Protection against stroke with glucagon-like peptide-1 receptor agonists: a comprehensive review of potential mechanisms

Several randomized controlled trials have demonstrated the benefits of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on ischemic stroke in patients with diabetes. In this review, we summarize and discuss the potential mechanisms of stroke protection by GLP-1RAs. GLP-1RAs exert multiple anti-a...

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Published inCardiovascular diabetology Vol. 21; no. 1; pp. 242 - 11
Main Authors Vergès, Bruno, Aboyans, Victor, Angoulvant, Denis, Boutouyrie, Pierre, Cariou, Bertrand, Hyafil, Fabien, Mohammedi, Kamel, Amarenco, Pierre
Format Journal Article
LanguageEnglish
Published England BioMed Central 15.11.2022
BMC
Subjects
Agonists
Angiogenesis
Animal models
Animals
Apoptosis
Arteriosclerosis
Blood pressure
Blood-brain barrier
Brain
Cardiology and cardiovascular system
Clinical trials
Cognitive science
Diabetes
Diabetes mellitus
Diabetes Mellitus, Type 2 - chemically induced
Dyslipidemia
Excitotoxicity
GLP-1
Glucagon
Glucagon-like peptide 1
Glucagon-Like Peptide-1 Receptor - agonists
Glucose
Heart failure
Human health and pathology
Humans
Hyperglycemia
Hyperglycemia - chemically induced
Hypoglycemic Agents - adverse effects
Inflammation
Insulin resistance
Ischemia
Life Sciences
Lipoproteins
Mechanisms
Membrane permeability
Metabolism
Neural plasticity
Neurogenesis
Neuroprotection
Neuroscience
Nitric oxide
Oxidative stress
Peptides
Pharmaceutical sciences
Pharmacokinetics
Pharmacology
Review
Risk factors
Smooth muscle
Stroke
Stroke - chemically induced
Stroke - prevention & control
Neuroprotection
Mechanisms
Stroke
GLP-1
Glucagon-like peptide-1 receptor agonists
Hypoglycemic Agents
Hyperglycemia
Animals
Glucagon-Like Peptide-1 Receptor
Humans
Type 2
Diabetes Mellitus
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Abstract Several randomized controlled trials have demonstrated the benefits of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on ischemic stroke in patients with diabetes. In this review, we summarize and discuss the potential mechanisms of stroke protection by GLP-1RAs. GLP-1RAs exert multiple anti-atherosclerotic effects contributing to stroke prevention such as enhanced plaque stability, reduced vascular smooth muscle proliferation, increased nitric oxide, and improved endothelial function. GLP-1RAs also lower the risk of stroke by reducing traditional stroke risk factors including hyperglycemia, hypertension, and dyslipidemia. Independently of these peripheral actions, GLP-1RAs show direct cerebral effects in animal stroke models, such as reduction of infarct volume, apoptosis, oxidative stress, neuroinflammation, excitotoxicity, blood-brain barrier permeability, and increased neurogenesis, neuroplasticity, angiogenesis, and brain perfusion. Despite these encouraging findings, further research is still needed to understand more thoroughly the mechanisms by which GLP-1RAs may mediate stroke protection specifically in the human diabetic brain.
AbstractList Several randomized controlled trials have demonstrated the benefits of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on ischemic stroke in patients with diabetes. In this review, we summarize and discuss the potential mechanisms of stroke protection by GLP-1RAs. GLP-1RAs exert multiple anti-atherosclerotic effects contributing to stroke prevention such as enhanced plaque stability, reduced vascular smooth muscle proliferation, increased nitric oxide, and improved endothelial function. GLP-1RAs also lower the risk of stroke by reducing traditional stroke risk factors including hyperglycemia, hypertension, and dyslipidemia. Independently of these peripheral actions, GLP-1RAs show direct cerebral effects in animal stroke models, such as reduction of infarct volume, apoptosis, oxidative stress, neuroinflammation, excitotoxicity, blood-brain barrier permeability, and increased neurogenesis, neuroplasticity, angiogenesis, and brain perfusion. Despite these encouraging findings, further research is still needed to understand more thoroughly the mechanisms by which GLP-1RAs may mediate stroke protection specifically in the human diabetic brain.
Abstract Several randomized controlled trials have demonstrated the benefits of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on ischemic stroke in patients with diabetes. In this review, we summarize and discuss the potential mechanisms of stroke protection by GLP-1RAs. GLP-1RAs exert multiple anti-atherosclerotic effects contributing to stroke prevention such as enhanced plaque stability, reduced vascular smooth muscle proliferation, increased nitric oxide, and improved endothelial function. GLP-1RAs also lower the risk of stroke by reducing traditional stroke risk factors including hyperglycemia, hypertension, and dyslipidemia. Independently of these peripheral actions, GLP-1RAs show direct cerebral effects in animal stroke models, such as reduction of infarct volume, apoptosis, oxidative stress, neuroinflammation, excitotoxicity, blood–brain barrier permeability, and increased neurogenesis, neuroplasticity, angiogenesis, and brain perfusion. Despite these encouraging findings, further research is still needed to understand more thoroughly the mechanisms by which GLP-1RAs may mediate stroke protection specifically in the human diabetic brain.
