Development of a chitosan‐modified PLGA nanoparticle vaccine for protection against Escherichia coli K1 caused meningitis in mice

• Published in: Journal of nanobiotechnology Vol. 19; no. 1; pp. 69 - 15
• Main Authors: Zhang, Jin, Sun, Hongwu, Gao, Chen, Wang, Ying, Cheng, Xin, Yang, Yun, Gou, Qiang, Lei, Langhuang, Chen, Yanping, Wang, Xingyong, Zou, Quanming, Gu, Jiang
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 05.03.2021; BioMed Central; BMC
• Subjects: Acids; Aluminum; Antigens; Bacteremia; Care and treatment; Chitin; Chitosan; E coli; Efficiency; Escherichia coli; Escherichia coli K1; Ethics; Freeze drying; Glycolic acid; Health aspects; Immunization; Immunogenicity; Industrial applications; Meningitis; Microscopy; Nanoparticles; Neonates; PLGA; Polylactide-co-glycolide; Proteins; Size distribution; Stability; Vaccine; Vaccines; China; Beijing China; Japan; Nanoparticles; Vaccine; PLGA; Chitosan; Escherichia coli K1

Escherichia coli K1 (E. coli K1) caused neonatal meningitis remains a problem, which rises the urgent need for an effective vaccine. Previously, we rationally designed and produced the recombinant protein OmpAVac (Vo), which elicited protective immunity against E. coli K1 infection. However, Vo has...