivity; cortex; Depressive Disorder - pathology; Depressive Disorder - physiopathology; Depressive disorders; Female; Humans; Magnetic Resonance Imaging; Major depressive disorder; Male; Mental depression; Middle Aged; Models, Neurological; Mood disorders; Nerve Net - pathology; Nerve Net - physiopathology; NMR; Nuclear magnetic resonance; Physiological regulation; Prefrontal cortex; Prefrontal Cortex - pathology; Prefrontal Cortex - physiopathology; Rest - physiology; rumination

To better understand intrinsic brain connections in major depression, we used a neuroimaging technique that measures resting state functional connectivity using functional MRI (fMRI). Three different brain networks—the cognitive control network, default mode network, and affective network—were inves...