Face-name associative memory performance is related to amyloid burden in normal elderly

• Published in: Neuropsychologia Vol. 49; no. 9; pp. 2776 - 2783
• Main Authors: Rentz, Dorene M., Amariglio, Rebecca E., Becker, J. Alex, Frey, Meghan, Olson, Lauren E., Frishe, Katherine, Carmasin, Jeremy, Maye, Jacqueline E., Johnson, Keith A., Sperling, Reisa A.
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.07.2011; Elsevier
• Subjects: Adult and adolescent clinical studies; Aged; Aged, 80 and over; Aging; Alzheimers Disease; Amyloid beta-Peptides - metabolism; Amyloid imaging; Aniline Compounds - metabolism; Association Learning - physiology; Associative Processes; Biological and medical sciences; Brain; Cerebral Cortex - metabolism; Cognition - physiology; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Dementia; Early detection; Elderly; Face; Female; Humans; Male; Medical sciences; Memory; Memory Disorders - diagnosis; Memory Disorders - metabolism; Neurology; Normal aging; Organic mental disorders. Neuropsychology; Positron Emission Tomography; Preclinical Alzheimer's disease; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Reference Values; Retention, Psychology - physiology; Thiazoles - metabolism; Verbal Learning - physiology; Normal aging; Preclinical Alzheimer's disease; Early detection; Amyloid imaging; Human; Nervous system diseases; Senescence; Alzheimer disease; Cognition; Cerebral disorder; Associative memory; β Amyloid protein; Central nervous system disease; Medical imagery; Early; Degenerative disease; Face; Performance; Elderly; Emission tomography

Cerebral amyloid beta (Aβ) deposition occurs in a substantial fraction of cognitively normal (CN) older individuals. However, it has been difficult to reliably detect evidence of amyloid-related cognitive alterations in CN using standard neuropsychological measures. We sought to determine whether a...