Hollow polydopamine nanoparticles loading with peptide RL-QN15: a new pro-regenerative therapeutic agent for skin wounds
Although the treatments of skin wounds have greatly improved with the increase in therapeutic methods and agents, available interventions still cannot meet the current clinical needs. Therefore, the development of new pro-regenerative therapies remains urgent. Owing to their unique characteristics,...
Saved in:
| Published in | Journal of nanobiotechnology Vol. 19; no. 1; pp. 304 - 20 |
|---|---|
| Main Authors | , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
BioMed Central Ltd
02.10.2021
BioMed Central BMC |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Although the treatments of skin wounds have greatly improved with the increase in therapeutic methods and agents, available interventions still cannot meet the current clinical needs. Therefore, the development of new pro-regenerative therapies remains urgent. Owing to their unique characteristics, both nanomaterials and peptides have provided novel clues for the development of pro-regenerative agents, however, more efforts were still be awaited and anticipated.
In the current research, Hollow polydopamine (HPDA) nanoparticles were synthesized and HPDA nanoparticles loading with RL-QN15 (HPDAlR) that was an amphibian-derived peptide with obvious prohealing activities were prepared successfully. The characterization, biodistribution and clearance of both HPDA nanoparticles and HPDAlR were evaluated, the loading efficiency of HPDA against RL-QN15 and the slow-releasing rate of RL-QN15 from HPDAlR were also determined. Our results showed that both HPDA nanoparticles and HPDAlR exerted no obvious toxicity against keratinocyte, macrophage and mice, and HPDA nanoparticles showed no prohealing potency in vivo and in vitro. Interestingly, HPDAlR significantly enhanced the ability of RL-QN15 to accelerate the healing of scratch of keratinocytes and selectively modulate the release of healing-involved cytokines from macrophages. More importantly, in comparison with RL-QN15, by evaluating on animal models of full-thickness injured skin wounds in mice and oral ulcers in rats, HPDAlR showed significant increasing in the pro-regenerative potency of 50 and 10 times, respectively. Moreover, HPDAlR also enhanced the prohealing efficiency of peptide RL-QN15 against skin scald in mice and full-thickness injured wounds in swine.
HPDA obviously enhanced the pro-regenerative potency of RL-QN15 in vitro and in vivo, hence HPDAlR exhibited great potential in the development of therapeutics for skin wound healing. |
|---|---|
| AbstractList | Although the treatments of skin wounds have greatly improved with the increase in therapeutic methods and agents, available interventions still cannot meet the current clinical needs. Therefore, the development of new pro-regenerative therapies remains urgent. Owing to their unique characteristics, both nanomaterials and peptides have provided novel clues for the development of pro-regenerative agents, however, more efforts were still be awaited and anticipated. In the current research, Hollow polydopamine (HPDA) nanoparticles were synthesized and HPDA nanoparticles loading with RL-QN15 (HPDAlR) that was an amphibian-derived peptide with obvious prohealing activities were prepared successfully. The characterization, biodistribution and clearance of both HPDA nanoparticles and HPDAlR were evaluated, the loading efficiency of HPDA against RL-QN15 and the slow-releasing rate of RL-QN15 from HPDAlR were also determined. Our results showed that both HPDA nanoparticles and HPDAlR exerted no obvious toxicity against keratinocyte, macrophage and mice, and HPDA nanoparticles showed no prohealing potency in vivo and in vitro. Interestingly, HPDAlR significantly enhanced the ability of RL-QN15 to accelerate the healing of scratch of keratinocytes and selectively modulate the release of healing-involved cytokines from macrophages. More importantly, in comparison with RL-QN15, by evaluating on animal models of full-thickness injured skin wounds in mice and oral ulcers in rats, HPDAlR showed significant increasing in the pro-regenerative potency of 50 and 10 times, respectively. Moreover, HPDAlR also enhanced the prohealing efficiency of peptide RL-QN15 against skin scald in mice and full-thickness injured wounds in swine. HPDA obviously enhanced the pro-regenerative potency of RL-QN15 in vitro and in vivo, hence HPDAlR exhibited great potential in the development of therapeutics for skin wound healing. Background Although the treatments of skin wounds have greatly improved with the increase in therapeutic methods and agents, available interventions still cannot meet the current clinical needs. Therefore, the development of new pro-regenerative therapies remains urgent. Owing to their unique characteristics, both nanomaterials and peptides have provided novel clues for the development of pro-regenerative agents, however, more efforts were still be awaited and anticipated. Results In the current research, Hollow polydopamine (HPDA) nanoparticles were synthesized and HPDA nanoparticles loading with RL-QN15 (HPDAlR) that was an amphibian-derived peptide with obvious prohealing activities were prepared successfully. The characterization, biodistribution and clearance of both HPDA nanoparticles and HPDAlR were evaluated, the loading efficiency of HPDA against RL-QN15 and the slow-releasing rate