MicroRNA-223 Enhances Radiation Sensitivity of U87MG Cells In Vitro and In Vivo by Targeting Ataxia Telangiectasia Mutated

• Published in: International journal of radiation oncology, biology, physics Vol. 88; no. 4; pp. 955 - 960
• Main Authors: Liang, Liping, Zhu, Ji, Zaorsky, Nicholas G., Deng, Yun, Wu, Xingzhong, Liu, Yong, Liu, Fangqi, Cai, Guoxiang, Gu, Weilie, Shen, Lijun, Zhang, Zhen
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.03.2014
• Subjects: ACTIN; Animals; Ataxia Telangiectasia Mutated Proteins - metabolism; Cell Line, Tumor; COMPARATIVE EVALUATIONS; DNA DAMAGES; Down Syndrome; Genes, Reporter; Hematology, Oncology and Palliative Medicine; Heterografts; Humans; IN VITRO; IN VIVO; IRRADIATION; KIDNEYS; Lentivirus; LUCIFERASE; Luciferases - metabolism; MESSENGER-RNA; MICE; Mice, Inbred BALB C; Mice, Nude; MicroRNAs - physiology; NEOPLASMS; PATIENTS; Radiation Tolerance - physiology; Radiology; RADIOLOGY AND NUCLEAR MEDICINE; RADIOSENSITIVITY; VIRUSES

Ataxia telangiectasia mutated (ATM) protein is important in the DNA damage response because it repairs radiation-induced damage in cancers. We examined the effect of microRNA-223 (miR-223), a regulator of ATM expression, on radiation sensitivity of cancer cells. Human embryonic kidney 293 T (293T) c...