Obesity alters the lung myeloid cell landscape to enhance breast cancer metastasis through IL5 and GM-CSF

• Published in: Nature cell biology Vol. 19; no. 8; pp. 974 - 987
• Main Authors: Quail, Daniela F., Olson, Oakley C., Bhardwaj, Priya, Walsh, Logan A., Akkari, Leila, Quick, Marsha L., Chen, I-Chun, Wendel, Nils, Ben-Chetrit, Nir, Walker, Jeanne, Holt, Peter R., Dannenberg, Andrew J., Joyce, Johanna A.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.08.2017; Nature Publishing Group
• Subjects: 13/1; 13/106; 13/31; 13/51; 14/1; 14/5; 14/63; 38/77; 59/5; 631/443/319/1642/393; 631/67; 631/67/322; 631/67/327; 64/60; 82; 82/79; Adiposity; Adoptive Transfer; Animal models; Animals; Body weight loss; Breast cancer; Breast Neoplasms - genetics; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Cancer; Cancer Research; Cell Biology; Cell Line, Tumor; Coculture Techniques; Complications and side effects; Development and progression; Developmental Biology; Diet, Fat-Restricted; Disease Models, Animal; Disease Progression; Female; Gene Expression Regulation, Neoplastic; Granulocyte colony-stimulating factor; Granulocyte-macrophage colony-stimulating factor; Granulocyte-Macrophage Colony-Stimulating Factor - blood; Granulocyte-Macrophage Colony-Stimulating Factor - metabolism; Health aspects; Homeostasis; Interleukin 5; Interleukin-5 - blood; Interleukin-5 - metabolism; Leukocytes (neutrophilic); Life Sciences; Lung - metabolism; Lung - pathology; Lung Neoplasms - genetics; Lung Neoplasms - metabolism; Lung Neoplasms - prevention & control; Lung Neoplasms - secondary; Lungs; Metastases; Metastasis; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, SCID; Mice, Transgenic; Microenvironments; Neutrophil Infiltration; Neutrophilia; Neutrophils - metabolism; Neutrophils - pathology; Neutrophils - transplantation; Obesity; Obesity - complications; Obesity - diet therapy; Obesity - metabolism; Obesity - pathology; Physiological aspects; Pneumonia - etiology; Pneumonia - metabolism; Pneumonia - pathology; Pneumonia - prevention & control; Serum levels; Signal Transduction; Stem Cells; Time Factors; Tumor Microenvironment; Tumors; Weight control; Weight Loss; Weight reduction; United States

Obesity is associated with chronic, low-grade inflammation, which can disrupt homeostasis within tissue microenvironments. Given the correlation between obesity and relative risk of death from cancer, we investigated whether obesity-associated inflammation promotes metastatic progression. We demonst...