of RL-QN15 from HPDAlR were also determined. Our results showed that both HPDA nanoparticles and HPDAlR exerted no obvious toxicity against keratinocyte, macrophage and mice, and HPDA nanoparticles showed no prohealing potency in vivo and in vitro. Interestingly, HPDAlR significantly enhanced the ability of RL-QN15 to accelerate the healing of scratch of keratinocytes and selectively modulate the release of healing-involved cytokines from macrophages. More importantly, in comparison with RL-QN15, by evaluating on animal models of full-thickness injured skin wounds in mice and oral ulcers in rats, HPDAlR showed significant increasing in the pro-regenerative potency of 50 and 10 times, respectively. Moreover, HPDAlR also enhanced the prohealing efficiency of peptide RL-QN15 against skin scald in mice and full-thickness injured wounds in swine. Conclusions HPDA obviously enhanced the pro-regenerative potency of RL-QN15 in vitro and in vivo, hence HPDAlR exhibited great potential in the development of therapeutics for skin wound healing. Graphic Keywords: Hollow polydopamine, Nanoparticles, RL-QN15, Wound healing, Pro-regenerative agent Background Although the treatments of skin wounds have greatly improved with the increase in therapeutic methods and agents, available interventions still cannot meet the current clinical needs. Therefore, the development of new pro-regenerative therapies remains urgent. Owing to their unique characteristics, both nanomaterials and peptides have provided novel clues for the development of pro-regenerative agents, however, more efforts were still be awaited and anticipated. Results In the current research, Hollow polydopamine (HPDA) nanoparticles were synthesized and HPDA nanoparticles loading with RL-QN15 (HPDAlR) that was an amphibian-derived peptide with obvious prohealing activities were prepared successfully. The characterization, biodistribution and clearance of both HPDA nanoparticles and HPDAlR were evaluated, the loading efficiency of HPDA against RL-QN15 and the slow-releasing rate of RL-QN15 from HPDAlR were also determined. Our results showed that both HPDA nanoparticles and HPDAlR exerted no obvious toxicity against keratinocyte, macrophage and mice, and HPDA nanoparticles showed no prohealing potency in vivo and in vitro. Interestingly, HPDAlR significantly enhanced the ability of RL-QN15 to accelerate the healing of scratch of keratinocytes and selectively modulate the release of healing-involved cytokines from macrophages. More importantly, in comparison with RL-QN15, by evaluating on animal models of full-thickness injured skin wounds in mice and oral ulcers in rats, HPDAlR showed significant increasing in the pro-regenerative potency of 50 and 10 times, respectively. Moreover, HPDAlR also enhanced the prohealing efficiency of peptide RL-QN15 against skin scald in mice and full-thickness injured wounds in swine. Conclusions HPDA obviously enhanced the pro-regenerative potency of RL-QN15 in vitro and in vivo, hence HPDAlR exhibited great potential in the development of therapeutics for skin wound healing. Graphic Abstract Although the treatments of skin wounds have greatly improved with the increase in therapeutic methods and agents, available interventions still cannot meet the current clinical needs. Therefore, the development of new pro-regenerative therapies remains urgent. Owing to their unique characteristics, both nanomaterials and peptides have provided novel clues for the development of pro-regenerative agents, however, more efforts were still be awaited and anticipated. In the current research, Hollow polydopamine (HPDA) nanoparticles were synthesized and HPDA nanoparticles loading with RL-QN15 (HPDAlR) that was an amphibian-derived peptide with obvious prohealing activities were prepared successfully. The characterization, biodistribution and clearance of both HPDA nanoparticles and HPDAlR were evaluated, the loading efficiency of HPDA against RL-QN15 and the slow-releasing rate of RL-QN15 from HPDAlR were also determined. Our results showed that both HPDA nanoparticles and HPDAlR exerted no obvious toxicity against keratinocyte, macrophage and mice, and HPDA nanoparticles showed no prohealing potency in vivo and in vitro. Interestingly, HPDAlR significantly enhanced the ability of RL-QN15 to accelerate the healing of scratch of keratinocytes and selectively modulate the release of healing-involved cytokines from macrophages. More importantly, in comparison with RL-QN15, by evaluating on animal models of full-thickness injured skin wounds in mice and oral ulcers in rats, HPDAlR showed significant increasing in the pro-regenerative potency of 50 and 10 times, respectively. Moreover, HPDAlR also enhanced the prohealing efficiency of peptide RL-QN15 against skin scald in mice and full-thickness injured wounds in swine. HPDA obviously enhanced the pro-regenerative potency of RL-QN15 in vitro and in vivo, hence HPDAlR exhibited great potential in the development of therapeutics for skin wound healing. Abstract Background Although the treatments of skin wounds have greatly improved with the increase in therapeutic methods and agents, available interventions still cannot meet the current clinical needs. Therefore, the development of new pro-regenerative therapies remains urgent. Owing to their unique characteristics, both nanomaterials and peptides have provided novel clues for the development of pro-regenerative agents, however, more