Systematic identification of type I and type II interferon-induced antiviral factors

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 109; no. 11; pp. 4239 - 4244
• Main Authors: Liu, Su-Yang, Sanchez, David Jesse, Aliyari, Roghiyh, Lu, Sun, Cheng, Genhong
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 13.03.2012; National Acad Sciences
• Subjects: Animals; Antiviral activity; antiviral properties; Antiviral state; Antivirals; ATP-Binding Cassette Sub-Family B Member 2; ATP-Binding Cassette Transporters; ATP-Binding Cassette Transporters - metabolism; Biological Sciences; Bone Marrow Cells; Bone Marrow Cells - cytology; Bone morphogenetic protein 2; Cytokines; cytology; Deoxyribonucleic acid; DNA; DNA Viruses; DNA Viruses - drug effects; DNA Viruses - immunology; drug effects; Fibroblasts; Fibroblasts - drug effects; Fibroblasts - metabolism; Fibroblasts - virology; Flow Cytometry; Gene expression; Gene Expression Regulation; Gene Expression Regulation - drug effects; genes; Genetic screening; HEK293 Cells; Humans; Immediate-early proteins; immunology; Infection; Infections; Interferon; Interferon Type I; Interferon Type I - immunology; Interferon Type I - pharmacology; Interferon-gamma; Interferon-gamma - immunology; Interferon-gamma - pharmacology; Interferons; Macrophages; Macrophages - drug effects; Macrophages - metabolism; Macrophages - virology; metabolism; Mice; Mice, Inbred C57BL; pharmacology; Plaque assay; Proteins; Replication; Ribonucleic acid; RNA; RNA viruses; Vero cells; Vesicular stomatitis virus; Vesiculovirus; Vesiculovirus - drug effects; Vesiculovirus - immunology; virology; Viruses

Type I and type II interferons (IFNs) are cytokines that establish the cellular antiviral state through the induction of IFN-stimulated genes (ISGs). We sought to understand the basis of the antiviral activity induced by type I and II IFNs in relation to the functions of their ISGs. Based on gene ex...