SiO2 and ZnO dopants in three-dimensionally printed tricalcium phosphate bone tissue engineering scaffolds enhance osteogenesis and angiogenesis in vivo

• Published in: Acta biomaterialia Vol. 9; no. 11; pp. 9137 - 9148
• Main Authors: Fielding, Gary, Bose, Susmita
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.11.2013
• Subjects: 3-D printing; Acid Phosphatase - metabolism; angiogenesis; animal models; Animals; Biocompatibility; Biomedical materials; Blood Vessels - drug effects; Blood Vessels - growth & development; Blood Vessels - ultrastructure; Bone and Bones - drug effects; Bone and Bones - physiology; bone formation; Bone tissue engineering; Bones; Calcium phosphate; Calcium Phosphates - pharmacology; collagen; Collagen Type I - metabolism; Dopants; femur; Implants, Experimental; Ions - urine; Isoenzymes - metabolism; Mice; Neovascularization, Physiologic - drug effects; osteocalcin; Osteocalcin - metabolism; Osteoclasts - drug effects; Osteoclasts - metabolism; Osteogenesis - drug effects; Printing; prostheses; Rats; Rats, Sprague-Dawley; Scaffold; Scaffolds; silica; silicon; Silicon Dioxide - pharmacology; Surgical implants; Tartrate-Resistant Acid Phosphatase; TCP (protocol); tissue engineering; Tissue Engineering - methods; Tissue Scaffolds - chemistry; tricalcium phosphate; zinc; Zinc oxide; Zinc Oxide - pharmacology; Dopants; Calcium phosphate; 3-D printing; Bone tissue engineering; Scaffold

Calcium phosphate (CaP) scaffolds with three-dimensionally-interconnected pores play an important role in mechanical interlocking and biological fixation in bone implant applications. CaPs alone, however, are only osteoconductive (able to guide bone growth). Much attention has been given to the inco...