efforts were still be awaited and anticipated. Results In the current research, Hollow polydopamine (HPDA) nanoparticles were synthesized and HPDA nanoparticles loading with RL-QN15 (HPDAlR) that was an amphibian-derived peptide with obvious prohealing activities were prepared successfully. The characterization, biodistribution and clearance of both HPDA nanoparticles and HPDAlR were evaluated, the loading efficiency of HPDA against RL-QN15 and the slow-releasing rate of RL-QN15 from HPDAlR were also determined. Our results showed that both HPDA nanoparticles and HPDAlR exerted no obvious toxicity against keratinocyte, macrophage and mice, and HPDA nanoparticles showed no prohealing potency in vivo and in vitro. Interestingly, HPDAlR significantly enhanced the ability of RL-QN15 to accelerate the healing of scratch of keratinocytes and selectively modulate the release of healing-involved cytokines from macrophages. More importantly, in comparison with RL-QN15, by evaluating on animal models of full-thickness injured skin wounds in mice and oral ulcers in rats, HPDAlR showed significant increasing in the pro-regenerative potency of 50 and 10 times, respectively. Moreover, HPDAlR also enhanced the prohealing efficiency of peptide RL-QN15 against skin scald in mice and full-thickness injured wounds in swine. Conclusions HPDA obviously enhanced the pro-regenerative potency of RL-QN15 in vitro and in vivo, hence HPDAlR exhibited great potential in the development of therapeutics for skin wound healing. Graphic Abstract Although the treatments of skin wounds have greatly improved with the increase in therapeutic methods and agents, available interventions still cannot meet the current clinical needs. Therefore, the development of new pro-regenerative therapies remains urgent. Owing to their unique characteristics, both nanomaterials and peptides have provided novel clues for the development of pro-regenerative agents, however, more efforts were still be awaited and anticipated.BACKGROUNDAlthough the treatments of skin wounds have greatly improved with the increase in therapeutic methods and agents, available interventions still cannot meet the current clinical needs. Therefore, the development of new pro-regenerative therapies remains urgent. Owing to their unique characteristics, both nanomaterials and peptides have provided novel clues for the development of pro-regenerative agents, however, more efforts were still be awaited and anticipated.In the current research, Hollow polydopamine (HPDA) nanoparticles were synthesized and HPDA nanoparticles loading with RL-QN15 (HPDAlR) that was an amphibian-derived peptide with obvious prohealing activities were prepared successfully. The characterization, biodistribution and clearance of both HPDA nanoparticles and HPDAlR were evaluated, the loading efficiency of HPDA against RL-QN15 and the slow-releasing rate of RL-QN15 from HPDAlR were also determined. Our results showed that both HPDA nanoparticles and HPDAlR exerted no obvious toxicity against keratinocyte, macrophage and mice, and HPDA nanoparticles showed no prohealing potency in vivo and in vitro. Interestingly, HPDAlR significantly enhanced the ability of RL-QN15 to accelerate the healing of scratch of keratinocytes and selectively modulate the release of healing-involved cytokines from macrophages. More importantly, in comparison with RL-QN15, by evaluating on animal models of full-thickness injured skin wounds in mice and oral ulcers in rats, HPDAlR showed significant increasing in the pro-regenerative potency of 50 and 10 times, respectively. Moreover, HPDAlR also enhanced the prohealing efficiency of peptide RL-QN15 against skin scald in mice and full-thickness injured wounds in swine.RESULTSIn the current research, Hollow polydopamine (HPDA) nanoparticles were synthesized and HPDA nanoparticles loading with RL-QN15 (HPDAlR) that was an amphibian-derived peptide with obvious prohealing activities were prepared successfully. The characterization, biodistribution and clearance of both HPDA nanoparticles and HPDAlR were evaluated, the loading efficiency of HPDA against RL-QN15 and the slow-releasing rate of RL-QN15 from HPDAlR were also determined. Our results showed that both HPDA nanoparticles and HPDAlR exerted no obvious toxicity against keratinocyte, macrophage and mice, and HPDA nanoparticles showed no prohealing potency in vivo and in vitro. Interestingly, HPDAlR significantly enhanced the ability of RL-QN15 to accelerate the healing of scratch of keratinocytes and selectively modulate the release of healing-involved cytokines from macrophages. More importantly, in comparison with RL-QN15, by evaluating on animal models of full-thickness injured skin wounds in mice and oral ulcers in rats, HPDAlR showed significant increasing in the pro-regenerative potency of 50 and 10 times, respectively. Moreover, HPDAlR also enhanced the prohealing efficiency of peptide RL-QN15 against skin scald in mice and full-thickness injured wounds in swine.HPDA obviously enhanced the pro-regenerative potency of RL-QN15 in vitro and in vivo, hence HPDAlR exhibited great potential in the development of therapeutics for skin wound healing.CONCLUSIONSHPDA obviously enhanced the pro-regenerative potency of RL-QN15 in vitro and in vivo, hence HPDAlR exhibited great potential in the development of therapeutics for skin wound healing. |
| ArticleNumber | 304 |
| Audience | Academic |
