Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease

• Published in: Cellular and molecular life sciences : CMLS Vol. 75; no. 18; pp. 3313 - 3327
• Main Authors: Ipsen, David Højland, Lykkesfeldt, Jens, Tveden-Nyborg, Pernille
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.09.2018; Springer Nature B.V
• Subjects: Accumulation; Animals; Apoptosis; beta oxidation; biochemical pathways; Biochemistry; Biomedical and Life Sciences; Biomedicine; Cell Biology; Cytochromes; disease course; Exports; Fatty Acid Transport Proteins - metabolism; Fatty acids; Fatty Acids - metabolism; Fatty liver; Homeostasis; Humans; Hypoglycemic Agents - therapeutic use; Life Sciences; Lipid metabolism; Lipid Metabolism - physiology; Lipids; Lipogenesis; Liver; Liver - metabolism; Liver diseases; Metabolism; Mitochondria; Mitochondria - metabolism; Molecular chains; Molecular modelling; mortality; Non-alcoholic Fatty Liver Disease - drug therapy; Non-alcoholic Fatty Liver Disease - metabolism; Non-alcoholic Fatty Liver Disease - pathology; Normalizing; Organs; Oxidation; Oxidative stress; Peroxisomes; Plateaus; Reactive Oxygen Species - metabolism; Review; Steatosis; uptake mechanisms; Pharmacotherapy; Animal models; Lipid metabolism

Non-alcoholic fatty liver disease (NAFLD) is currently the world’s most common liver disease, estimated to affect up to one-fourth of the population. Hallmarked by hepatic steatosis, NAFLD is associated with a multitude of detrimental effects and increased mortality. This narrative review investigat...