FZD1/KLF10-hsa-miR-4762-5p/miR-224-3p-circular RNAs axis as prognostic biomarkers and therapeutic targets for glioblastoma: a comprehensive report

• Published in: BMC medical genomics Vol. 16; no. 1; p. 21
• Main Authors: Jia, Fang, Zhang, Lixia, Jiang, Zhengye, Tan, Guowei, Wang, Zhanxiang
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 08.02.2023; BioMed Central; BMC
• Subjects: Analysis; Biological markers; Biological products; Biomarkers; Brain cancer; Brain research; Cancer therapies; Care and treatment; ceRNA network; Circular RNA; Datasets; DEGs; Development and progression; Drug development; Early Growth Response Transcription Factors; Frizzled Receptors - genetics; Gene expression; Gene Regulatory Networks; Genes; Genomes; Genomics; Glioblastoma; Glioblastoma - genetics; Glioblastoma multiforme; Health aspects; Health savings accounts; Humans; Kruppel-Like Transcription Factors; Medical prognosis; Messenger RNA; MicroRNA; MicroRNAs; MicroRNAs - genetics; miRNA; Online data bases; Pathogenesis; Prognosis; Prognostic biomarker; RNA, Circular - genetics; RNA, Messenger - genetics; Signal transduction; Software; Statistical significance; Survival; Survival analysis; Therapeutic targets; Tumors; Wnt protein; China; DEGs; ceRNA network; Glioblastoma; Prognostic biomarker

The circular RNA (circRNA) plays a vital role in the pathogenesis of tumors as a competitive endogenous RNA (ceRNA). Given the high aggressiveness and fatality rate of glioblastoma (GBM) as well as poor prognosis, it is necessary to construct a circRNA-related ceRNA network for further studies on th...