| Author | Fu, Zhe Sun, Huiling Hu, Yan Yang, Xinwang Wang, Ying Wang, Junsong Liu, Yixiang He, Dingwei He, Tiantian Sun, Dandan He, Li Shu, Longjun Deng, Ziwei Wang, Yinglei |
| Author_xml | – sequence: 1 givenname: Huiling surname: Sun fullname: Sun, Huiling – sequence: 2 givenname: Ying surname: Wang fullname: Wang, Ying – sequence: 3 givenname: Tiantian surname: He fullname: He, Tiantian – sequence: 4 givenname: Dingwei surname: He fullname: He, Dingwei – sequence: 5 givenname: Yan surname: Hu fullname: Hu, Yan – sequence: 6 givenname: Zhe surname: Fu fullname: Fu, Zhe – sequence: 7 givenname: Yinglei surname: Wang fullname: Wang, Yinglei – sequence: 8 givenname: Dandan surname: Sun fullname: Sun, Dandan – sequence: 9 givenname: Junsong surname: Wang fullname: Wang, Junsong – sequence: 10 givenname: Yixiang surname: Liu fullname: Liu, Yixiang – sequence: 11 givenname: Longjun surname: Shu fullname: Shu, Longjun – sequence: 12 givenname: Li surname: He fullname: He, Li – sequence: 13 givenname: Ziwei surname: Deng fullname: Deng, Ziwei – sequence: 14 givenname: Xinwang orcidid: 0000-0003-3210-8908 surname: Yang fullname: Yang, Xinwang |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34600530$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kktv1DAUhSNURB_wB1ggS2xgkeJn7LBAqiqgI41AFFhbjmNnPGTs1E467b_H0xlKp0IosnJ1_Z1j3atzXBz44E1RvETwFCFRvUsI1wyVEOeDIK1L_KQ4QpTzkiDGDh7Uh8VxSksIMaaYPisOCa0gZAQeFTcXoe_DGgyhv23DoFbOG-CVz2Ucne5NAn1QrfMdWLtxAQYzjK414HJefvuC2HuggDdZHkMZTWe8iWp01waMi1wNZsoeQOX-CGyIIP1yHqzD5Nv0vHhqVZ_Mi93_pPj56eOP84ty_vXz7PxsXmpW87FkVmCNkEZEE1tTZCrKNEWq5Q2vtLUtxxBxYeuKYawFbmphSaNwQxQT3ApyUsy2vm1QSzlEt1LxVgbl5F0jxE7uJpXMUgp13pHGnDYMNVoZjFDTMC1M3bLs9WHrNUzNyrQ6jxVVv2e6f-PdQnbhWgoqOCMkG7zZGcRwNZk0ypVL2vS98iZMSWLGayhqijdvvX6ELsMUfV5VpgSBQvCa_KU6lQdw3ob8rt6YyrOKC4gQhVWmTv9B5a81K6dzqKzL_T3B2z1BZkZzM3ZqSknOvl_us68eLuV-G38ylgG8BXQMKUVj7xEE5SbIchtkmYMs74IscRaJRyLtxhytsFms6_8n_Q1emfXO |
| CitedBy_id | crossref_primary_10_1016_j_biopha_2024_116184 crossref_primary_10_1016_j_biopha_2024_116168 crossref_primary_10_1093_burnst_tkac032 crossref_primary_10_1021_acsami_2c03583 crossref_primary_10_1021_acsami_2c19790 crossref_primary_10_3389_fbioe_2023_1250533 crossref_primary_10_1016_j_cej_2024_158387 crossref_primary_10_1038_s41467_024_54081_9 crossref_primary_10_1016_j_bbrc_2022_02_017 crossref_primary_10_1186_s12974_022_02647_z crossref_primary_10_1007_s00726_023_03341_x crossref_primary_10_1021_acsomega_4c06268 crossref_primary_10_3390_ijms24119689 crossref_primary_10_1016_j_nantod_2024_102151 crossref_primary_10_1039_D4RA01352B crossref_primary_10_1016_j_porgcoat_2025_109112 crossref_primary_10_1021_acsami_3c16061 crossref_primary_10_1208_s12249_024_02827_5 crossref_primary_10_1016_j_ejphar_2024_177233 crossref_primary_10_1093_burnst_tkad035 crossref_primary_10_1016_j_expneurol_2022_114180 crossref_primary_10_1002_adfm_202300681 crossref_primary_10_1016_j_biopha_2022_112987 crossref_primary_10_1002_tox_23914 crossref_primary_10_2174_1570159X21666230502111013 crossref_primary_10_1096_fj_202201798RR crossref_primary_10_1002_adfm_202302225 crossref_primary_10_1021_acs_jafc_2c00354 crossref_primary_10_4103_1673_5374_369119 crossref_primary_10_1016_j_bioadv_2024_213937 crossref_primary_10_1016_j_smaim_2022_11_005 crossref_primary_10_1016_j_ijbiomac_2025_141785 crossref_primary_10_1016_j_matdes_2022_111085 crossref_primary_10_1038_s41427_022_00444_x crossref_primary_10_3389_fphar_2023_1120228 |
| Cites_doi | 10.1259/bjr.20150207 10.1016/j.jfda.2016.09.007 10.1016/j.msec.2019.110174 10.1016/j.copbio.2013.02.020 10.4155/tde-2016-0031 10.1021/am3027025 10.12688/f1000research.18293.1 10.1186/s13287-019-1203-3 10.1016/j.jcis.2017.10.102 10.1016/j.addr.2017.08.001 10.1159/000088478 10.1039/C4TB00460D 10.1016/j.sjbs.2019.02.005 10.1021/acs.chemrev.5b00731 10.1039/c1cs15103g 10.1002/adma.201800939 10.1155/2019/4513108 10.1016/j.colsurfb.2020.110820 10.1002/adhm.201600150 10.1021/acs.accounts.6b00480 10.1021/acs.jafc.8b05879 10.2217/nnm-2019-0401 10.1016/j.biopha.2019.109535 10.1021/acsnano.8b01152 10.1021/jacs.7b11114 10.1080/14786419.2020.1856840 10.1038/s41598-018-19486-9 10.1080/21691401.2018.1561457 10.1208/s12249-019-1325-z 10.1055/s-0030-1255354 10.1016/j.addr.2019.01.005 10.1016/j.jconrel.2011.03.021 10.1615/CritRevTherDrugCarrierSyst.2013006955 10.1016/j.ijpharm.2012.03.056 10.1039/C8NR09818B 10.1016/j.biomaterials.2011.03.050 10.1186/s12951-020-00624-3 10.3390/md18050233 10.1111/cbdd.13063 10.1016/j.jvs.2018.01.065 10.1159/000495320 10.1002/lary.25649 10.7150/thno.14431 10.1021/acsami.6b00291 10.2147/IJN.S132780 10.1016/j.ymthe.2017.09.023 10.1016/j.biopha.2016.09.010 10.1186/s12951-019-0514-y 10.1016/j.trsl.2019.11.002 10.2174/0929867325666181031122438 10.1016/j.phrs.2020.105296 10.1039/C9TB01397K 10.1002/jps.23725 10.1021/acssuschemeng.0c06672 10.1016/j.pestbp.2020.104696 10.24272/j.issn.2095-8137.2020.358 10.1002/adhm.201700344 10.1186/1476-511X-9-74 10.1016/j.addr.2018.03.007 10.1007/PL00007448 |
| ContentType | Journal Article |
| Copyright | 2021. The Author(s). COPYRIGHT 2021 BioMed Central Ltd. 2021. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. The Author(s) 2021 |
| Copyright_xml | – notice: 2021. The Author(s). – notice: COPYRIGHT 2021 BioMed Central Ltd. – notice: 2021. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: The Author(s) 2021 |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM ISR 3V. 7QO 7TB 7X7 7XB 88E 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABJCF ABUWG AFKRA AZQEC BBNVY BENPR BGLVJ BHPHI CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ HCIFZ K9. KB. LK8 M0S M1P M7P P64 PDBOC PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS 7X8 5PM DOA |
