Hollow polydopamine nanoparticles loading with peptide RL-QN15: a new pro-regenerative therapeutic agent for skin wounds

• Published in: Journal of nanobiotechnology Vol. 19; no. 1; pp. 304 - 20
• Main Authors: Sun, Huiling, Wang, Ying, He, Tiantian, He, Dingwei, Hu, Yan, Fu, Zhe, Wang, Yinglei, Sun, Dandan, Wang, Junsong, Liu, Yixiang, Shu, Longjun, He, Li, Deng, Ziwei, Yang, Xinwang
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 02.10.2021; BioMed Central; BMC
• Subjects: Animal models; Animals; Biocompatibility; Biopolymers; Care and treatment; Cell Survival - drug effects; Chemical compounds; Cytokines; Dermatologic agents; Dermatologic Agents - chemistry; Dermatologic Agents - pharmacology; Dermatologic Agents - toxicity; Dermatology; Disease Models, Animal; Drug development; Drugs; Enzymes; Epidermal growth factor; Formulae, receipts, prescriptions; Fourier transforms; HaCaT Cells; Health aspects; Hollow polydopamine; Humans; Indoles - chemistry; Indoles - toxicity; Keratinocytes; Macrophages; Male; Materials; Mice; Mice, Nude; Morphology; Nanomaterials; Nanoparticles; Nanoparticles - chemistry; Nanoparticles - toxicity; Nanotechnology; Peptides; Peptides - chemistry; Peptides - pharmacology; Peptides - toxicity; Permeability; Pharmacology; Physiology; Polymers - chemistry; Polymers - toxicity; Pro-regenerative agent; Production processes; Rats; Rats, Sprague-Dawley; RAW 264.7 Cells; Regenerative medicine; RL-QN15; Scald; Skin; Skin - drug effects; Skin - injuries; Spectrum analysis; Swine; Thickness; Tissue engineering; Toxicity; Tumor necrosis factor-TNF; Ulcers; Wound healing; Wound Healing - drug effects; Wounds and injuries; China; Nanoparticles; Pro-regenerative agent; Hollow polydopamine; Wound healing; RL-QN15

Although the treatments of skin wounds have greatly improved with the increase in therapeutic methods and agents, available interventions still cannot meet the current clinical needs. Therefore, the development of new pro-regenerative therapies remains urgent. Owing to their unique characteristics,...