Relative abundance of the Prevotella genus within the human gut microbiota of elderly volunteers determines the inter-individual responses to dietary supplementation with wheat bran arabinoxylan-oligosaccharides

• Published in: BMC microbiology Vol. 20; no. 1; pp. 283 - 14
• Main Authors: Chung, Wing Sun Faith, Walker, Alan W., Bosscher, Douwina, Garcia-Campayo, Vicenta, Wagner, Josef, Parkhill, Julian, Duncan, Sylvia H., Flint, Harry J.
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 14.09.2020; BioMed Central; BMC
• Subjects: Abundance; Aged; Analysis; Bacteroides; Bifidobacteria; Bifidobacterium; Body mass index; Cholesterol; Clinical trials; Colon; Compliance; Composition; Dextrins; Diet; Dietary Fiber; Dietary Supplements; Diversity; Double-Blind Method; Energy sources; Fatty acids; Fatty Acids, Volatile - metabolism; Feces - chemistry; Feces - microbiology; Female; Females; Gastrointestinal Microbiome - drug effects; Gastrointestinal Microbiome - physiology; Gut microbiota; Humans; Intestinal microflora; Leukocyte L1 Antigen Complex - analysis; Lipids - blood; Male; Maltodextrin; Metabolites; Microbiota; Microbiota (Symbiotic organisms); Microorganisms; Middle Aged; Oligosaccharides; Oligosaccharides - chemistry; Oligosaccharides - pharmacology; Physiological aspects; Polysaccharides; Polysaccharides - pharmacology; Prebiotics; Prevotella; Prevotella - drug effects; Prevotella - physiology; Relative abundance; Saccharides; Species composition; Triglycerides; Volunteers; Wheat; Wheat bran; Wheatbran extract; Xylans; Gut microbiota; Bifidobacteria; Arabinoxylan oligosaccharides (AXOS); Diversity; Wheatbran extract; Propionate; Prevotella; Short chain fatty acids; Bacteroides; Butyrate

The human colon is colonised by a dense microbial community whose species composition and metabolism are linked to health and disease. The main energy sources for colonic bacteria are dietary polysaccharides and oligosaccharides. These play a major role in modulating gut microbial composition and me...