| DOI | 10.1186/s12951-021-01049-2 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Gale In Context: Science ProQuest Central (Corporate) Biotechnology Research Abstracts Mechanical & Transportation Engineering Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Materials Science & Engineering Collection ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials ProQuest : Biological Science Collection journals [unlimited simultaneous users] ProQuest Central Technology Collection Natural Science Collection ProQuest One Community College ProQuest Materials Science Collection ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Materials Science Database Biological Sciences ProQuest Health & Medical Collection Medical Database Biological Science Database Biotechnology and BioEngineering Abstracts Materials Science Collection ProQuest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Publicly Available Content Database ProQuest Central Student Technology Collection Technology Research Database ProQuest One Academic Middle East (New) Mechanical & Transportation Engineering Abstracts ProQuest Central Essentials Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Central China ProQuest Central ProQuest One Applied & Life Sciences ProQuest Health & Medical Research Collection Health Research Premium Collection Biotechnology Research Abstracts Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Health & Medical Research Collection Biological Science Collection Materials Science Database ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Materials Science Collection ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition Materials Science & Engineering Collection Engineering Research Database ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | Publicly Available Content Database MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 4 dbid: 8FG name: ProQuest Technology Collection url: https://search.proquest.com/technologycollection1 sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Engineering |
| EISSN | 1477-3155 |
| EndPage | 20 |
| ExternalDocumentID | oai_doaj_org_article_5f440c224c274b51bcae211bb5c8e9d5 PMC8487533 A678011406 34600530 10_1186_s12951_021_01049_2 |
| Genre | Journal Article |
| GeographicLocations | China |
| GeographicLocations_xml | – name: China |
| GrantInformation_xml | – fundername: Program for Innovative Research Team in Ministry of Education of China grantid: IRT17-R49 – fundername: Natural Science Basic Research Plan in Shannxi province of China grantid: No.2021JM-202 – fundername: Yunnan Applied Basic Research Project Foundation grantid: 2019FB128 – fundername: National Natural Science Foundation of China grantid: 32060212 – fundername: National Natural Science Foundation of China grantid: 81760648 – fundername: ; grantid: 81760648; 32060212 – fundername: ; grantid: IRT17-R49 – fundername: ; grantid: 2019FB128 – fundername: ; grantid: No.2021JM-202 |
| GroupedDBID | --- 0R~ 29L 2WC 53G 5VS 7X7 88E 8FE 8FG 8FH 8FI 8FJ AAFWJ AAJSJ AASML AAYXX ABDBF ABJCF ABUWG ACGFO ACGFS ACIHN ACIWK ACPRK ACUHS ADBBV ADDVE ADMLS ADRAZ ADUKV AEAQA AENEX AFKRA AFPKN AFRAH AHBYD AHMBA AHYZX ALIPV ALMA_UNASSIGNED_HOLDINGS AMKLP AMTXH AOIJS BAPOH BAWUL BBNVY BCNDV BENPR BFQNJ BGLVJ BHPHI BMC BPHCQ BVXVI C6C CCPQU CITATION CS3 D1I DIK DU5 E3Z EBD EBLON EBS EMOBN ESX F5P FYUFA GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE I-F IAO IHR INH INR ISR ITC ITG ITH KB. KQ8 LK8 M1P M48 M7P MM. M~E O5R O5S OK1 OVT P2P PDBOC PGMZT PHGZM PHGZT PIMPY PQQKQ PROAC PSQYO RBZ RNS ROL RPM RSV RVI SCM SOJ SV3 TR2 TUS UKHRP WOQ WOW XSB ~8M CGR CUY CVF ECM EIF NPM PMFND 3V. 7QO 7TB 7XB 8FD 8FK AZQEC DWQXO FR3 GNUQQ K9. P64 PJZUB PKEHL PPXIY PQEST PQGLB PQUKI PRINS 7X8 5PM PUEGO |
| ID | FETCH-LOGICAL-c597t-5f82c11c13c3f941e645c41ad7b76cffd720178f96522c82b98f3ba2b3a587f83 |
| IEDL.DBID | M48 |
| ISSN | 1477-3155 |
| IngestDate | Wed Aug 27 01:29:59 EDT 2025 Thu Aug 21 14:07:30 EDT 2025 Fri Jul 11 00:00:42 EDT 2025 Fri Jul 25 19:21:35 EDT 2025 Tue Jun 17 21:11:05 EDT 2025 Tue Jun 10 20:37:32 EDT 2025 Fri Jun 27 05:09:01 EDT 2025 Thu Apr 03 07:00:33 EDT 2025 Thu Apr 24 23:10:59 EDT 2025 Tue Jul 01 01:26:47 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | Nanoparticles Pro-regenerative agent Hollow polydopamine Wound healing RL-QN15 |
| Language | English |
| License | 2021. The Author(s). Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c597t-5f82c11c13c3f941e645c41ad7b76cffd720178f96522c82b98f3ba2b3a587f83 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| ORCID | 0000-0003-3210-8908 |
| OpenAccessLink | http://journals.scholarsportal.info/openUrl.xqy?doi=10.1186/s12951-021-01049-2 |
| PMID | 34600530 |
| PQID | 2583088793 |
| PQPubID | 44676 |
| PageCount | 20 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_5f440c224c274b51bcae211bb5c8e9d5 pubmedcentral_primary_oai_pubmedcentral_nih_gov_8487533 proquest_miscellaneous_2579089425 proquest_journals_2583088793 gale_infotracmisc_A678011406 gale_infotracacademiconefile_A678011406 gale_incontextgauss_ISR_A678011406 pubmed_primary_34600530 crossref_primary_10_1186_s12951_021_01049_2 crossref_citationtrail_10_1186_s12951_021_01049_2 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2021-10-02 |
