Long noncoding RNA MALAT1 inhibits the apoptosis and autophagy of hepatocellular carcinoma cell by targeting the microRNA-146a/PI3K/Akt/mTOR axis

• Published in: Cancer cell international Vol. 20; no. 1; pp. 165 - 11
• Main Authors: Peng, Ningfu, He, Jingrong, Li, Jindu, Huang, Hao, Huang, Weiqiao, Liao, Yingyang, Zhu, Shaoliang
• Format: Journal Article
• Language: English
• Published: England BioMed Central 13.05.2020; BMC
• Subjects: 1-Phosphatidylinositol 3-kinase; Adenocarcinoma; AKT protein; Apoptosis; Autophagy; Cancer therapies; Cell cycle; Cell proliferation; Cell viability; Flow cytometry; HCC; Hepatocellular carcinoma; Kinases; Liver cancer; lncRNA; Lung cancer; Medical prognosis; Metastases; Metastasis; MicroRNAs; miR; miRNA; Neoplasia; Phagocytosis; PI3K; Polymerase chain reaction; Primary Research; Proteins; TOR protein; Transcription; Transfection; Western blotting; China; HCC; lncRNA; PI3K; Autophagy; miR; Apoptosis

Increased long noncoding RNA (lncRNA) expression is characteristic to hepatocellular carcinoma (HCC) and several other neoplasms. The present study aimed to identify the mechanism underlying modulation of HCC development by the lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1)....