FXR activation protects against NAFLD via bile-acid-dependent reductions in lipid absorption - Clifford, Bethan L.; Sedgeman, Leslie R.; Williams, Kevin J.; Morand, Pauline; Cheng, Angela; Jarrett, Kelsey E.; Chan, Alvin P.; Brearley-Sholto, Madelaine C.; Wahlström, Annika; Ashby, Julianne W.; Barshop, William; Wohlschlegel, James; et al. (Cell metabolism, 2021)
Keywords: Animals; beta-muricholic acid; Bile; bile acids; Bile Acids and Salts - metabolism; binding; Cell Biology; cholesterol; Endocrinology & Metabolism; Endocrinology and Diabetes; Endokrinologi och diabetes; farnesoid-x-receptor; fatty liver-disease; FXR; Humans; intestinal lipid absorption; Lipids; Liver - metabolism; metabolism; Mice; Mice, Inbred C57BL; NAFLD; Non-alcoholic Fatty Liver Disease - metabolism; Non-alcoholic Fatty Liver Disease - prevention & control; nuclear receptor; Phosphatidate Phosphatase - metabolism; Receptors, Cytoplasmic and Nuclear - metabolism; small heterodimer partner; intestinal lipid absorption; FXR; NAFLD; bile acids