| PublicationDateYYYYMMDD | 2021-10-02 |
| PublicationDate_xml | – month: 10 year: 2021 text: 2021-10-02 day: 02 |
| PublicationDecade | 2020 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England – name: London |
| PublicationTitle | Journal of nanobiotechnology |
| PublicationTitleAlternate | J Nanobiotechnology |
| PublicationYear | 2021 |
| Publisher | BioMed Central Ltd BioMed Central BMC |
| Publisher_xml | – name: BioMed Central Ltd – name: BioMed Central – name: BMC |
| References | M Miao (1049_CR52) 2019; 26 Y Xi (1049_CR37) 2018; 12 SR Park (1049_CR6) 2018; 26 X Cao (1049_CR26) 2018; 8 J Hu (1049_CR38) 2011; 40 SC Baetke (1049_CR31) 2015; 88 D Park (1049_CR47) 2016; 5 X Li (1049_CR3) 2018; 91 SM Dadfar (1049_CR32) 2019; 138 SM Karppinen (1049_CR48) 2019; 8 JH Lee (1049_CR7) 2013; 102 L Dong (1049_CR19) 2019; 7 B Mi (1049_CR5) 2020; 18 W Wang (1049_CR11) 2019; 17 L Yu (1049_CR39) 2017; 50 X Wang (1049_CR16) 2016; 116 M Sattary (1049_CR56) 2020; 170 S Huang (1049_CR59) 2020; 12 S Easmin (1049_CR45) 2017; 25 L Yu (1049_CR18) 2018; 30 LY Rizzo (1049_CR33) 2013; 24 MA Mofazzal Jahromi (1049_CR35) 2018; 123 B Mi (1049_CR22) 2018; 51 AK Jain (1049_CR14) 2019; 47 S Sachdeva (1049_CR29) 2016; 7 R Dimatteo (1049_CR12) 2018; 127 Y Wang (1049_CR17) 2018; 513 S Shen (1049_CR30) 2017; 12 M Parani (1049_CR36) 2016; 8 N Liu (1049_CR21) 2019; 67 B Shang (1049_CR15) 2020; 106 HL Xu (1049_CR10) 2017; 6 S Yin (1049_CR24) 2019; 120 MR Rekha (1049_CR20) 2013; 440 A Shpichka (1049_CR51) 2019; 10 A Jain (1049_CR44) 2013; 30 Y Wang (1049_CR27) 2021; 163 YR Ma (1049_CR46) 2013; 5 N Lian (1049_CR8) 2016; 84 X Deng (1049_CR1) 2021; 9 TA Wynn (1049_CR50) 2010; 30 L Ouyang (1049_CR13) 2019; 18 X Yang (1049_CR43) 2019; 26 KV Raghavan (1049_CR42) 2010; 9 R Vinaik (1049_CR4) 2020; 217 Z Deng (1049_CR41) 2011; 32 Z Dong (1049_CR57) 2016; 6 J Bai (1049_CR58) 2018; 140 Y Zhang (1049_CR25) 2021; 42 JM Davidson (1049_CR54) 1998; 290 Y Xie (1049_CR9) 2011; 153 SJ Cao (1049_CR28) 2019; 20 S Wang (1049_CR23) 2020; 1 D Singh (1049_CR34) 2020; 15 T Yan (1049_CR2) 2020; 18 Y Liu (1049_CR60) 2020; 189 Y Zhang (1049_CR55) 2019; 11 P Carmeliet (1049_CR49) 2005; 69 YS Lim (1049_CR53) 2016; 126 RF Irons (1049_CR62) 2018; 68 Y Cong (1049_CR40) 2014; 2 S Dinescu (1049_CR61) 2019; 2019 |
| References_xml | – volume: 88 start-page: 20150207 year: 2015 ident: 1049_CR31 publication-title: Br J Radiol doi: 10.1259/bjr.20150207 – volume: 25 start-page: 306 year: 2017 ident: 1049_CR45 publication-title: J Food Drug Anal doi: 10.1016/j.jfda.2016.09.007 – volume: 106 start-page: 110174 year: 2020 ident: 1049_CR15 publication-title: Mater Sci Eng C Mater Biol Appl doi: 10.1016/j.msec.2019.110174 – volume: 24 start-page: 1159 year: 2013 ident: 1049_CR33 publication-title: Curr Opin Biotechnol doi: 10.1016/j.copbio.2013.02.020 – volume: 7 start-page: 355 year: 2016 ident: 1049_CR29 publication-title: Ther Deliv doi: 10.4155/tde-2016-0031 – volume: 5 start-page: 1024 year: 2013 ident: 1049_CR46 publication-title: ACS Appl Mater Interfaces doi: 10.1021/am3027025 – volume: 8 start-page: 1 year: 2019 ident: 1049_CR48 publication-title: F1000 Res doi: 10.12688/f1000research.18293.1 – volume: 10 start-page: 94 year: 2019 ident: 1049_CR51 publication-title: Stem Cell Res Ther doi: 10.1186/s13287-019-1203-3 – volume: 513 start-page: 43 year: 2018 ident: 1049_CR17 publication-title: J Colloid Interface Sci doi: 10.1016/j.jcis.2017.10.102 – volume: 123 start-page: 33 year: 2018 ident: 1049_CR35 publication-title: Adv Drug Deliv Rev doi: 10.1016/j.addr.2017.08.001 – volume: 69 start-page: 4 year: 2005 ident: 1049_CR49 publication-title: Oncology doi: 10.1159/000088478 – volume: 2 start-page: 3450 year: 2014 ident: 1049_CR40 publication-title: J Mater Chem B doi: 10.1039/C4TB00460D – volume: 26 start-page: 790 year: 2019 ident: 1049_CR52 publication-title: Saudi J Biol Sci doi: 10.1016/j.sjbs.2019.02.005 – volume: 116 start-page: 10983 year: 2016 ident: 1049_CR16 publication-title: Chem Rev doi: 10.1021/acs.chemrev.5b00731 – volume: 40 start-page: 5472 year: 2011 ident: 1049_CR38 publication-title: Chem Soc Rev doi: 10.1039/c1cs15103g – volume: 30 start-page: e1800939 year: 2018 ident: 1049_CR18 publication-title: Adv Mater doi: 10.1002/adma.201800939 – volume: 2019 start-page: 4513108 year: 2019 ident: 1049_CR61 publication-title: J Immunol Res doi: 10.1155/2019/4513108 – volume: 189 start-page: 110820 year: 2020 ident: 1049_CR60 publication-title: Colloids Surf B Biointerfaces doi: 10.1016/j.colsurfb.2020.110820 – volume: 5 start-page: 2019 year: 2016 ident: 1049_CR47 publication-title: Adv Healthc Mater doi: 10.1002/adhm.201600150 – volume: 50 start-page: 293 year: 2017 ident: 1049_CR39 publication-title: Acc Chem Res doi: 10.1021/acs.accounts.6b00480 – volume: 67 start-page: 220 year: 2019 ident: 1049_CR21 publication-title: J Agric Food Chem doi: 10.1021/acs.jafc.8b05879 – volume: 15 start-page: 111 year: 2020 ident: 1049_CR34 publication-title: Nanomedicine (Lond) doi: 10.2217/nnm-2019-0401 – volume: 120 start-page: 109535 year: 2019 ident: 1049_CR24 publication-title: Biomed Pharmacother doi: 10.1016/j.biopha.2019.109535 – volume: 12 start-page: 10772 year: 2018 ident: 1049_CR37 publication-title: ACS Nano doi: 10.1021/acsnano.8b01152 – volume: 140 start-page: 106 year: 2018 ident: 1049_CR58 publication-title: J Am Chem Soc doi: 10.1021/jacs.7b11114 – volume: 1 start-page: 1 year: 2020 ident: 1049_CR23 