Mitomycin, 5-fluorouracil, leflunomide, and mycophenolic acid directly promote hepatitis B virus replication and expression in vitro

• Published in: Virology journal Vol. 17; no. 1; pp. 89 - 11
• Main Authors: Ruan, Jie, Sun, Shuo, Cheng, Xin, Han, Pengyu, Zhang, Yinge, Sun, Dianxing
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 01.07.2020; BioMed Central; BMC
• Subjects: 5-Fluorouracil; Analysis; Anthracyclines; Antigens; Antineoplastic Agents - pharmacology; Antiretroviral drugs; Antiviral agents; Autoimmune diseases; Capsids; Care and treatment; Cell growth; Chemotherapy; Cytotoxicity; Deoxyribonucleic acid; Dexamethasone; DNA; Drug dosages; Enzyme-linked immunosorbent assay; Epirubicin; Fluorouracil; Fluorouracil - pharmacology; Gel electrophoresis; Health aspects; Hep G2 Cells; Hepatitis B; Hepatitis B e antigen; Hepatitis B e Antigens - genetics; Hepatitis B virus; Hepatitis B virus - drug effects; Hepatitis B virus - physiology; Humans; Immunosuppression; Immunosuppressive agents; Immunosuppressive Agents - pharmacology; Immunotherapy; Infection; Infections; Lamivudine; Leflunomide; Leflunomide - pharmacology; Luciferase; Medical research; Mitomycin; Mitomycin - pharmacology; Mycophenolic acid; Mycophenolic Acid - pharmacology; Nucleoside analogs; Phenotypes; Reactivation of hepatitis B virus; Mitomycin; Reinfection - etiology; Reinfection - virology; Replication; Statistical analysis; Virus replication; Virus Replication - drug effects; China; 5-fluorouracil; Lamivudine; Mycophenolic acid; Leflunomide; Reactivation of hepatitis B virus; Mitomycin

Reactivation of hepatitis B virus is a common complication that occurs in patients with hepatitis B virus (HBV) infection who have received cytotoxic chemotherapy or immunosuppressive therapy. This clinical phenomenon not only occurs in overt HBV infection patients but also occurs in patients with r...