Feasibility of Image Registration and Intensity-Modulated Radiotherapy Planning With Hyperpolarized Helium-3 Magnetic Resonance Imaging for Non–Small-Cell Lung Cancer

• Published in: International journal of radiation oncology, biology, physics Vol. 68; no. 1; pp. 273 - 281
• Main Authors: Ireland, Rob H., Bragg, Chris M., McJury, Mark, Woodhouse, Neil, Fichele, Stan, van Beek, Edwin J.R., Wild, Jim M., Hatton, Matthew Q.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2007; Elsevier Science Inc
• Subjects: ACCURACY; Airway Obstruction - diagnosis; Airway Obstruction - etiology; Carcinoma, Non-Small-Cell Lung - diagnostic imaging; Carcinoma, Non-Small-Cell Lung - pathology; Carcinoma, Non-Small-Cell Lung - radiotherapy; CARCINOMAS; COMPUTERIZED TOMOGRAPHY; Dose Fractionation, Radiation; Feasibility Studies; Helium; HELIUM 3; Hematology, Oncology and Palliative Medicine; Humans; Hyperpolarized helium-3 MRI; Image registration; IMRT treatment planning; Isotopes; Lung Neoplasms - diagnostic imaging; Lung Neoplasms - pathology; Lung Neoplasms - radiotherapy; LUNGS; Magnetic Resonance Imaging - methods; Male; NMR IMAGING; Non–small-cell lung cancer; PATIENTS; Physics Contribution; PLANNING; RADIATION DOSES; Radiology; RADIOLOGY AND NUCLEAR MEDICINE; RADIOTHERAPY; Radiotherapy Planning, Computer-Assisted - methods; Radiotherapy, Intensity-Modulated - methods; Tomography, X-Ray Computed - methods; X RADIATION; IMRT treatment planning; Hyperpolarized helium-3 MRI; Image registration; Non–small-cell lung cancer
• ISSN: 0360-3016; 1879-355X
• DOI: 10.1016/j.ijrobp.2006.12.068

Purpose: To demonstrate the feasibility of registering hyperpolarized helium-3 magnetic resonance images (3He-MRI) to X-ray computed tomography (CT) for functionally weighted intensity-modulated radiotherapy (IMRT) planning. Methods and Materials: Six patients with non–small-cell lung cancer underwe...