publication-title: Nat Prod Res doi: 10.1080/14786419.2020.1856840 – volume: 8 start-page: 943 year: 2018 ident: 1049_CR26 publication-title: Sci Rep doi: 10.1038/s41598-018-19486-9 – volume: 47 start-page: 524 year: 2019 ident: 1049_CR14 publication-title: Artif Cells Nanomed Biotechnol doi: 10.1080/21691401.2018.1561457 – volume: 20 start-page: 190 year: 2019 ident: 1049_CR28 publication-title: AAPS Pharm Sci Tech doi: 10.1208/s12249-019-1325-z – volume: 30 start-page: 245 year: 2010 ident: 1049_CR50 publication-title: Semin Liver Dis doi: 10.1055/s-0030-1255354 – volume: 138 start-page: 302 year: 2019 ident: 1049_CR32 publication-title: Adv Drug Deliv Rev doi: 10.1016/j.addr.2019.01.005 – volume: 153 start-page: 225 year: 2011 ident: 1049_CR9 publication-title: J Control Release doi: 10.1016/j.jconrel.2011.03.021 – volume: 18 start-page: 2933 year: 2019 ident: 1049_CR13 publication-title: Exp Ther Med – volume: 30 start-page: 293 year: 2013 ident: 1049_CR44 publication-title: Crit Rev Ther Drug Carrier Syst doi: 10.1615/CritRevTherDrugCarrierSyst.2013006955 – volume: 440 start-page: 48 year: 2013 ident: 1049_CR20 publication-title: Int J Pharm doi: 10.1016/j.ijpharm.2012.03.056 – volume: 11 start-page: 6315 year: 2019 ident: 1049_CR55 publication-title: Nanoscale doi: 10.1039/C8NR09818B – volume: 32 start-page: 4976 year: 2011 ident: 1049_CR41 publication-title: Biomaterials doi: 10.1016/j.biomaterials.2011.03.050 – volume: 18 start-page: 68 year: 2020 ident: 1049_CR5 publication-title: J Nanobiotechnol doi: 10.1186/s12951-020-00624-3 – volume: 18 start-page: 1 year: 2020 ident: 1049_CR2 publication-title: Mar Drugs doi: 10.3390/md18050233 – volume: 12 start-page: 28952 year: 2020 ident: 1049_CR59 publication-title: ACS Appl Mater Interfaces – volume: 91 start-page: 126 year: 2018 ident: 1049_CR3 publication-title: Chem Biol Drug Des doi: 10.1111/cbdd.13063 – volume: 68 start-page: 115S year: 2018 ident: 1049_CR62 publication-title: J Vasc Surg doi: 10.1016/j.jvs.2018.01.065 – volume: 51 start-page: 647 year: 2018 ident: 1049_CR22 publication-title: Cell Physiol Biochem doi: 10.1159/000495320 – volume: 126 start-page: E68 year: 2016 ident: 1049_CR53 publication-title: Laryngoscope doi: 10.1002/lary.25649 – volume: 6 start-page: 1031 year: 2016 ident: 1049_CR57 publication-title: Theranostics doi: 10.7150/thno.14431 – volume: 8 start-page: 10049 year: 2016 ident: 1049_CR36 publication-title: ACS Appl Mater Interfaces doi: 10.1021/acsami.6b00291 – volume: 12 start-page: 4085 year: 2017 ident: 1049_CR30 publication-title: Int J Nanomedicine doi: 10.2147/IJN.S132780 – volume: 26 start-page: 606 year: 2018 ident: 1049_CR6 publication-title: Mol Ther doi: 10.1016/j.ymthe.2017.09.023 – volume: 84 start-page: 42 year: 2016 ident: 1049_CR8 publication-title: Biomed Pharmacother doi: 10.1016/j.biopha.2016.09.010 – volume: 17 start-page: 82 year: 2019 ident: 1049_CR11 publication-title: J Nanobiotechnol doi: 10.1186/s12951-019-0514-y – volume: 217 start-page: 47 year: 2020 ident: 1049_CR4 publication-title: Transl Res doi: 10.1016/j.trsl.2019.11.002 – volume: 26 start-page: 4749 year: 2019 ident: 1049_CR43 publication-title: Curr Med Chem doi: 10.2174/0929867325666181031122438 – volume: 163 start-page: 105296 year: 2021 ident: 1049_CR27 publication-title: Pharmacol Res doi: 10.1016/j.phrs.2020.105296 – volume: 7 start-page: 6172 year: 2019 ident: 1049_CR19 publication-title: J Mater Chem B doi: 10.1039/C9TB01397K – volume: 102 start-page: 4109 year: 2013 ident: 1049_CR7 publication-title: J Pharm Sci doi: 10.1002/jps.23725 – volume: 9 start-page: 3070 year: 2021 ident: 1049_CR1 publication-title: ACS Sustain Chem Eng doi: 10.1021/acssuschemeng.0c06672 – volume: 170 start-page: 104696 year: 2020 ident: 1049_CR56 publication-title: Pestic Biochem Physiol doi: 10.1016/j.pestbp.2020.104696 – volume: 42 start-page: 141 year: 2021 ident: 1049_CR25 publication-title: Zool Res doi: 10.24272/j.issn.2095-8137.2020.358 – volume: 6 start-page: 1 year: 2017 ident: 1049_CR10 publication-title: Adv Healthc Mater doi: 10.1002/adhm.201700344 – volume: 9 start-page: 74 year: 2010 ident: 1049_CR42 publication-title: Lipids Health Dis doi: 10.1186/1476-511X-9-74 – volume: 127 start-page: 167 year: 2018 ident: 1049_CR12 publication-title: Adv Drug Deliv Rev doi: 10.1016/j.addr.2018.03.007 – volume: 290 start-page: S1 issue: Suppl year: 1998 ident: 1049_CR54 publication-title: Arch Dermatol Res doi: 10.1007/PL00007448 |
| SSID | ssj0022424 |
| Score | 2.4544628 |
| Snippet | Although the treatments of skin wounds have greatly improved with the increase in therapeutic methods and agents, available interventions still cannot meet the... Background Although the treatments of skin wounds have greatly improved with the increase in therapeutic methods and agents, available interventions still... Abstract Background Although the treatments of skin wounds have greatly improved with the increase in therapeutic methods and agents, available interventions... |
| SourceID | doaj pubmedcentral proquest gale pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | 304 |