Abstract Several randomized controlled trials have demonstrated the benefits of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on ischemic stroke in patients with diabetes. In this review, we summarize and discuss the potential mechanisms of stroke protection by GLP-1RAs. GLP-1RAs exert multiple anti-atherosclerotic effects contributing to stroke prevention such as enhanced plaque stability, reduced vascular smooth muscle proliferation, increased nitric oxide, and improved endothelial function. GLP-1RAs also lower the risk of stroke by reducing traditional stroke risk factors including hyperglycemia, hypertension, and dyslipidemia. Independently of these peripheral actions, GLP-1RAs show direct cerebral effects in animal stroke models, such as reduction of infarct volume, apoptosis, oxidative stress, neuroinflammation, excitotoxicity, blood–brain barrier permeability, and increased neurogenesis, neuroplasticity, angiogenesis, and brain perfusion. Despite these encouraging findings, further research is still needed to understand more thoroughly the mechanisms by which GLP-1RAs may mediate stroke protection specifically in the human diabetic brain.
ArticleNumber 242
Author Amarenco, Pierre
Cariou, Bertrand
Hyafil, Fabien
Mohammedi, Kamel
Angoulvant, Denis
Vergès, Bruno
Aboyans, Victor
Boutouyrie, Pierre
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  givenname: Bruno
  surname: Vergès
  fullname: Vergès, Bruno
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  organization: Department of Endocrinology, Diabetes and Metabolic Disorders, Dijon University Hospital, INSERM Unit, LNC-UMR 1231, University of Burgundy, Dijon, France. bruno.verges@chu-dijon.fr
– sequence: 2
  givenname: Victor
  surname: Aboyans
  fullname: Aboyans, Victor
  organization: Department of Cardiology, EpiMaCT - INSERM UMR, Dupuytren University Hospital, Limoges University, 1094 & IRD 270, Limoges, France
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  givenname: Denis
  surname: Angoulvant
  fullname: Angoulvant, Denis
  organization: EA4245 Transplantation, Immunity & Inflammation, Department of Cardiology, University of Tours, Tours University Hospital, Tours, France
– sequence: 4
  givenname: Pierre
  surname: Boutouyrie
  fullname: Boutouyrie, Pierre
  organization: Paris Cardiovascular Research CenterUMR-970Department of Pharmacology, INSERM, Georges-Pompidou European Hospital, Paris City University, Paris, France
– sequence: 5
  givenname: Bertrand
  surname: Cariou
  fullname: Cariou, Bertrand
  organization: University of Nantes, Nantes University Hospital Centre, CNRS, INSERM, L'institut du Thorax, Nantes, France
– sequence: 6
  givenname: Fabien
  surname: Hyafil
  fullname: Hyafil, Fabien
  organization: Department of Nuclear Medicine, DMU IMAGINA, Georges-Pompidou European Hospital, APHP, Paris City University, Paris, France
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  givenname: Kamel
  surname: Mohammedi
  fullname: Mohammedi, Kamel
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– sequence: 8
  givenname: Pierre
  surname: Amarenco
  fullname: Amarenco, Pierre
  organization: Neurology and Stroke Center, SOS-TIA Clinic, Bichat Hospital, University of Paris, Paris, France
BackLink https://www.ncbi.nlm.nih.gov/pubmed/36380358$$D View this record in MEDLINE/PubMed
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Issue 1
Keywords Neuroprotection
Mechanisms
Stroke
GLP-1
Glucagon-like peptide-1 receptor agonists
Hypoglycemic Agents
Hyperglycemia
Animals
Glucagon-Like Peptide-1 Receptor
Humans
Type 2
Diabetes Mellitus
Language English
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Snippet Several randomized controlled trials have demonstrated the benefits of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on ischemic stroke in patients with...
Abstract Several randomized controlled trials have demonstrated the benefits of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on ischemic stroke in...
Abstract Several randomized controlled trials have demonstrated the benefits of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on ischemic stroke in...
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SubjectTerms Agonists
Angiogenesis
Animal models
Animals
Apoptosis
Arteriosclerosis
Blood pressure
Blood-brain barrier
Brain
Cardiology and cardiovascular system
Clinical trials
Cognitive science
Diabetes
Diabetes mellitus
Diabetes Mellitus, Type 2 - chemically induced
Dyslipidemia
Excitotoxicity
GLP-1
Glucagon
Glucagon-like peptide 1
Glucagon-Like Peptide-1 Receptor - agonists
Glucose
Heart failure
Human health and pathology
Humans
Hyperglycemia
Hyperglycemia - chemically induced
Hypoglycemic Agents - adverse effects
Inflammation
Insulin resistance
Ischemia
Life Sciences
Lipoproteins
Mechanisms
Membrane permeability
Metabolism
Neural plasticity
Neurogenesis
Neuroprotection
Neuroscience
Nitric oxide
Oxidative stress
Peptides
Pharmaceutical sciences
Pharmacokinetics
Pharmacology
Review
Risk factors
Smooth muscle
Stroke
Stroke - chemically induced
Stroke - prevention & control
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Title Protection against stroke with glucagon-like peptide-1 receptor agonists: a comprehensive review of potential mechanisms
URI https://www.ncbi.nlm.nih.gov/pubmed/36380358
https://www.proquest.com/docview/2737654787
https://hal.science/hal-04013171
https://pubmed.ncbi.nlm.nih.gov/PMC9667639
https://doaj.org/article/e759114c1ecc42259c34da9c8d8a1e54
Volume 21
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