| SubjectTerms | Animal models Animals Biocompatibility Biopolymers Care and treatment Cell Survival - drug effects Chemical compounds Cytokines Dermatologic agents Dermatologic Agents - chemistry Dermatologic Agents - pharmacology Dermatologic Agents - toxicity Dermatology Disease Models, Animal Drug development Drugs Enzymes Epidermal growth factor Formulae, receipts, prescriptions Fourier transforms HaCaT Cells Health aspects Hollow polydopamine Humans Indoles - chemistry Indoles - toxicity Keratinocytes Macrophages Male Materials Mice Mice, Nude Morphology Nanomaterials Nanoparticles Nanoparticles - chemistry Nanoparticles - toxicity Nanotechnology Peptides Peptides - chemistry Peptides - pharmacology Peptides - toxicity Permeability Pharmacology Physiology Polymers - chemistry Polymers - toxicity Pro-regenerative agent Production processes Rats Rats, Sprague-Dawley RAW 264.7 Cells Regenerative medicine RL-QN15 Scald Skin Skin - drug effects Skin - injuries Spectrum analysis Swine Thickness Tissue engineering Toxicity Tumor necrosis factor-TNF Ulcers Wound healing Wound Healing - drug effects Wounds and injuries |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3fi9QwEA5yT_og_rZ6ShTBBwnXpkma-naKxyp64OnBvYUkTc7DtV2uu5z-986k3aVF0BffSjOFdmYyM9_uzBdCXui8dlDmW8Ytt0zEyjKAYIrxqKPVVtWC43Dyp2O1OBUfzuTZ5Kgv7Akb6IEHxR3IKETuIdF4wE9OFs7bAKDFOel1qJvEXgo5bwumRqiFQw_bERmtDnrIahJgM0foDDUx47M0lNj6_4zJk6Q0b5icZKCjW-TmWDrSw-GVb5Nrob1DbkwIBe-Snwswa3dFV93yVwNw-Acs0da2cDk2wNFll7rmKf4AS1fY09IEevKRfT4u5GtqKZTZFF6NXYbzxEiN4ZBOprSoxWEsCrUu7b9ftPQKz2Xq75HTo3df3y7YeLYC8wAh1kxGzX1R-KL0ZaxFEZSQXhS2qVylfIxNBZVBpWOtoEDzmrtax9JZ7kordRV1eZ_stV0bHhKquAhNI6F0bLQQvnEA6RyYQDqASzGvMlJsVW38SDyO518sTQIgWpnBPAbMY5J5DM_Iq90zq4F246_Sb9CCO0mkzE43wJHMqF_zL0fKyHO0v0FSjBa7bs7tpu_N-y8n5hAyOgLHXGXk5SgUO_gGb8chBtAE8mjNJPdnkrBr_Xx562ZmjBq94VKXGPXrMiPPdsv4JHbCtaHboEyFf9VCqM3Ig8Erd99dCoVBNc9INfPXmWLmK-3Ft8QprhNwLR_9D00-Jtc5bjVss-D7ZG99uQlPoHRbu6dpl_4GfXs_hA priority: 102 providerName: Directory of Open Access Journals – databaseName: Health & Medical Collection dbid: 7X7 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3fb9MwELZgvMAD4vcCAxmExAOy1ji24_CCBmIqCCYxmNQ3y3bsMlGS0rQa_PfcpW7XCGlvUXyREt_5fJ9z9x0hL_WochDmW8Ytt0zE0jKAYIrxqKPVVlWCY3HylxM1PhOfJnKSDty6lFa58Ym9o65bj2fkh1zqAldEVbyd_2bYNQr_rqYWGtfJDaQuw5SucnIJuLD0YVMoo9VhB3ubBPDMEUBDZMz4YDPqOfv_98w7W9MwbXJnHzq-Q26nAJIerTV-l1wLzT1ya4dW8D75Mwblthd03s7-1gCKf8EQbWwDlykNjs7aPnee4jEsnWNmSx3o6Wf29SSXb6ilEGxTeDW2CNOelxqdIt2p1aIWS7IoRLy0-3ne0AvsztQ9IGfHH76_H7PUYYF5ABJLJqPmPs99XvgiViIPSkgvcluXrlQ-xrqE-KDUsVIQpnnNXaVj4Sx3hZW6jLp4SPaatgn7hCouQl1LCCBrLYSvHQA7ByqQDkBTHJUZyTdTbXyiH8cuGDPTwxCtzFo9BtRjevUYnpHX22fma_KNK6XfoQa3kkic3d9oF1OT5tfIKMTIg2V4gONO5s7bABjYOel1qGqZkReof4PUGA3m3kztquvMx2-n5gj2dYSPI5WRV0kotvAN3qZSBpgJZNMaSB4MJGHt-uHwxsxM8h2dubT0jDzfDuOTmA_XhHaFMiX-sAWHm5FHa6vcfnchFLrWUUbKgb0OJmY40pz_6JnFdQ9fi8dXv9YTcpPjIsI0Cn5A9paLVXgKodnSPevX3z_nHTbJ priority: 102 providerName: ProQuest |
| Title | Hollow polydopamine nanoparticles loading with peptide RL-QN15: a new pro-regenerative therapeutic agent for skin wounds |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/34600530 https://www.proquest.com/docview/2583088793 https://www.proquest.com/docview/2579089425 https://pubmed.ncbi.nlm.nih.gov/PMC8487533 https://doaj.org/article/5f440c224c274b51bcae211bb5c8e9d5 |
| Volume | 19 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3db9MwELfG9gIPiG8CozIIiQcUaBw7dpAQ2tBKQayCQqW-WbYTl4mSlH5o23_PnZtWjZgQL1VUX6LY9_lz7s6EPFfd3EKYb2JmmIm5lyYGCJbFzCtvlMlyzrA4-XSQ9Uf801iM98jmuKNmARdXQjs8T2o0n766-H35DhT-bVB4lb1egM8SAIoZAmOIeGMwyQfgmSQq6infflVgWAoRqo0k7s0JsSmiufIZLUcV-vn_bbV33FY7pXLHR_VukZtNcEmP1tJwm-yV1R1yY6fl4F1y0QfG1-d0Vk8vCwDMv2CIVqaCyyZFjk7rkFdPcYuWzjDrpSjp8HP8dZCIN9RQCMQpvFo8LyehZzUaTLpTx0UNlmtRiIbp4udZRc_x5KbFPTLqnXx_34-b0xdiByBjGQuvmEsSl6Qu9TlPyowLxxNTSCsz530hIXaQyucZhHBOMZsrn1rDbGqEkl6l98l-VVflQ0IzxsuiEBBcFopzV1gAfRbYISwAKt-VEUk2S61d05ocT8iY6gBRVKbX7NHAHh3Yo1lEXm7vma0bc_yT-hg5uKXEptrhj3o-0c36auE57zqQEgdQ3YrEOlMCPrZWOFXmhYjIM-S_xrYZFeblTMxqsdAfvw31Efh8hJbdLCIvGiJfwxycacocYCWw01aL8rBFCXrt2sMbMdMbtdBMqBT9Qp5G5Ol2GO_EXLmqrFdII_FjLhjjiDxYS-V23inP0Ox2IyJb8tpamPZIdfYjdB1XAdqmj_57fo_JdYb6hNkW7JDsL-er8glEcEvbIdfkWMKv6n3okIPjk8GXYSfshnSCwv4BmlZEJQ |
| linkProvider | Scholars Portal |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1bb9MwFLbGeAAeEHcCAwwC8YCiJY6dOEgIjcvUsq4SY5P6ZmwnLhMlKU2rsj_Fb-ScNOkaIe1tb1F8EiU-1y85F0JeyiA1EOZrn2mmfe4S7QMEi33mpNNSxylnWJx8OIx7J_zLSIy2yN-2FgbTKlubWBvqrLT4jXyXCRmhRqTR--lvH6dG4d_VdoTGSiwO8rMlQLbqXf8T8PcVY_ufjz_2_GaqgG8heJ77wklmw9CGkY1cysM85sLyUGeJSWLrXJYwHFnv0hhCEyuZSaWLjGYm0kImTkZw3yvkKjjeADUqGZ0DPCy1aAtzZLxbgS8VANYZAnaIxH3WcX71jID_PcGGK-ymaW74vf1b5GYTsNK9lYTdJlt5cYfc2GhjeJf86YEwlUs6LSdnGYDwX7BEC13AYZN2RydlnatP8bMvnWImTZbTo4H_dRiKt1RTCO4pPJo_y8d1H2w0wnSjNoxqLAGjEGHT6udpQZc4Daq6R04uZe_vk-2iLPKHhMaM51kmIGDNJOc2MwAkDbBAGABpLkg8ErZbrWzT7hynbkxUDXtkrFbsUcAeVbNHMY-8WV8zXTX7uJD6A3JwTYmNuusT5Wysmv1VwnEeWJAMC_DfiNBYnQPmNkZYmaeZ8MgL5L_CVhwF5vqM9aKqVP_bkdqDOALhahB75HVD5Ep4B6ub0gnYCeze1aHc6VCCrbDd5VbMVGOrKnWuWR55vl7GKzH_rsjLBdIk-IMYDLxHHqykcv3eEY_RlAceSTry2tmY7kpx-qPuZC5ruBw9uvixnpFrvePDgRr0hwePyXWGCoUpHGyHbM9ni_wJhIVz87TWRUq-X7by_wN66HM0 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Hollow+polydopamine+nanoparticles+loading+with+peptide+RL-QN15%3A+a+new+pro-regenerative+therapeutic+agent+for+skin+wounds&rft.jtitle=Journal+of+nanobiotechnology&rft.au=Sun%2C+Huiling&rft.au=Wang%2C+Ying&rft.au=He%2C+Tiantian&rft.au=He%2C+Dingwei&rft.date=2021-10-02&rft.pub=BioMed+Central+Ltd&rft.issn=1477-3155&rft.eissn=1477-3155&rft.volume=19&rft.issue=1&rft_id=info:doi/10.1186%2Fs12951-021-01049-2&rft.externalDocID=A678011406 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1477-3155&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1477-3155&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1477-3155&client=summon |